Alpha B-crystallin improved survival of retinal ganglion cells in a rat model of acute ocular hypertension

Neural Regeneration Research

Volumn 7, Issue 19, 2012, Pages 1493-1497

  Wu, Zhihong ^a   Wang, Layi ^b   Hou, Shike ^a  

^a GENERAL HOSPITAL OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^b Ningbo Eye Hospital   (China)

Author keywords

Acute ocular hypertension; Caspase 3; Neural regeneration; Retinal ganglion cells; B crystallin protein

Indexed keywords

ALPHA CRYSTALLIN; CASPASE 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; IMMUNOFLUORESCENCE TEST; INTRAOCULAR HYPERTENSION; MALE; NONHUMAN; PROTEIN EXPRESSION; PUNCTURE; RAT; RETINA GANGLION CELL;

EID: 84864795296     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2012.19.008     Document Type: Article

References (17)

1. Kim JY, Sohn HJ, Lee EY, et al. Expression of αβ-crystallin in the peripapillary glial cells of the developing chick retina. Neurochem Res. 2011;36(1):76-82.
2. Tang G, Perng MD, Wilk S, et al. Oligomers of mutant glial fibrillary acidic protein (GFAP) inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition. J Biol Chem. 2010;285(14):10527-10537.
3. Gabert BJ, Kültz D. Osmoprotective proteome adjustments in mouse kidney papilla. Biochim Biophys Acta. 2011;1814(3):435-448.
4. Stegh AH, Kesari S, Mahoney JE, et al. Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Proc Natl Acad Sci U S A. 2008;105(31):10703-10708.
5. Ousman SS, Tomooka BH, van Noort JM, et al. Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature. 2007;448(7152):474-479.
6. Goplen D, Bougnaud S, Rajcevic U, et al. αβ-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells. Am J Pathol. 2010;177(4):1618-1628.
7. Golenhofen N, Arbeiter A, Koob R, et al. Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin. J Mol Cell Cardiol. 2002; 34(3):309-319.
8. Wang X, Klevitsky R, Huang W, et al. AlphaB-crystallin modulates protein aggregation of abnormal desmin. Circ Res. 2003;93(10):998-1005.
9. Verschuure P, Croes Y, van den Jssel PR, et al. Translocation of small heat shock proteins to the actin cytoskeleton upon proteasomal inhibition. J Mol Cell Cardiol. 2002;34(2):117-128.
10. Zhang L. Effects of α-crystallin on axonal regeneration and survival of rats retinal ganglion cells in vivo following optic nerve injury. Chongqing: Third Military Medical University. 2007.
11. Rosenbaum DM, Rosenbaum PS, Gupta A, et al. Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. Vision Res. 1997;37(24): 3445-3451.
12. Kamradt MC, Chen F, Sam S, et al. The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation. J Biol Chem. 2002;277(41):38731-38736.
13. The Ministry of Science and Technology of the People's Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006-09-30.
14. Niu Y, Zhang R, Zhou Z, et al. An experimental study of therapeutic effect of basic fibroblast growth factor on experimental retinal ischemia/reperfusion injury. Zhonghua Yan Ke Za Zhi. 2002;38(9):530-534.
15. Liu ZM, Ren X, Wang Y, et al. Protective effects of mixed crystamn on injured retinal ganglion cells after optic nerve injury in Long-Evans rats. Zhonghua Chuangshang Zazhi. 2006;22(12):926-929.
16. nd ed. San Dieago: Academic Press. 1986: 54-56.
17. Duan XC, Qing GP, Li C. Quatitative analysis of retinal ganglion cells in animals. Guoji Yanke Zazhi. 2006;6(3): 667-670.