Severe reaction following sugammadex injection: Hypersensitivity?

Journal of Investigational Allergology and Clinical Immunology

Volumn 22, Issue 5, 2012, Pages 382-

  Soria, A ^a   Motamed, C ^b   Gaouar, H ^a   Chemam, S ^b   Amsler, E ^a   Frances C ^a  

^a HÔPITAL TENON   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Cyclodextrins; Hypersensitivity; Sugammadex

Indexed keywords

ADRENALIN; AMOXICILLIN PLUS CLAVULANIC ACID; HISTAMINE; LATEX; PROPOFOL; REMIFENTANIL; ROCURONIUM; SUGAMMADEX;

ADULT; ANTIBIOTIC PROPHYLAXIS; ARTICLE; ARTIFICIAL VENTILATION; CASE REPORT; CONTROLLED STUDY; DISEASE SEVERITY; DRUG HYPERSENSITIVITY; DRUG RECHALLENGE; ENDOTRACHEAL INTUBATION; ERYTHEMA; HISTAMINE BLOOD LEVEL; HUMAN; HYPOTENSION; INTENSIVE CARE; INTRACUTANEOUS TEST; LARYNGOSCOPY; MALE; OXYGEN SATURATION; PRICK TEST; SEDATION; TACHYCARDIA;

DRUG HYPERSENSITIVITY; GAMMA-CYCLODEXTRINS; HUMANS; INJECTIONS; MALE; MIDDLE AGED;

EID: 84864806949     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Yang LP, Keam SJ. Sugammadex: a review of its use in anaesthetic practice. Drugs. 2009;69:919-42.
2. Menéndez-Ozcoidi L, Ortiz-Gómez JR, Olaguibel-Ribero JM, Salvador-Bravo MJ. Allergy to low dose sugammadex. Anaesthesia. 2011;66:217-9.
3. Peeters PA, van den Heuvel MW, van Heumen E, Passier PC, Smeets JM, van Iersel T, Zwiers A. Safety, tolerability and pharmacokinetics of sugammadex using single high doses (up to 96 mg/kg) in healthy adult subjects: a randomized, doubleblind, crossover, placebo-controlled, single-centre study. Clin Drug Investig. 2010;30:867-74.
4. FDA Anesthetic and Life Support Advisory Committee Meeting Sugammadex Sodium Injection (NDA 22-225) March 11, 2008 (online: avaible from URL: http://www.fda.gov/ohrms/dockets/ ac/08/briefinf/2008-4346b1-02-Orgaron.pdf).