The highs and lows of amygdala reactivity in bipolar disorders

American Journal of Psychiatry

Volumn 169, Issue 8, 2012, Pages 780-783

  Hariri, Ahmad R ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYGDALOID NUCLEUS; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; BRAIN FUNCTION; COGNITION; EDITORIAL; EMOTION; HUMAN; MANIA; MOOD; NEUROPATHOLOGY; ORBITAL CORTEX; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL;

EID: 84864808086     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2012.12050639     Document Type: Editorial

References (13)

1. Vizueta N, Rudie JD, Townsend JD, Torrisi S, Moody TD, Bookheimer SY, Altshuler LL: Regional fMRI hypoactivation and altered functional connectivity during emotion processing in nonmedicated depressed patients with bipolar II disorder. Am J Psychiatry 2012; 169:831-840
2. Altshuler L, Bookheimer S, Proenza MA, Townsend J, Sabb F, Firestine A, Bartzokis G, Mintz J, Mazziotta J, Cohen MS: Increased amygdala activation during mania: a functional magnetic resonance imaging study. Am J Psychiatry 2005; 162:1211-1213 (Pubitemid 40770709)
3. Hariri AR, Whalen PJ: The amygdala: inside and out. F1000 Biol Rep 2011; 3:2
4. Altshuler L, Bookheimer S, Townsend J, Proenza MA, Sabb F, Mintz J, Cohen MS: Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study. Bipolar Disord 2008; 10:708-717
5. Foland-Ross LC, Bookheimer SY, Lieberman MD, Sugar CA, Townsend JD, Fischer J, Torrisi S, Penfold C, Madsen SK, Thompson PM, Altshuler LL: Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia. Neuroimage 2012; 59:738-744
6. Hariri AR, Bookheimer SY, Mazziotta JC: Modulating emotional responses: effects of a neocortical network on the limbic system. Neuroreport 2000; 11:43-48 (Pubitemid 30053387)
7. Ochsner KN, Bunge SA, Gross JJ, Gabrieli JD: Rethinking feelings: an fMRI study of the cognitive regulation of emotion. J Cogn Neurosci 2002; 14:1215-1229 (Pubitemid 35305826)
8. Hariri AR, Mattay VS, Tessitore A, Fera F, Weinberger DR: Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry 2003; 53:494-501 (Pubitemid 36331888)
9. Kim MJ, Loucks RA, Palmer AL, Brown AC, Solomon KM, Marchante AN, Whalen PJ: The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety. Behav Brain Res 2011; 223:403-410
10. Foland LC, Altshuler LL, Bookheimer SY, Eisenberger N, Townsend J, Thompson PM: Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry Res 2008; 162:27-37 (Pubitemid 50008260)
11. Versace A, Thompson WK, Zhou D, Almeida JR, Hassel S, Klein CR, Kupfer DJ, Phillips ML: Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder. Biol Psychiatry 2010; 67:422-431
12. Chen CH, Suckling J, Lennox BR, Ooi C, Bullmore ET: A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord 2011; 13:1-15
13. Cerullo MA, Fleck DE, Eliassen JC, Smith MS, DelBello MP, Adler CM, Strakowski SM: A longitudinal functional connectivity analysis of the amygdala in bipolar I disorder across mood states. Bipolar Disord 2012; 14:175-184