MIRD pamphlet no. 23: Quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy

Journal of Nuclear Medicine

Volumn 53, Issue 8, 2012, Pages 1310-1325

  Dewaraja, Yuni K ^a   Frey, Eric C ^b   Sgouros, George ^b   Brill, A Bertrand ^c   Roberson, Peter ^a   Zanzonico, Pat B ^d   Ljungberg, Michael ^e  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e LUND UNIVERSITY   (Sweden)

Author keywords

3D dosimetry; Absorbed dose; MIRD; Patient specific dosimetry; Quantitative SPECT; Radionuclide therapy

Indexed keywords

ETIDRONIC ACID TC 99M; IODINE 131; RADIOISOTOPE; TECHNETIUM 99M;

CALIBRATION; CAMERA; COLLIMATOR; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DOSIMETRY; FILTRATION; HUMAN; IMAGE ANALYSIS; IMAGE DISPLAY; IMAGE QUALITY; IMAGE RECONSTRUCTION; IMAGE RETRIEVAL; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE DIAGNOSIS; RADIATION ATTENUATION; RADIATION DEPTH DOSE; RADIATION DETECTION; RADIATION DETECTOR; RADIATION DOSE; RADIATION SCATTERING; RADIOISOTOPE THERAPY; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THREE DIMENSIONAL IMAGING;

ARTIFACTS; DOCUMENTATION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; INDIVIDUALIZED MEDICINE; RADIOISOTOPES; RADIOMETRY; RADIOTHERAPY DOSAGE; SCATTERING, RADIATION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84864751150     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.100123     Document Type: Review

References (97)

1. International Commission on Radiation Units and Measurements (ICRU). Absorbed- Dose Specification in Nuclear Medicine. Bethesda, MD: ICRU; 2002. Report 67.
2. O'Donoghue JA. Implications of nonuniform tumor doses for radioimmunotherapy. J Nucl Med. 1999;40:1337-1341. (Pubitemid 29385643)
3. Dale RG. The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy. Br J Radiol. 1985;58:515-528. (Pubitemid 15018411)
4. Flux G, Bardiès M, Monsieurs M, Savolainen S, Strand SE, Lassmann M. The impact of PET and SPECT on dosimetry for targeted radionuclide therapy. Z Med Phys. 2006;16:47-59.
5. Siegel JA, Thomas SR, Stubbs JB, et al. MIRD pamphlet no. 16: techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates. J Nucl Med. 1999;40(suppl):37S-61S. (Pubitemid 29077103)
6. Bolch WE, Eckerman KF, Sgouros G, Thomas SR. MIRD pamphlet no. 21: a generalized schema for radiopharmaceutical dosimetry - standardization of nomenclature. J Nucl Med. 2009;50:477-484.
7. Snyder W, Ford M, Warner G, Watson S. "S", Absorbed Dose per Unit Cumulated Activity for Selected Radionuclides and Organs. New York, NY: Society of Nuclear Medicine; 1975. MIRD Pamphlet No. 11.
8. Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005;46:1023-1027. (Pubitemid 43733519)
9. Bolch WE, Bouchet LG, Robertson JS, et al. MIRD pamphlet no. 17: the dosimetry of nonuniform activity distributions - radionuclide S values at the voxel level. J Nucl Med. 1999;40(suppl):11S-36S. (Pubitemid 29044199)
10. Tsougos I, Loudos G, Georgoulias P, Theodorou K, Kappas C. Patient-specific internal radionuclide dosimetry. Nucl Med Commun. 2010;31:97-106.
11. 131I-tositumomab radioimmunotherapy: initial tumor dose-response results using 3-dimensional dosimetry including radiobiologic modeling. J Nucl Med. 2010;51:1155-1162.
12. 131I-anti-B1 antibody: assessment of tumor dose-response. J Nucl Med. 2003;44:260-268.
13. He B, Du Y, Segars WP, et al. Evaluation of quantitative imaging methods for organ activity and residence time estimation using a population of phantoms having realistic variations in anatomy and uptake. Med Phys. 2009;36:612-619.
14. 90Y Bremsstrahlung imaging for absorbed-dose assessment in high-dose radioimmunotherapy. J Nucl Med. 2010;51:1974-1978.
15. Hutton B, Nuyts J, Zaidi H. Iterative reconstruction methods. In: Zaidi H, ed. Quantitative Analysis in Nuclear Medicine Imaging. New York, NY: Springer; 2006:107-140.
16. Lalush DS, Wernick MN. Iterative image reconstruction. In: Wernick MN, Aarsvold JN, eds. Emission Tomography: The Fundamentals of PET and SPECT. San Diego, CA: Elsevier Academic Press; 2004:443-472.
17. 177Lu [DOTA0, Tyr3] octreotate therapy in patients with disseminated neuroendocrine tumors: analysis of dosimetry with impact on future therapeutic strategy. Cancer. 2010;116:1084-1092.
18. 99mTc SPECT/CT using ordered-subset expectation maximization with 3-dimensional resolution recovery, attenuation, and scatter correction. J NuclMed. 2010;51:921-928.
19. Willowson K, Bailey DL, Baldock C. Quantitative SPECT reconstruction using CT-derived corrections. Phys Med Biol. 2008;53:3099-3112. (Pubitemid 351892389)
20. He B, Frey EC. Effects of shortened acquisition time on accuracy and precision of quantitative estimates of organ activity. Med Phys. 2010;37:1807-1815.
21. Ogawa K, Harata Y, Ichihara T, Kubo A, Hashimoto S. A practical method for position-dependent Compton-scatter correction in single photon-emission CT. IEEE Trans Med Imaging. 1991;10:408-412. (Pubitemid 21727995)
22. Ljungberg M, Frey E, Sjögreen-Gleisner K, Liu X, Dewaraja Y, Strand SE. 3D absorbed dose calculations based on SPECT: evaluation for 111-In/90-Y therapy using Monte Carlo simulations. Cancer Biother Radiopharm. 2003;18:99-107. (Pubitemid 36307471)
23. Assié K, Dieudonné A, Gardin I, Vera P, Buvat I. A preliminary study of quantitative protocols in indium 111 SPECT using computational simulations and phantoms. IEEE Trans Nucl Sci. 2010;57:1096-1104.
24. Narita Y, Eberl S, Iida H, et al. Monte Carlo and experimental evaluation of accuracy and noise properties of two scatter correction methods for SPECT. Phys Med Biol. 1996;41:2481-2496. (Pubitemid 26376917)
25. 111In imaging: comparison of measurements and Monte Carlo simulations. Cancer Biother Radiopharm. 2007;22:136-142.
26. Buck AK, Nekolla S, Ziegler S, et al. SPECT/CT. J Nucl Med. 2008;49:1305-1319.
27. Cherry SR, Sorenson JA, Phelps ME. Physics in Nuclear Medicine. Philadelphia, PA: Saunders; 2003.
28. Ferrer L, Delpon G, Lisbona A, Bardiès M. Dosimetric impact of correcting count losses due to deadtime in clinical radioimmunotherapy trials involving iodine-131 scintigraphy. Cancer Biother Radiopharm. 2003;18:117-124. (Pubitemid 36307473)
29. Dewaraja YK, Wilderman SJ, Koral KF, Kaminski MS, Avram AM. Use of integrated SPECT/CT imaging for tumor dosimetry in I-131 radioimmunotherapy: a pilot patient study. Cancer Biother Radiopharm. 2009;24:417-426.
30. Delpon G, Ferrer L, Lisbona A, Bardiès M. Correction of count losses due to deadtime on a DST-XLi (SMVi-GE) camera during dosimetric studies in patients injected with iodine-131. Phys Med Biol. 2002;47:N79-N90.
31. Zasadny KR, Koral KF, Swailem FM. Dead time of an anger camera in dualenergy- window-acquisition mode. Med Phys. 1993;20:1115-1120. (Pubitemid 23249858)
32. 131I dual-energy-window-acquisition mode. Med Phys. 1998;25:85-91.
33. Dewaraja Y, Ljungberg M, Koral K. Effects of dead time and pile up on quantitative SPECT for I-131 dosimetric studies [abstract]. J Nucl Med. 2008;49(suppl):47P.
34. Shepp LA, Vardi Y. Maximum likelihood reconstruction for emission tomography. IEEE Trans Med Imaging. 1982;1:113-122. (Pubitemid 13557763)
35. Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging. 1994;13:601-609.
36. Tsui BM, Frey E, Zhao X, Lalush D, Johnston R, McCartney W. The importance and implementation of accurate 3D compensation methods for quantitative SPECT. Phys Med Biol. 1994;39:509-530. (Pubitemid 24149130)
37. Dewaraja YK, Koral KF, Fessler JA. Regularized reconstruction in quantitative SPECT using CT side information from hybrid imaging. Phys Med Biol. 2010;55:2523-2539.
38. Zaidi H, Hasegawa B. Attenuation correction strategies in emission tomography. In: Zaidi H, ed. Quantitative Analysis in Nuclear Medicine Imaging. New York, NY: Springer; 2006:167-204.
39. Frey E, Tsui B. Collimator-detector response compensation in SPECT. In: Zaidi H, ed. Quantitative Analysis in Nuclear Medicine Imaging. New York, NY: Springer; 2006:141-166.
40. Zaidi H, Koral K. Scatter correction strategies in emission tomography. In: Zaidi H, ed. Quantitative Analysis in Nuclear Medicine Imaging. New York, NY: Springer; 2006:205-235.
41. Bowsher JE, Floyd CE Jr. Treatment of Compton scattering in maximum-likelihood, expectation-maximization reconstructions of SPECT images. J Nucl Med. 1991;32:1285-1291.
42. Kinahan PE, Hasegawa BH, Beyer T. X-ray-based attenuation correction for positron emission tomography/computed tomography scanners. Semin Nucl Med. 2003;33:166-179. (Pubitemid 36859496)
43. Blankespoor S, Xu X, Kaiki K, et al. Attenuation correction of SPECT using x-ray CT on an emission-transmission CT system: myocardial perfusion assessment. IEEE Trans Nucl Sci. 1996;43:2263-2274. (Pubitemid 126771606)
44. King M, DeVries D, Pan TS, Pretorius P, Case J. An investigation of the filtering of TEW scatter estimates used to compensate for scatter with ordered subset reconstructions. IEEE Trans Nucl Sci. 1997;44:1140-1145. (Pubitemid 127827064)
45. Dewaraja YK, Ljungberg M, Fessler JA. 3-D Monte Carlo-based scatter compensation in quantitative I-131 SPECT reconstruction. IEEE Trans Nucl Sci. 2006;53:181-188.
46. Frey EC, Tsui B. A new method for modeling the spatially-variant, object-dependent scatter response function in SPECT. 1996 IEEE Nuclear Science Symposium Conference Record. 1997;2:1082-1086.
47. Beekman FJ, de Jong HW, van Geloven S. Efficient fully 3-D iterative SPECT reconstruction with Monte Carlo-based scatter compensation. IEEE Trans Med Imaging. 2002;21:867-877. (Pubitemid 35476591)
48. Ouyang J, El Fakhri G, Moore SC. Improved activity estimation with MCJOSEM versus TEW-JOSEM in 111In SPECT. Med Phys. 2008;35:2029-2040. (Pubitemid 351614818)
49. Shcherbinin S, Celler A, Belhocine T, Vanderwerf R, Driedger A. Accuracy of quantitative reconstructions in SPECT/CT imaging. Phys Med Biol. 2008;53:4595-4604.
50. Koral KF, Yendiki A, Lin Q, Dewaraja YK. Comparison of 3-D OSEM versus 1-D SAGE for focal total-activity quantification in I-131 SPECT with HE collimation. IEEE Trans Nucl Sci. 2005;52:154-158. (Pubitemid 40564966)
51. Koral KF, Yendiki A, Dewaraja YK. Recovery of total I-131 activity within focal volumes using SPECT and 3D OSEM. Phys Med Biol. 2007;52:777-790. (Pubitemid 46646446)
52. He B, Du Y, Song X, Segars WP, Frey EC. A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT. Phys Med Biol. 2005;50:4169-4185. (Pubitemid 41225264)
53. Song H, He B, Prideaux A, et al. Lung dosimetry for radioiodine treatment planning in the case of diffuse lung metastases. J Nucl Med. 2006;47:1985-1994. (Pubitemid 47544986)
54. Zanzonico P. PET-based biological imaging for radiation therapy treatment planning. Crit Rev Eukaryot Gene Expr. 2006;16:61-101.
55. Boudraa A, Zaidi H. Image segmentation techniques in nuclear medicine imaging. In: Zaidi H, ed. Quantitative Analysis in Nuclear Medicine Imaging. New York, NY: Springer; 2006:308-357.
56. Erdi YE, Wessels BW, Loew MH, Erdi AK. Threshold estimation in single photon emission computed tomography and planar imaging for clinical radioimmunotherapy. Cancer Res. 1995;55(suppl):5823s-5826s.
57. Erdi YE, Mawlawi O, Larson SM, et al. Segmentation of lung lesion volume by adaptive positron emission tomography image thresholding. Cancer. 1997;80:2505-2509. (Pubitemid 28009506)
58. Jentzen W, Freudenberg L, Eising EG, Heinze M, Brandau W, Bockisch A. Segmentation of PET volumes by iterative image thresholding. J Nucl Med. 2007;48:108-114. (Pubitemid 47555383)
59. de Wit TC, Xiao J, Nijsen JFW, et al. Hybrid scatter correction applied to quantitative holmium-166 SPECT. Phys Med Biol. 2006;51:4773-4787. (Pubitemid 44429843)
60. King MA, Glick SJ, Pretorius PH, et al. Attenuation, scatter, and spatial resolution compensation in SPECT. In: Wernick MN, Aarsvold JN, eds. Emission Tomography: The Fundamentals of PET and SPECT. San Diego, CA: Elsevier Academic Press; 2004:473-498.
61. 131I radionuclide therapy using patient-specific, 3-dimensional methods for SPECT reconstruction and absorbed dose calculation. J Nucl Med. 2005;46:840-849.
62. 123I brain SPECT imaging. Phys Med Biol. 2006;51:1269-1282.
63. Jentzen W. Experimental investigation of factors affecting the absolute recovery coefficients in iodine-124 PET lesion imaging. Phys Med Biol. 2010;55:2365-2398.
64. Soret M, Koulibaly PM, Darcourt J, Hapdey S, Buvat I. Quantitative accuracy of dopaminergic neurotransmission imaging with 123I SPECT. J Nucl Med. 2003;44:1184-1193. (Pubitemid 39663393)
65. Rousset O, Rahmim A, Alavi A, Zaidi H. Partial volume correction strategies in PET. PET Clin. 2007;2:235-249.
66. Shcherbinin S, Celler A. Assessment of the severity of partial volume effects and the performance of two template-based correction methods in a SPECT/CT phantom experiment. Phys Med Biol. 2011;56:5355-5371.
67. 99mTc-sestamibi with SPECT: experimental validation in a porcine model. J Nucl Med. 2001;42:772-779.
68. Vicini P, Brill AB, Stabin MG, Rescigno A. Kinetic modeling in support of radionuclide dose assessment. Semin Nucl Med. 2008;38:335-346. (Pubitemid 352033564)
69. D'Argenio DZ. Optimal sampling times for pharmacokinetic experiments. J Pharmacokinet Phar. 1981;9:739-756. (Pubitemid 12184821)
70. 124I PET and 3-dimensional-internal dosimetry (3D-ID) software. J Nucl Med. 2004;45:1366-1372.
71. He B, Frey EC. The impact of 3D volume of interest definition on accuracy and precision of activity estimation in quantitative SPECT and planar processing methods. Phys Med Biol. 2010;55:3535-3544.
72. Papavasileiou P, Flux GD, Flower MA, Guy MJ. An automated technique for SPECT marker-based image registration in radionuclide therapy. Phys Med Biol. 2001;46:2085-2097. (Pubitemid 32747064)
73. Papavasileiou P, Divoli A, Hatziioannou K, Flux GD. A generalized 4D image registration scheme for targeted radionuclide therapy dosimetry. Cancer Biother Radiopharm. 2007;22:160-165. (Pubitemid 46697379)
74. Sjögreen-Gleisner K, Rueckert D, Ljungberg M. Registration of serial SPECT/CT images for three-dimensional dosimetry in radionuclide therapy. Phys Med Biol. 2009;54:6181-6200.
75. 131I-tositumomab therapy of previously untreated lymphoma patients. J Nucl Med. 2003;44:457-464.
76. 90Y-ibritumomab tiuxetan radioimmunotherapy of patients with non-Hodgkin's lymphoma. Cancer Biother Radiopharm. 2008;23:53-64.
77. Lyman JT. Complication probability as assessed from dose-volume histograms. Radiat Res Suppl. 1985;8(suppl):S13-S19. (Pubitemid 16149302)
78. Niemierko A, Goitein M. Calculation of normal tissue complication probability and dose-volume histogram reduction schemes for tissues with a critical element architecture. Radiother Oncol. 1991;20:166-176.
79. Bentzen SM, Constine LS, Deasy JO, et al. Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): an introduction to the scientific issues. In J. Radiat Oncol. 2010;76(suppl):S3-S9.
80. Wessels BW, Konijnenberg MW, Dale RG, et al. MIRD pamphlet no. 20: the effect of model assumptions on kidney dosimetry and response implications for radionuclide therapy. J Nucl Med. 2008;49:1884-1899.
81. Lassmann M, Chiesa C, Flux G, Bardiès M. EANM Dosimetry Committee guidance document: good practice of clinical dosimetry reporting. Eur J Nucl Med Mol Imaging. 2011;38:192-200.
82. Xu XG, Chao T, Bozkurt A. VIP-Man: an image-based whole-body adult male model constructed from color photographs of the Visible Human Project for multi-particle Monte Carlo calculations. Health Phys. 2000;78:476-486. (Pubitemid 30210781)
83. Segars WP, Sturgeon G, Mendonca S, Grimes J, Tsui B. 4D XCAT phantom for multimodality imaging research. Med Phys. 2010;37:4902-4915.
84. Celler A, Farncombe T, Bever C, et al. Performance of the dynamic single photon emission computed tomography (dSPECT) method for decreasing or increasing activity changes. Phys Med Biol. 2000;45:3525-3543. (Pubitemid 32005272)
85. Furenlid LR, Wilson DW, Chen Y, et al. FastSPECT II: a second-generation high-resolution dynamic SPECT imager. IEEE Trans Nucl Sci. 2004;51:631-635.
86. Schramm N, Ebel G, Engeland U, Schurrat T, Behe M, Behr T. High-resolution SPECT using multipinhole collimation. IEEE Trans Nucl Sci. 2003;50:315-320.
87. Beekman FJ, van der Have F, Vastenhouw B, et al. U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice. J Nucl Med. 2005;46:1194-1200. (Pubitemid 43741082)
88. Bocher M, Blevis IM, Tsukerman L, Shrem Y, Kovalski G, Volokh L. A fast cardiac gamma camera with dynamic SPECT capabilities: design, system validation and future potential. Eur J Nucl Med Mol Imaging. 2010;37:1887-1902.
89. Wong WH, Li H, Uribe J. A high count rate position decoding and energy measuring method for nuclear cameras using Anger logic detectors. IEEE Trans Nucl Sci. 1998;45:1122-1127. (Pubitemid 128739170)
90. Shah AP, Bolch WE, Rajon DA, Patton PW, Jokisch DW. A paired-image radiation transport model for skeletal dosimetry. J Nucl Med. 2005;46:344-353. (Pubitemid 43073446)
91. 124I PET-based 3D-RD dosimetry for a pediatric thyroid cancer patient: real-time treatment planning and methodologic comparison. J Nucl Med. 2009;50:1844-1847.
92. Hobbs RF, Baechler S, Wahl RL, et al. Arterial wall dosimetry for non-Hodgkin lymphoma patients treated with radioimmunotherapy. J Nucl Med. 2010;51:368-375.
93. Bäck T, Jacobsson L. The alpha-camera: a quantitative digital autoradiography technique using a charge-coupled device for ex vivo high-resolution bioimaging of alpha-particles. J Nucl Med. 2010;51:1616-1623.
94. Ljunggren K, Liu X, Erlandsson K, Ljungberg M, Salford L, Strand SE. Absorbed dose distribution in glioma tumors in rat brain after therapeutic intratumoral injection of 201Tl-chloride. Cancer Biother Radiopharm. 2004;19:562-569. (Pubitemid 39546295)
95. 90Y SPECT based on experimental phantom studies. Phys Med Biol. 2008; 53:5689-5703.
96. Han EY, Bolch WE, Eckerman KF. Revisions to the ORNL series of adult and pediatric computational phantoms for use with the MIRD schema. Health Phys. 2006;90:337-356.
97. Ljungberg M, Strand SE. A Monte Carlo program for the simulation of scintillation camera characteristics. Comput Methods Programs Biomed. 1989;29:257-272. (Pubitemid 20610320)