Adipogenesis of the mesenchymal stromal cells and bone oedema in rheumatoid arthritis

Clinical and Experimental Rheumatology

Volumn 30, Issue 3, 2012, Pages 332-337

  Okada, A ^a   Yamasaki, S ^a   Koga, T ^a   Kawashiri, S ^a   Tamai, M ^a   Origuchi, T ^b   Nakamura, H ^a   Eguchi, K ^a   Kawakami, A ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

Smooth muscle actin; Adipogenesis; F actin; Fatty acid binding proteins 4; Lipoprotein lipase; Mesenchymal stem cells; Ppar ; Rheumatoid arthritis

Indexed keywords

F ACTIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PHALLOIDIN; SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADIPOGENESIS; ARTICLE; BONE DISEASE; BONE EDEMA; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EDEMA; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STROMA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS;

ADIPOCYTES; ADIPOGENESIS; ARTHRITIS, RHEUMATOID; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; DISEASE PROGRESSION; EDEMA; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MAGNETIC RESONANCE IMAGING; MESENCHYMAL STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864769968     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. SCHETT G. Bone marrow edema. Ann N Y Acad Sci 2009; 1154: 35-40.
2. MCQUEEN FM, STEWART N, CRABBE J et al. Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement. Ann Rheum Dis 1999; 58: 156-63.
3. DALBETH N, SMITH T, GRAY S et al. Cellular characterization of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease. Ann Rheum Dis 2009; 68: 279-82.
4. BØYESEN P, HAAVARDSHOLM EA, OSTERGAARD M, VAN DER HEIJDE D, SESSENG S, KVIEN TK. MRI in early rheumatoid arthri-tis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression. Ann Rheum Dis 2011; 70: 428-33.
5. HETLAND ML, STENGAARD-PEDERSEN K, JUNKER P et al. CIMESTRA study group. Radiographic progression and remission rates in early rheumatoid arthritis - MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial. Ann Rheum Dis 2010; 69: 1789-95.
6. PITTENGER MF, MACKAY AM, BECK SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-7.
7. CAPLAN AI. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-50.
8. SALEM HK, THIEMERMANN C: Mesenchymal stromal cells: current understanding and clinical status. Stem Cells 2010; 28: 585-96.
9. DJOUAD F, BOUFFI C, GHANNAM S, NOËL D, JORGENSEN C. Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases. Nat Rev Rheumatol 2009; 5: 392-9.
10. TOMITA T, KASHIWAGI N, SHIMAOKA Y et al. Phenotypic characteristics of bone marrow cells in patients with rheumatoid arthritis. J Rheumatol 1994; 21: 1608-14.
11. DE BARI C, DELL'ACCIO F, TYLZANOWSKI P, LUYTEN FP. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum 2001; 44: 1928-42.
12. YAMASAKI S, NAKASHIMA T, KAWAKAMI A et al. Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cells. Rheumatology (Oxford) 2004; 43: 448-52.
13. AIDINIS V, PLOWS D, HARALAMBOUS S et al. Functional analysis of an arthritogenic synovial fibroblast. Arthritis Res Ther 2003; 5: R140-R57.
14. MATTEY DL, DAWES PT, NIXON NB, SLATER H. Transforming growth factor beta 1 and interleukin 4 induced alpha smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor. Ann Rheum Dis 1997; 56: 426-31.
15. GUSTAFSON B, SMITH U. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 2006; 281: 9507-16.