Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation

Journal of the American College of Cardiology

Volumn 60, Issue 6, 2012, Pages 539-545

  Parvez, Babar ^a   Vaglio, Joseph ^a   Rowan, Shane ^a   Muhammad, Raafia ^a   Kucera, Gayle ^a   Stubblefield, Tanya ^a   Carter, Shannon ^a   Roden, Dan ^a   Darbar, Dawood ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antiarrhythmics; atrial fibrillation; genomics; polymorphisms

Indexed keywords

ANTIARRHYTHMIC AGENT;

ADULT; AGED; ALLELE; ARTICLE; CAUCASIAN; CHROMOSOME 4Q; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG RESPONSE; ELECTROCARDIOGRAM; FEMALE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEART ATRIUM FIBRILLATION; HOLTER MONITORING; HUMAN; KCNN3 GENE; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT DISEASE; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; ZINC FINGER HOMEOBOX 3 GENE;

AGED; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; CHROMOSOMES, HUMAN, PAIR 4; COHORT STUDIES; ELECTROCARDIOGRAPHY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECURRENCE; REGISTRIES;

EID: 84864763384     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.01.070     Document Type: Article

References (33)

1. W.M. Feinberg, J.L. Blackshear, A. Laupacis, R. Kronmal, R.G. Hart Prevalence, age distribution, and gender of patients with atrial fibrillation Analysis and implications Arch Intern Med 155 1995 469 473
2. W. Evans, P. Swann Lone auricular fibrillation Br Heart J 16 1954 189 194
3. R. Brugada, T. Tapscott, G.Z. Czernuszewicz Identification of a genetic locus for familial atrial fibrillation N Engl J Med 336 1997 905 911
4. Y.H. Chen, S.J. Xu, S. Bendahhou KCNQ1 gain-of-function mutation in familial atrial fibrillation Science 299 2003 251 254
5. L.Y. Chen, W.K. Shen Epidemiology of atrial fibrillation: a current perspective Heart Rhythm 4 2007 S1 S6
6. P. Coumel Paroxysmal atrial fibrillation: a disorder of autonomic tone? Eur Heart J 15 Suppl A 1994 9 16
7. M.H. Gollob, D.L. Jones, A.D. Krahn Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation N Engl J Med 354 2006 2677 2688
8. R. Otway, J.I. Vandenberg, G. Guo Stretch-sensitive KCNQ1 mutation: a link between genetic and environmental factors in the pathogenesis of atrial fibrillation? J Am Coll Cardiol 49 2007 578 586
9. D.M. Hodgson-Zingman, M.L. Karst, L.V. Zingman Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation N Engl J Med 359 2008 158 165
10. T.M. Olson, A.E. Alekseev, X.K. Liu Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation Hum Mol Genet 15 2006 2185 2191
11. D. Darbar, P.J. Kannankeril, B.S. Donahue Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation Circulation 117 2008 1927 1935
12. X. Zhang, S. Chen, S. Yoo Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death Cell 135 2008 1017 1027
13. D.F. Gudbjartsson, D.O. Arnar, A. Helgadottir Variants conferring risk of atrial fibrillation on chromosome 4q25 Nature 448 2007 353 357
14. D.F. Gudbjartsson, H. Holm, S. Gretarsdottir A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke Nat Genet 8 2009 876 878
15. E.J. Benjamin, K.M. Rice, D.E. Arking Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry Nat Genet 41 2009 879 881
16. P.T. Ellinor, K.L. Lunetta, N.L. Glazer Common variants in KCNN3 are associated with lone atrial fibrillation Nat Genet 42 2010 240 244
17. S. Kaab, D. Darbar, C. van Noord Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation Eur Heart J 30 2009 813 819
18. S.C. Body, C.D. Collard, S.K. Shernan Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery Circulation Cardiovasc Genet 2 2009 499 506
19. D. Husser, V. Adams, C. Piorkowski, G. Hindricks, A. Bollmann Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation J Am Coll Cardiol 55 2010 747 753
20. D. Darbar, A.A. Motsinger, M.D. Ritchie, J.V. Gainer, D.M. Roden Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation Heart Rhythm 4 2007 743 749
21. P. Dorian, M. Paquette, D. Newman Quality of life improves with treatment in the Canadian Trial of Atrial Fibrillation Am Heart J 143 2002 984 990
22. D.F. Gudbjartsson, D.O. Arnar, A. Helgadottir Variants conferring risk of atrial fibrillation on chromosome 4q25 Nature 488 2007 353 357
23. M.T. Mommersteeg, N.A. Brown, O.W. Prall Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium Circ Res 101 2007 902 909
24. J. Wang, E. Klysik, S. Sood, R.L. Johnson, X.H. Wehrens, J.F. Martin Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification Proc Natl Acad Sci U S A 107 2010 9753 9758
25. M. Haissaguerre, P. Jais, D.C. Shah Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins N Engl J Med 339 1998 659 666
26. S.A. Lubitz, M.F. Sinner, K.L. Lunetta Independent susceptibility markers for atrial fibrillation on chromosome 4q25 Circulation 122 2010 976 984
27. R.L. Abraham, T. Yang, M. Blair, D.M. Roden, D. Darbar Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation J Mol Cell Cardiol 48 2010 181 190
28. N. Voigt, A. Trausch, M. Knaut Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation Circ Arrhythm Electrophysiol 3 2010 472 480
29. P. Kirchhof, P.C. Kahr, S. Kaese PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression Circ Cardiovasc Genet 4 2011 123 133
30. A. Chinchilla, H. Daimi, E. Lozano-Velasco PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis Circ Cardiovasc Genet 4 2011 269 279
31. D. Burgner, S. Davila, W.B. Breunis A genome-wide association study identifies novel and functionally related susceptibility loci for Kawasaki disease PLoS Genet 5 2009 e1000319
32. X. Sun, H.F. Frierson, C. Chen Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer Nat Genet 37 2005 407 412
33. J. Vaglio, S.C. Rowan, T. Stubblefield, S. Carter, D.M. Roden, D. Darbar Genetic and clinical predictors of response to rate control therapy in patients with atrial fibrillation Circulation 118 2008 S828