Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase

CNS Neuroscience and Therapeutics

Volumn 18, Issue 8, 2012, Pages 683-690

  Hu, Wei Wei ^a   Fang, Qi ^a,b   Xu, Zheng Hao ^a   Yan, Hai Jing ^a   He, Ping ^a   Zhong, Kai ^a   Fan, Yan Ying ^a   Yang, Ying ^a   Zhang, Xiang Nan ^a   Zhang, Chun Yang ^a   Ohtsu, Hiroshi ^c   Xu, Tian Le ^b   Chen, Zhong ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Gamma aminobutyric acid; Glutamine synthetase; H1 antihistamine; Seizure susceptibility

Indexed keywords

4 AMINOBUTYRIC ACID; DIPHENHYDRAMINE; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; HISTIDINE DECARBOXYLASE; MEPYRAMINE; METHIONINE SULFOXIMINE; PENTETRAZOLE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINDLING; KNOCKOUT MOUSE; LONG TERM CARE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; SEIZURE SUSCEPTIBILITY; SUPPLEMENTATION; WILD TYPE;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONVULSANTS; ELECTROSHOCK; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE-AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; HISTAMINE H1 ANTAGONISTS; HISTIDINE DECARBOXYLASE; IMMUNOHISTOCHEMISTRY; KINDLING, NEUROLOGIC; MALE; METHIONINE SULFOXIMINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PENTYLENETETRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84864750889     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2012.00356.x     Document Type: Article

References (41)

1. Churchill JA, Gammon GD. The effect of antihistaminic drugs on convulsive seizures. J Am Med Assoc 1949;141:18-21.
2. Fujii Y, Tanaka T, Harada C, Hirai T, Kamei C. Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats. Brain Res 2003;991:258-261.
3. Yawata I, Tanaka K, Nakagawa Y, Watanabe Y, Murashima YL, Nakano K. Role of histaminergic neurons in development of epileptic seizures in EL mice. Brain Res Mol Brain Res 2004;132:13-17.
4. Kamei C, Ohuchi M, Sugimoto Y, Okuma C. Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats. Brain Res 2000;887:183-186.
5. Thundiyil JG, Kearney TE, Olson KR. Evolving epidemiology of drug-induced seizures reported to a Poison Control Center System. J Med Toxicol 2007;3:15-19.
6. Chen Z, Li WD, Zhu LJ, Shen YJ, Wei EQ. Effects of histidine, a precursor of histamine, on pentylenetetrazole-induced seizures in rats. Acta Pharmacol Sin 2002;23:361-366.
7. Chen Z, Li Z, Sakurai E, et al. Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice. Brain Res 2003;968:162-166.
8. Eid T, Thomas MJ, Spencer DD, et al. Loss of glutamine synthetase in the human epileptogenic hippocampus: Possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy. Lancet 2004;363:28-37.
9. Eid T, Williamson A, Lee TS, Petroff OA, de Lanerolle NC. Glutamate and astrocytes-key players in human mesial temporal lobe epilepsy? Epilepsia 2008;49(Suppl 2):42-52.
10. van Gassen KL, van der Hel WS, Hakvoort TB, Lamers WH, de Graan PN. Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures. Genes Brain Behav 2009;8:290-295.
11. Bak LK, Schousboe A, Waagepetersen HS. The glutamate/GABA-glutamine cycle: Aspects of transport, neurotransmitter homeostasis and ammonia transfer. J Neurochem 2006;98:641-653.
12. Battaglioli G, Martin DL. GABA synthesis in brain slices is dependent on glutamine produced in astrocytes. Neurochem Res 1991;16:151-156.
13. Eid T, Ghosh A, Wang Y, et al. Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats. Brain 2008;131:2061-2070.
14. Rodriguez J, Moran J, Blanco I, Patel AJ. Effect of histamine on the development of astroglial cells in culture. Neurochem Res 1989;14:693-700.
15. Jin CL, Yang LX, Wu XH, et al. Effects of carnosine on amygdaloid-kindled seizures in Sprague-Dawley rats. Neuroscience 2005;135:939-947.
16. Hosli L, Hosli E, Schneider U, Wiget W. Evidence for the existence of histamine H1- and H2-receptors on astrocytes of cultured rat central nervous system. Neurosci Lett 1984;48:287-291.
17. Paxinos G, Watson C, editors. The rat brain stereotaxic coordinates. Sydney: Academic Press, 1986.
18. Wang S, Wu DC, Ding MP, Li Q, Zhu-Ge ZB, Zhang SH, Chen Z. Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague-Dawley rats. Neurobiol Dis 2008;29:52-58.
19. Wu DC, Xu ZH, Wang S, et al. Time-dependent effect of low-frequency stimulation on amygdaloid-kindling seizures in rats. Neurobiol Dis 2008;31:74-79.
20. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972;32:281-294.
21. Nishida N, Huang ZL, Mikuni N, Miura Y, Urade Y, Hashimoto N. Deep brain stimulation of the posterior hypothalamus activates the histaminergic system to exert antiepileptic effect in rat pentylenetetrazol model. Exp Neurol 2007;205:132-144.
22. Galic MA, Riazi K, Heida JG, et al. Postnatal inflammation increases seizure susceptibility in adult rats. J Neurosci 2008;28:6904-6913.
23. Lian XY, Khan FA, Stringer JL. Fructose-1, 6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats. J Neurosci 2007;27:12007-12011.
24. Fischer W, Kittner H, Regenthal R, Malinowska B, Schlicker E. Anticonvulsant and sodium channel blocking activity of higher doses of clenbuterol. Naunyn Schmiedebergs Arch Pharmacol 2001;363:182-192.
25. Zhu YY, Zhu-Ge ZB, Wu DC, Wang S, Liu LY, Ohtsu H, Chen Z. Carnosine inhibits pentylenetetrazol-induced seizures by histaminergic mechanisms in histidine decarboxylase knock-out mice. Neurosci Lett 2007;416:211-216.
26. Gilby KL, Sydserff S, Patey AM, Thorne V, St-Onge V, Jans J, McIntyre DC. Postnatal epigenetic influences on seizure susceptibility in seizure-prone versus seizure-resistant rat strains. Behav Neurosci 2009;123:337-346.
27. Ohtsu H, Tanaka S, Terui T, et al. Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett 2001;502:53-56.
28. Huang JH, Huang XH, Chen ZY, Zheng QS, Sun RY. Dose conversion among different animals and healthy volunteers in pharmacological study. Chin J Clin Pharmacol Ther 2004;9:1069-1072.
29. Olson KR, Kearney TE, Dyer JE, Benowitz NL, Blanc PD. Seizures associated with poisoning and drug overdose. Am J Emerg Med 1994;12:392-395.
30. Yokoyama H, Sato M, Iinuma K, Onodera K, Watanabe T. Centrally acting histamine H1 antagonists promote the development of amygdala kindling in rats. Neurosci Lett 1996;217:194-196.
31. Simons FE. Advances in H1-antihistamines. N Engl J Med 2004;351:2203-2217.
32. Nobles ST. Delmar's drug reference for health care professionals. Australia: Cengage Learning, 2001.
33. Santiago-Palma J, Fischberg D, Kornick C, Khjainova N, Gonzales G. Diphenhydramine as an analgesic adjuvant in refractory cancer pain. J Pain Symptom Manage 2001;22:699-703.
34. Kelly DW, Slikker W Jr. The metabolism and elimination of pyrilamine maleate in the rat. Drug Metab Dispos 1987;15:460-465.
35. Toothaker RD, Barker SH, Gillen MV, Helsinger SA, Kindberg CG, Hunt TL, Powell JH. Absence of pharmacokinetic interaction between orally co-administered naproxen sodium and diphenhydramine hydrochloride. Biopharm Drug Dispos 2000;21:229-233.
36. Yokoyama H. The role of central histaminergic neuron system as an anticonvulsive mechanism in developing brain. Brain Dev 2001;23:542-547.
37. Wang Y, Zaveri HP, Lee TS, Eid T. The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: A video-intracranial electroencephalographic study. Exp Neurol 2009;220:293-302.
38. Liebschutz J, Airoldi L, Brownstein MJ, Chinn NG, Wurtman RJ. Regional distribution of endogenous and parenteral glutamate, aspartate and glutamine in rat brain. Biochem Pharmacol 1977;26:443-446.
39. Wang L, Maher TJ, Wurtman RJ. Oral L-glutamine increases GABA levels in striatal tissue and extracellular fluid. FASEB J 2007;21:1227-1232.
40. Liang SL, Carlson GC, Coulter DA. Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1. J Neurosci 2006;26:8537-8548.
41. Ortinski PI, Dong J, Mungenast A, et al. Selective induction of astrocytic gliosis generates deficits in neuronal inhibition. Nat Neurosci 2010;13:584-591.