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Volumn 26, Issue 9, 2012, Pages 1125-1132

Measurement of quetiapine and four quetiapine metabolites in human plasma by LC-MS/MS

Author keywords

Concentrations in patient samples; LC MS MS assay; N desalkylquetiapine; Quetiapine; Quetiapine sulfoxide

Indexed keywords

PLASMA (HUMAN); POSITIVE IONS;

EID: 84864812335     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2672     Document Type: Article
Times cited : (27)

References (17)
  • 2
    • 79953170187 scopus 로고    scopus 로고
    • Pharmacokinetic variability of quetiapine and the active metabolite N-desalkylquetiapine in psychiatric patients
    • Bakken GV, Rudberg I, Molden E, Refsum H and Hermann M. Pharmacokinetic variability of quetiapine and the active metabolite N-desalkylquetiapine in psychiatric patients. Therapeutic Drug Monitoring 2011; 33: 222-226.
    • (2011) Therapeutic Drug Monitoring , vol.33 , pp. 222-226
    • Bakken, G.V.1    Rudberg, I.2    Molden, E.3    Refsum, H.4    Hermann, M.5
  • 3
    • 58149527838 scopus 로고    scopus 로고
    • Preliminary evaluation of monolithic column high-performance liquid chromatography with tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection for the determination of quetiapine in human body fluids
    • Bellomarino SA, Brown AJ, Conlan XA and Barnett NW. Preliminary evaluation of monolithic column high-performance liquid chromatography with tris(2, 2′-bipyridyl)ruthenium(II) chemiluminescence detection for the determination of quetiapine in human body fluids. Talanta 2008; 77: 1873-1876.
    • (2008) Talanta , vol.77 , pp. 1873-1876
    • Bellomarino, S.A.1    Brown, A.J.2    Conlan, X.A.3    Barnett, N.W.4
  • 4
    • 0032986050 scopus 로고    scopus 로고
    • The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds
    • Bonfiglio R, King RC, Olah TV and Merkle K. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Communications in Mass Spectrometry 1999; 13: 1175-1185.
    • (1999) Rapid Communications in Mass Spectrometry , vol.13 , pp. 1175-1185
    • Bonfiglio, R.1    King, R.C.2    Olah, T.V.3    Merkle, K.4
  • 5
    • 78650569849 scopus 로고    scopus 로고
    • Second-generation antipsychotics in major depressive disorder: update and clinical perspective
    • Chen J, Gao K and Kemp DE. Second-generation antipsychotics in major depressive disorder: update and clinical perspective. Current Opinion in Psychiatry 2011; 24: 10-17.
    • (2011) Current Opinion in Psychiatry , vol.24 , pp. 10-17
    • Chen, J.1    Gao, K.2    Kemp, D.E.3
  • 6
    • 0345620787 scopus 로고    scopus 로고
    • Analysis and pharmacokinetics of quetiapine and two metabolites in human plasma using reversed-phase HPLC with ultraviolet and electrochemical detection
    • Davis PC, Wong J and Gefvert O. Analysis and pharmacokinetics of quetiapine and two metabolites in human plasma using reversed-phase HPLC with ultraviolet and electrochemical detection. Journal of Pharmaceutical and Biomedical Analysis 1999; 20: 271-282.
    • (1999) Journal of Pharmaceutical and Biomedical Analysis , vol.20 , pp. 271-282
    • Davis, P.C.1    Wong, J.2    Gefvert, O.3
  • 7
    • 72749084338 scopus 로고    scopus 로고
    • Development and validation of an LC-MS/MS method for the determination of quetiapine and four related metabolites in human plasma
    • Davis PC, Bravo O, Gehrke M and Azumaya CT. Development and validation of an LC-MS/MS method for the determination of quetiapine and four related metabolites in human plasma. Journal of Pharmaceutical and Biomedical Analysis 2010; 51: 1113-1119.
    • (2010) Journal of Pharmaceutical and Biomedical Analysis , vol.51 , pp. 1113-1119
    • Davis, P.C.1    Bravo, O.2    Gehrke, M.3    Azumaya, C.T.4
  • 8
    • 17844379465 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of quetiapine: an atypical antipsychotic
    • DeVane CL and Nemeroff CB. Clinical pharmacokinetics of quetiapine: an atypical antipsychotic. Clinical Pharmacokinetics 2001; 40: 509-522.
    • (2001) Clinical Pharmacokinetics , vol.40 , pp. 509-522
    • DeVane, C.L.1    Nemeroff, C.B.2
  • 9
    • 85165493255 scopus 로고    scopus 로고
    • FDA/CDER. Guidance for Industry. Bioanalytical Method Validation, Available from: (accessed 18 July 2011).
    • FDA/CDER. Guidance for Industry. Bioanalytical Method Validation, 2001. Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070107.pdf (accessed 18 July 2011).
    • (2001)
  • 10
    • 4744340358 scopus 로고    scopus 로고
    • Quetiapine serum concentrations in psychiatric patients - the influence of comedication
    • Hasselstrom J and Linnet K. Quetiapine serum concentrations in psychiatric patients - the influence of comedication. Therapeutic Drug Monitoring 2004; 26: 486-491.
    • (2004) Therapeutic Drug Monitoring , vol.26 , pp. 486-491
    • Hasselstrom, J.1    Linnet, K.2
  • 11
    • 49549104014 scopus 로고    scopus 로고
    • N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1a agonist, as a putative mediator of quetiapine's antidepressant acitivty
    • Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB and Roth BL. N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1a agonist, as a putative mediator of quetiapine's antidepressant acitivty. Neuropsychopharmacology 2008; 33: 2303-2312.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2303-2312
    • Jensen, N.H.1    Rodriguiz, R.M.2    Caron, M.G.3    Wetsel, W.C.4    Rothman, R.B.5    Roth, B.L.6
  • 12
    • 0345763103 scopus 로고    scopus 로고
    • Simultaneous determination of quetiapine and three metabolites in human plasma by high-performance liquid chromatography-electrospray ionisation mass spectrometry
    • Li K, Cheng Z, Li X, Bai X, Zhang B, Wang F and Li H. Simultaneous determination of quetiapine and three metabolites in human plasma by high-performance liquid chromatography-electrospray ionisation mass spectrometry. Acta Pharmacologica Sinica 2004; 25: 110-114.
    • (2004) Acta Pharmacologica Sinica , vol.25 , pp. 110-114
    • Li, K.1    Cheng, Z.2    Li, X.3    Bai, X.4    Zhang, B.5    Wang, F.6    Li, H.7
  • 14
    • 77954121379 scopus 로고    scopus 로고
    • Relationship between dopamine D2 receptor occupancy, clinical response, and drug and monoamine metabolites levels in plasma and cerebrospinal fluid. A pilot study in patients suffering from first-episode schizophrenia treated with quetiapine
    • Nikisch G, Baumann P, Kießling B, Reinert M, Wiedemann G, Kehr J, Mathé AA, Piel M, Roesch F, Weisser H, Schneider P and Hertel A. Relationship between dopamine D2 receptor occupancy, clinical response, and drug and monoamine metabolites levels in plasma and cerebrospinal fluid. A pilot study in patients suffering from first-episode schizophrenia treated with quetiapine. Journal of Psychiatric Research 2010; 44: 759-759.
    • (2010) Journal of Psychiatric Research , vol.44 , pp. 759-759
    • Nikisch, G.1    Baumann, P.2    Kießling, B.3    Reinert, M.4    Wiedemann, G.5    Kehr, J.6    Mathé, A.A.7    Piel, M.8    Roesch, F.9    Weisser, H.10    Schneider, P.11    Hertel, A.12
  • 15
    • 33845988396 scopus 로고    scopus 로고
    • Metabolic drug interactions with newer antipsychotics: a comparative review
    • Spina E and de Leon J. Metabolic drug interactions with newer antipsychotics: a comparative review. Basic and Clinical Pharmacology and Toxicology 2007; 100: 4-22.
    • (2007) Basic and Clinical Pharmacology and Toxicology , vol.100 , pp. 4-22
    • Spina, E.1    de Leon, J.2
  • 16
    • 53549133095 scopus 로고    scopus 로고
    • UPLC-MS-MS analysis of quetiapine and its two active metabolites, 7-hydroxyquetiapine and 7-hydroxy-n-dealkylquetiapine, in rat plasma and cerebrospinal fluid
    • Tu J-Y, Xu P, Xu D-H and Li H-D. UPLC-MS-MS analysis of quetiapine and its two active metabolites, 7-hydroxyquetiapine and 7-hydroxy-n-dealkylquetiapine, in rat plasma and cerebrospinal fluid. Chromatographia 2008; 6: 525-532.
    • (2008) Chromatographia , vol.6 , pp. 525-532
    • Tu, J.-Y.1    Xu, P.2    Xu, D.-H.3    Li, H.-D.4
  • 17
    • 39749195403 scopus 로고    scopus 로고
    • Steady-state pharmacokinetic, safety, and tolerability profiles of quetiapine, norquetiapine, and other quetiapine metabolites in pediatric and adult patients with psychotic disorders
    • Winter HR, Earley WR, Hamer-Maansson JE, Davis PC and Smith MA. Steady-state pharmacokinetic, safety, and tolerability profiles of quetiapine, norquetiapine, and other quetiapine metabolites in pediatric and adult patients with psychotic disorders. Journal of Child and Adolescent Psychopharmacology 2008; 18: 81-98.
    • (2008) Journal of Child and Adolescent Psychopharmacology , vol.18 , pp. 81-98
    • Winter, H.R.1    Earley, W.R.2    Hamer-Maansson, J.E.3    Davis, P.C.4    Smith, M.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.