Analysis and pharmacokinetics of quetiapine and two metabolites in human plasma using reversed-phase HPLC with ultraviolet and electrochemical detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 20, Issue 1-2, 1999, Pages 271-282

  Davis, Patricia C ^a   Wong, James ^a   Gefvert, O ^b  

^a ASTRAZENECA   (United Kingdom)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Antipsychotics; HPLC; Metabolites; Plasma; Positron emission tomography; Quetiapine

Indexed keywords

DRUG METABOLITE; QUETIAPINE;

AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG HYDROXYLATION; DRUG METABOLISM; ELECTROCHEMICAL DETECTION; HUMAN; LIQUID LIQUID EXTRACTION; MALE; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCHIZOPHRENIA;

ADULT; ANTIPSYCHOTIC AGENTS; BIOTRANSFORMATION; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIBENZOTHIAZEPINES; ELECTROCHEMISTRY; HUMANS; INDICATORS AND REAGENTS; MALE; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SOLUTIONS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0345620787     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(99)00036-9     Document Type: Article

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