Age-related spatial cognitive impairment is correlated with a decrease in ChAT in the cerebral cortex, hippocampus and forebrain of SAMP8 mice

Neuroscience Letters

Volumn 454, Issue 3, 2009, Pages 212-217

  Wang, Feng ^a   Chen, Hong ^a   Sun, Xiaojiang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Aging; Choline acetyltransferase (ChAT); Senescence accelerated mice (SAM)

Indexed keywords

CHOLINE ACETYLTRANSFERASE; MESSENGER RNA; PROTEIN; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN REGION; COGNITIVE DEFECT; CONTROL GROUP; CONTROLLED STUDY; FOREBRAIN; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LATENT PERIOD; LEARNING; MALE; MAZE TEST; MEMORY; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE ACCELERATED MOUSE; WESTERN BLOTTING;

AGING; ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; CHOLINE O-ACETYLTRANSFERASE; COGNITION DISORDERS; IMMUNOHISTOCHEMISTRY; MALE; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 63249090206     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.03.030     Document Type: Article

References (31)

1. Abel T., Nguyen P.V., Barad M., Deuel T.A., Kandel E.R., and Bourtchouladze R. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88 (1997) 615-626
2. Arriagada P.V., Growdon J.H., Hedley-Whyte E.T., and Hyman B.T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42 (1992) 631-639
3. Bartus R.T., and Emerich D.F. Cholinergic markers in Alzheimer disease. J. Am. Med. Assoc. 282 (1999) 2208-2209
4. Bartus R.T., Dean III R.L., Beer B., and Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217 (1982) 408-414
5. Bartus R.T., Dean R.L., Pontecorvo M.J., and Flicker C. The cholinergic hypothesis: a historical overview, current perspective, and future directions. Ann. N.Y. Acad. Sci. 444 (1985) 332-358
6. Butterfield D.A., and Poon H.F. The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease. Exp. Gerontol. 40 (2005) 774-783
7. Chen G.H., Wang Y.J., Wang X.M., and Zhou J.N. Accelerated senescence prone mouse-8 shows early onset of deficits in spatial learning and memory in the radial six-arm water maze. Physiol. Behav. 82 (2004) 883-890
8. Cheng H., Yu J., Jiang Z., Zhang X., Liu C., Peng Y., Chen F., Qu Y., Jia Y., Tian Q., Xiao C., Chu Q., Nie K., Kan B., Hu X., and Han J. Acupuncture improves cognitive deficits and regulates the brain cell proliferation of SAMP8 mice. Neurosci. Lett. 432 (2008) 111-116
9. Duyckaerts C., Potier M.C., and Delatour B. Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol. 115 (2008) 5-38
10. Flood J.F., and Morley J.E. Learning and memory in the SAMP8 mouse. Neurosci. Biobehav. Rev. 22 (1998) 1-20
11. Houser C.R., Crawford G.D., Salvaterra P.M., and Vaughn J.E. Immunocytochemical localization of choline acetyltransferase in rat cerebral cortex: a study of cholinergic neurons and synapses. J. Comp. Neurol. 234 (1985) 17-34
12. Ikegami S., Shumiya S., and Kawamura H. Age-related changes in radial-arm maze learning and basal forebrain cholinergic systems in senescence accelerated mice (SAM). Behav. Brain Res. 51 (1992) 15-22
13. Kabuto H., Yokoi I., Mori A., Murakami M., and Sawada S. Neurochemical changes related to ageing in the senescence-accelerated mouse brain and the effect of chronic administration of nimodipine. Mech. Ageing Dev. 80 (1995) 1-9
14. Ke Z.J., Bowen W.M., and Gibson G.E. Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochem. Int. 49 (2006) 548-556
15. Ke Z.J., DeGiorqio L.A., Volpe B.T., and Gibson G.E. Reversal of thiamine deficiency-induced neurodegeneration. J. Neuropathol. Exp. Neurol. 62 (2003) 195-207
16. Kimelberg H.K., and Norenberg M.D. Astrocytes. Sci. Am. 260 (1989) 66-72
17. Kitamura Y., Zhao X.H., Ohnuki T., and Nomura Y. Ligand-binding characteristics of [3H]QNB, [3H]prazosin, [3H]rauwolscine, [3H]TCP and [3H]nitrendipine to cerebral cortical and hippocampal membranes of senescence accelerated mouse. Neurosci. Lett. 106 (1989) 334-338
18. Markowska A.L., Spangler E.L., and Ingram D.K. Behavioral assessment of the senescence-accelerated mouse (SAM P8 and R1). Physiol. Behav. 64 (1998) 15-26
19. Morris P.G.M. Development of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11 (1984) 47-60
20. Morrison J.H., and Patrick R.H. Life and death of neurons in the aging brain. Science 278 (1997) 412-419
21. Mufson E.J., Counts S.E., Perez S.E., and Ginsberg S.D. Cholinergic system during the progression of Alzheimer's disease: therapeutic implications. Expert Rev. Neurother. 8 (2008) 1703-1718
22. Paxinos G., and Franklin K. The Mouse Brain in Stereotaxic Coordinates: Compact. second ed. (2003), Academic Press, New York, USA
23. Perry E.K., Curtis M., Dick D.J., Candy J.M., Atack J.R., Bloxham C.A., Blessed G., Fairbairn A., Tomlinson B.E., and Perry R.H. Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 48 (1985) 413-421
24. Pisani A., Bonsi P., Centonze D., Gubellini P., Bernardi G., and Calabresi P. Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors. Neuropharmacology 45 (2003) 45-56
25. Strong R., Reddy V., and Morley J.E. Cholinergic deficits in the septal-hippocampal pathway of the SAM-P/8 senescence accelerated mouse. Brain Res. 14 (2003) 150-156
26. Sutherland R.J., Kolb B., and Whishaw I.Q. Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat. Neurosci. Lett. 31 (1982) 271-276
27. Sutherland R.J., Whishaw I.Q., and Regehr J.C. Cholinergic receptor blockade impairs spatial localization by use of distal cues in the rat. J. Comp. Physiol. Psychol. 96 (1982) 563-573
28. Takeda T., Hosokawa M., and Higuchi K. Senescence-accelerated mouse (SAM): a novel murine model of senescence. Exp. Gerontol. 32 (1997) 105-109
29. Takeda T., Matsushita T., Kurozumi M., Takemura K., Higuchi K., and Hosokawa M. Pathobiology of the senescence-accelerated mouse (SAM). Exp. Gerontol. 32 (1997) 117-127
30. Wu Y., Zhang A.Q., and David T. Age related changes of various marks of astrocytes in senescence-accelerated mice hippocampus. Neurochem. Int. 46 (2005) 565-574
31. Yoshio O. Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol. Int. 49 (1999) 921-937