Pulmonary intravascular macrophages as proinflammatory cells in heaves, an asthma-like equine disease

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 303, Issue 3, 2012, Pages

  Aharonson Raz, Karin ^a   Lohmann, Katharina L ^a   Townsend, Hugh G ^a   Marques, Fernando ^a   Singh, Baljit ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Endotoxin; Gadolinium chloride; Horse; Lung inflammation; Recurrent airway obstruction

Indexed keywords

ENDOTOXIN; GADOLINIUM CHLORIDE; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; TOLL LIKE RECEPTOR 4;

ALFALFA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; DUST; HEAVES; HORSE DISEASE; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MARE; MOULD; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY INTRAVASCULAR MACROPHAGE; RESPIRATORY TRACT ALLERGY; SCORING SYSTEM; WHEEZING;

AIRWAY OBSTRUCTION; ANIMALS; ASTHMA; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE; DUST; ENDOTOXINS; FEMALE; HORSE DISEASES; HORSES; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; NEUTROPHILS; PNEUMONIA; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84864766255     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00271.2011     Document Type: Article

References (57)

1. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 406: 782-787, 2000.
2. Aharonson-Raz K, Singh B. Pulmonary intravascular macrophages and endotoxin-induced pulmonary pathophysiology in horses. Can J Vet Res 74: 45-49, 2010.
3. Ainsworth DM, Wagner B, Franchini M, Grunig G, Erb HN, Tan JY. Time-dependent alterations in gene expression of interleukin-8 in the bronchial epithelium of horses with recurrent airway obstruction. Am J Vet Res 67: 669-677, 2006.
4. Atwal OS, Saldanha KA. Erythrophagocytosis in alveolar capillaries of goat lung: ultrastructural properties of blood monocytes. Acta Anat (Basel) 124: 245-254, 1985.
5. Bannenberg G, Lundborg M, Johansson A. Pulmonary macrophage function in systemic gadolinium chloride-pretreated rats. Toxicol Lett 80: 105-107, 1995.
6. Berndt A, Derksen FJ, Venta PJ, Ewart S, Yuzbasiyan-Gurkan V, Robinson NE. Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction. Am J Physiol Lung Cell Mol Physiol 292: L936-L943, 2007.
7. Brain JD, Molina RM, DeCamp MM, Warner AE. Pulmonary intra-vascular macrophages: their contribution to the mononuclear phagocyte system in 13 species. Am J Physiol Lung Cell Mol Physiol 276: L146-L154, 1999.
8. Brazil TJ. The role of neutrophils in equine heaves. In: Proceedings of the Second World Equine Airways Symposium, edited by Viel L, Robinson NE, Ducharme NG, and McGorum BC. Edinburgh, UK, 2001, p. 1-12.
9. Charavaryamath C, Janardhan KS, Caldwell S, Singh B. Pulmonary intravascular monocytes/macrophages in a rat model of sepsis. Anat Rec A Discov Mol Cell Evol Biol 288: 1259-1271, 2006.
10. Charavaryamath C, Janardhan KS, Townsend HG, Willson P, Singh B. Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness. Respir Res 6: 50, 2005.
11. Couetil LL, Rosenthal FS, DeNicola DB, Chilcoat CD. Clinical signs, evaluation of bronchoalveolar lavage fluid, and assessment of pulmonary function in horses with inflammatory respiratory disease. Am J Vet Res 62: 538-546, 2001.
12. Couetil LL, Ward MP. Analysis of risk factors for recurrent airway obstruction in North American horses: 1,444 cases (1990-1999). J Am Vet Med Assoc 223: 1645-1650, 2003.
13. Courouce-Malblanc A, Fortier G, Pronost S, Siliart B, Brachet G. Comparison of prednisolone and dexamethasone effects in the presence of environmental control in heaves-affected horses. Vet J 175: 227-233, 2008.
14. Davis E, Rush BR. Equine recurrent airway obstruction: pathogenesis, diagnosis, and patient management. Vet Clin North Am Equine Pract 18: 453-467, 2002.
15. DeCamp MM, Warner AE, Molina RM, Brain JD. Hepatic versus pulmonary uptake of particles injected into the portal circulation in sheep. Endotoxin escapes hepatic clearance causing pulmonary inflammation. Am Rev Respir Dis 146: 224-231, 1992.
16. Facci MR, Auray G, Meurens F, Buchanan R, van Kessel J, Gerdts V. Stability of expression of reference genes in porcine peripheral blood mono-nuclear and dendritic cells. Vet Immunol Immunopathol 141: 11-15, 2011.
17. Franchini M, Gilli U, Akens MK, Fellenberg RV, Bracher V. The role of neutrophil chemotactic cytokines in the pathogenesis of equine chronic obstructive pulmonary disease (COPD). Vet Immunol Immunopathol 66: 53-65, 1998.
18. Gaca JG, Palestrant D, Lukes DJ, Olausson M, Parker W, Davis RD Jr. Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate. J Surg Res 112: 19-25, 2003.
19. Gill SS, Suri SS, Janardhan KS, Caldwell S, Duke T, Singh B. Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model. Respir Res 9: 69, 2008.
20. Herszberg B, Ramos-Barbon D, Tamaoka M, Martin JG, Lavoie JP. Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling. J Allergy Clin Immunol 118: 382-388, 2006.
21. Joubert P, Cordeau ME, Lavoie JP. Cytokine mRNA expression of pulmonary macrophages varies with challenge but not with disease state in horses with heaves or in controls. Vet Immunol Immunopathol 142: 236-242, 2011.
22. Kirychuk S, Senthilselvan A, Dosman JA, Zhou C, Barber EM, Rhodes CS, Hurst TS. Predictors of longitudinal changes in pulmonary function among swine confinement workers. Can Respir J 5: 472-478, 1998.
23. Klingensmith WC, Lovett VJ Jr. Lung uptake of 99mTc-sulfur colloid secondary to intraperitoneal endotoxin. J Nucl Med 15: 1028-1031, 1974.
24. Kuebler WM, Parthasarathi K, Wang PM, Bhattacharya J. A novel signaling mechanism between gas and blood compartments of the lung. J Clin Invest 105: 905-913, 2000.
25. Longworth KE. The comparative biology of pulmonary intravascular macrophages. Front Biosci 2: d232-d241, 1997.
26. Marinkovic D, Aleksic-Kovacevic S, Plamenac P. Cellular basis of chronic obstructive pulmonary disease in horses. Int Rev Cytol 257: 213-247, 2007.
27. McGorum BC, Dixon PM, Halliwell RE. Phenotypic analysis of peripheral blood and bronchoalveolar lavage fluid lymphocytes in control and chronic obstructive pulmonary disease affected horses, before and after 'natural (hay and straw) challenges.' Vet Immunol Immunopathol 36: 207-222, 1993.
28. McGorum BC, Ellison J, Cullen RT. Total and respirable airborne dust endotoxin concentrations in three equine management systems. Equine Vet J 30: 430-434, 1998.
29. Michel O, Ginanni R, Duchateau J, Vertongen F, Le Bon B, Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 21: 441-448, 1991.
30. Mizgerd JP, Molina RM, Stearns RC, Brain JD, Warner AE. Gadolinium induces macrophage apoptosis. J Leukoc Biol 59: 189-195, 1996.
31. Naylor JM, Clark EG, Clayton HM. Chronic obstructive pulmonary disease: usefulness of clinical signs, bronchoalveolar lavage, and lung biopsy as diagnostic and prognostic aids. Can Vet J 33: 591-598, 1992.
32. Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, Nakanishi K, Kimoto M, Miyake K, Takeda K, Akira S. Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 164: 3476-3479, 2000.
33. Parbhakar OP, Duke T, Townsend HG, Singh B. Depletion of pulmonary intravascular macrophages partially inhibits lipopolysaccharide-in-duced lung inflammation in horses. Vet Res 36: 557-569, 2005.
34. Parbhakar OP, Duke T, Townsend HG, Singh B. Immunophenotypic characterization and depletion of pulmonary intravascular macrophages of horses. Vet Res 35: 39-51, 2004.
35. Piehler AP, Grimholt RM, Ovstebo R, Berg JP. Gene expression results in lipopolysaccharide-stimulated monocytes depend significantly on the choice of reference genes. BMC Immunol 11: 21, 2010.
36. Pirie RS, Collie DD, Dixon PM, McGorum BC. Inhaled endotoxin and organic dust particulates have synergistic proinflammatory effects in equine heaves (organic dust-induced asthma). Clin Exp Allergy 33: 676-683, 2003.
37. Pirie RS, Dixon PM, Collie DD, McGorum BC. Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses. Equine Vet J 33: 311-318, 2001.
38. Pirie RS, Dixon PM, McGorum BC. Endotoxin contamination contributes to the pulmonary inflammatory and functional response to Aspergillus fumigatus extract inhalation in heaves horses. Clin Exp Allergy 33: 1289-1296, 2003.
39. Rizzo MC, Naspitz CK, Fernandez-Caldas E, Lockey RF, Mimica I, Sole D. Endotoxin exposure and symptoms in asthmatic children. Pediatr Allergy Immunol 8: 121-126, 1997.
40. Robinson NE. International Workshop on Equine Chronic Airway Disease. Michigan State University 16-18 June 2000. Equine Vet J 33: 5-19, 2001.
41. Robinson NE, Berney C, Eberhart S, deFeijter-Rupp HL, Jefcoat AM, Cornelisse CJ, Gerber VM, Derksen FJ. Coughing, mucus accumulation, airway obstruction, and airway inflammation in control horses and horses affected with recurrent airway obstruction. Am J Vet Res 64: 550-557, 2003.
42. Rush BR, Flaminio MJ, Matson CJ, Hakala JE, Shuman W. Cytologic evaluation of bronchoalveolar lavage fluid from horses with recurrent airway obstruction after aerosol and parenteral administration of beclo-methasone dipropionate and dexamethasone, respectively. Am J Vet Res 59: 1033-1038, 1998.
43. Rush BR, Raub ES, Rhoads WS, Flaminio MJ, Matson CJ, Hakala JE, Gillespie JR. Pulmonary function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 59: 1039-1043, 1998.
44. Schneberger D, Aharonson-Raz K, Singh B. Pulmonary intravascular macrophages and lung health: What are we missing? Am J Physiol Lung Cell Mol Physiol 302: L498-L503, 2012.
45. Schneberger D, Caldwell S, Suri SS, Singh B. Expression of toll-like receptor 9 in horse lungs. Anat Rec (Hoboken) 292: 1068-1077, 2009.
46. Simonen-Jokinen T, Pirie RS, McGorum BC, Maisi P. Effect of composition and different fractions of hay dust suspension on inflammation in lungs of heaves-affected horses: MMP-9 and MMP-2 as indicators of tissue destruction. Equine Vet J 37: 412-417, 2005.
47. Singh B, da la Concha-Bermejillo A. Gadolinium chloride removes pulmonary intravascular macrophages and curtails the degree of ovine lenti-virus-induced lymphoid interstitial pneumonia. Int J Exp Pathol 79: 151-162, 1998.
48. Singh B, Pearce JW, Gamage LN, Janardhan K, Caldwell S. Depletion of pulmonary intravascular macrophages inhibits acute lung inflammation. Am J Physiol Lung Cell Mol Physiol 286: L363-L372, 2004.
49. Singh Suri S, Janardhan KS, Parbhakar O, Caldwell S, Appleyard G, Singh B. Expression of toll-like receptor 4 and 2 in horse lungs. Vet Res 37: 541-551, 2006.
50. Smid T, Heederik D, Houba R, Quanjer PH. Dust-and endotoxin-related acute lung function changes and work-related symptoms in workers in the animal feed industry. Am J Ind Med 25: 877-888, 1994.
51. Staub NC. Pulmonary intravascular macrophages. Annu Rev Physiol 56: 47-67, 1994.
52. Staub NC Sr, Longworth KE, Serikov V, Jerome EH, Elsasser T. Detergent inhibits 70-90% of responses to intravenous endotoxin in awake sheep. J Appl Physiol 90: 1788-1797, 2001.
53. Thenappan T, Goel A, Marsboom G, Fang YH, Toth PT, Zhang HJ, Kajimoto H, Hong Z, Paul J, Wietholt C, Pogoriler J, Piao L, Rehman J, Archer SL. A central role for CD68(+) macrophages in hepatopulmo-nary syndrome. Reversal by macrophage depletion. Am J Respir Crit Care Med 183: 1080-1091, 2011.
54. Thenappan T, Goel A, Marsboom G, Fang YH, Toth PT, Zhang HJ, Kajimoto H, Hong Z, Paul J, Wietholt C, Pogoriler J, Piao L, Rehman J, Archer SL. A central role for CD68(+) macrophages in hepatopulmo-nary syndrome: reversal by macrophage depletion. Am J Respir Crit Care Med 183: 1080-1091, 2011.
55. Vogelzang PF, van der Gulden JW, Folgering H, Kolk JJ, Heederik D, Preller L, Tielen MJ, van Schayck CP. Endotoxin exposure as a major determinant of lung function decline in pig farmers. Am J Respir Crit Care Med 157: 15-18, 1998.
56. Warner AE. Pulmonary intravascular macrophages. Role in acute lung injury. Clin Chest Med 17: 125-135, 1996.
57. Whiteley LO, Maheswaran SK, Weiss DJ, Ames TR. Immunohisto-chemical localization of Pasteurella haemolytica A1-derived endotoxin, leukotoxin, and capsular polysaccharide in experimental bovine Pasteurella pneumonia. Vet Pathol 27: 150-161, 1990.