메뉴 건너뛰기




Volumn 21, Issue 4, 2007, Pages 1227-1232

Oral L-glutamine increases GABA levels in striatal tissue and extracellular fluid

Author keywords

Glutamate; Hepatic encephalopathy; Microdialysis; Neurotransmitter precursor

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMIC ACID; GLUTAMINE; N METHYL DEXTRO ASPARTIC ACID;

EID: 33947656412     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7495com     Document Type: Article
Times cited : (53)

References (44)
  • 1
    • 0019103386 scopus 로고
    • Precursor control of neurotransmitter synthesis
    • Wurtman, R. J., Hefti, F., and Melamed, E. (1980) Precursor control of neurotransmitter synthesis. Pharmacol. Rev. 32, 315-335
    • (1980) Pharmacol. Rev , vol.32 , pp. 315-335
    • Wurtman, R.J.1    Hefti, F.2    Melamed, E.3
  • 2
    • 0005686927 scopus 로고
    • Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions
    • Melamed, E., Hefti, F., and Wurtman, R. J. (1980) Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions. Proc. Natl. Acad. Sci. U. S. A. 77, 4305-4309
    • (1980) Proc. Natl. Acad. Sci. U. S. A , vol.77 , pp. 4305-4309
    • Melamed, E.1    Hefti, F.2    Wurtman, R.J.3
  • 3
    • 0024162185 scopus 로고
    • Tyrosine: Effects on catecholamine release
    • Acworth, I. N., During, M. J., and Wurtman, R. J. (1988) Tyrosine: effects on catecholamine release. Brain Res. Bull. 21, 473-477
    • (1988) Brain Res. Bull , vol.21 , pp. 473-477
    • Acworth, I.N.1    During, M.J.2    Wurtman, R.J.3
  • 4
    • 0015216394 scopus 로고
    • Brain serotonin content: Physiological dependence on plasma tryptophan levels
    • Fernstrom, J. D., and Wurtman, R. J. (1971) Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 173, 149-152
    • (1971) Science , vol.173 , pp. 149-152
    • Fernstrom, J.D.1    Wurtman, R.J.2
  • 5
    • 0025131892 scopus 로고
    • Serotonin release varies with brain tryptophan levels
    • Schaechter, J. D., and Wurtman, R. J. (1990) Serotonin release varies with brain tryptophan levels. Brain Res. 532, 203-210
    • (1990) Brain Res , vol.532 , pp. 203-210
    • Schaechter, J.D.1    Wurtman, R.J.2
  • 6
    • 33745893228 scopus 로고    scopus 로고
    • The glutamate/GABA-glutamine cycle: Aspects of transport, neurotransmitter homeostasis and ammonia transfer
    • Bak, L. K., Schousboe, A., and Waagepetersen, H. S. (2006) The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer. J. Neurochem. 98, 641-653
    • (2006) J. Neurochem , vol.98 , pp. 641-653
    • Bak, L.K.1    Schousboe, A.2    Waagepetersen, H.S.3
  • 7
    • 0002205552 scopus 로고
    • Regulation of amino acid availability to brain: Selective control mechanisms for glutamate
    • Filer, L. J, Jr, ed pp, Raven Press, New York, NY
    • Pardridge, W. M. (1979) Regulation of amino acid availability to brain: selective control mechanisms for glutamate. In Glutamic Acid: Advances in Biochemistry and Physiology (Filer, L. J., Jr., ed) pp. 125-137, Raven Press, New York, NY
    • (1979) Glutamic Acid: Advances in Biochemistry and Physiology , pp. 125-137
    • Pardridge, W.M.1
  • 8
    • 0023634699 scopus 로고
    • Kinetics of neutral amino acid transport across the blood-brain barrier
    • Smith, Q. R., Momma, S., Aoyagi, M., and Rapoport, S. I. (1987) Kinetics of neutral amino acid transport across the blood-brain barrier. J. Neurochem. 49, 1651-1658
    • (1987) J. Neurochem , vol.49 , pp. 1651-1658
    • Smith, Q.R.1    Momma, S.2    Aoyagi, M.3    Rapoport, S.I.4
  • 9
    • 0028803353 scopus 로고
    • N-system amino acid transport at the blood-CSF barrier
    • Keep, R. F., and Xiang, J. (1995) N-system amino acid transport at the blood-CSF barrier. J. Neurochem. 65, 2571-2576
    • (1995) J. Neurochem , vol.65 , pp. 2571-2576
    • Keep, R.F.1    Xiang, J.2
  • 10
    • 0031740964 scopus 로고    scopus 로고
    • Glutamine uptake at the blood-brain barrier is mediated by N-system transport
    • Ennis, S. R., Kawai, N., Ren, X. D., Abdelkarim, G. E., and Keep, R. F. (1998) Glutamine uptake at the blood-brain barrier is mediated by N-system transport. J. Neurochem. 71, 2565-2573
    • (1998) J. Neurochem , vol.71 , pp. 2565-2573
    • Ennis, S.R.1    Kawai, N.2    Ren, X.D.3    Abdelkarim, G.E.4    Keep, R.F.5
  • 11
    • 0019731734 scopus 로고
    • Glutamate as a precursor of GABA in rat brain and peripheral tissues
    • White, H. L. (1981) Glutamate as a precursor of GABA in rat brain and peripheral tissues. Mol. Cell Biochem. 39, 253-259
    • (1981) Mol. Cell Biochem , vol.39 , pp. 253-259
    • White, H.L.1
  • 12
    • 21344464906 scopus 로고    scopus 로고
    • Suppression of glial glutamine release to the extracellular fluid studied in vivo by NMR and microdialysis in hyperammonemic rat brain
    • Kanamori, K., and Ross, B. D. (2005) Suppression of glial glutamine release to the extracellular fluid studied in vivo by NMR and microdialysis in hyperammonemic rat brain. J. Neurochem. 94, 74-85
    • (2005) J. Neurochem , vol.94 , pp. 74-85
    • Kanamori, K.1    Ross, B.D.2
  • 13
    • 0027395911 scopus 로고
    • Regulation of gamma-aminobutyric acid synthesis in the brain
    • Martin, D. L., and Rimvall, K. (1993) Regulation of gamma-aminobutyric acid synthesis in the brain. J. Neurochem. 60, 395-407
    • (1993) J. Neurochem , vol.60 , pp. 395-407
    • Martin, D.L.1    Rimvall, K.2
  • 14
    • 0031438061 scopus 로고    scopus 로고
    • Nutrient regulation of gamma-aminobutyric acid release from islet beta cells
    • Smismans, A., Schuit, F., and Pipeleers, D. (1997) Nutrient regulation of gamma-aminobutyric acid release from islet beta cells. Diabetologia 40, 1411-1415
    • (1997) Diabetologia , vol.40 , pp. 1411-1415
    • Smismans, A.1    Schuit, F.2    Pipeleers, D.3
  • 15
    • 0029887177 scopus 로고    scopus 로고
    • Glutamine stimulates GABA synthesis in synaptosomes but other putative astrocyte-toneuron shuttle substrates do not
    • Battaglioli, G., and Martin, D. L. (1996) Glutamine stimulates GABA synthesis in synaptosomes but other putative astrocyte-toneuron shuttle substrates do not. Neurosci. Lett. 209, 129-133
    • (1996) Neurosci. Lett , vol.209 , pp. 129-133
    • Battaglioli, G.1    Martin, D.L.2
  • 16
    • 0025779184 scopus 로고
    • GABA synthesis in brain slices is dependent on glutamine produced in astrocytes
    • Battaglioli, G., and Martin, D. L. (1991) GABA synthesis in brain slices is dependent on glutamine produced in astrocytes. Neurochem. Res. 16, 151-156
    • (1991) Neurochem. Res , vol.16 , pp. 151-156
    • Battaglioli, G.1    Martin, D.L.2
  • 17
    • 0037390782 scopus 로고    scopus 로고
    • Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: Further evidence for metabolic compartmentalization
    • Rae, C., Hare, N., Bubb, W. A., McEwan, S. R., Broer, A., McQuillan, J. A., Balcar, V. J., Conigrave, A. D., and Broer, S. (2003) Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentalization. J. Neurochem. 85, 503-514
    • (2003) J. Neurochem , vol.85 , pp. 503-514
    • Rae, C.1    Hare, N.2    Bubb, W.A.3    McEwan, S.R.4    Broer, A.5    McQuillan, J.A.6    Balcar, V.J.7    Conigrave, A.D.8    Broer, S.9
  • 18
    • 0035940723 scopus 로고    scopus 로고
    • Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition
    • Patel, A. B., Rothman, D. L., Cline, G. W., and Behar, K. L. (2001) Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Res. 919, 207-220
    • (2001) Brain Res , vol.919 , pp. 207-220
    • Patel, A.B.1    Rothman, D.L.2    Cline, G.W.3    Behar, K.L.4
  • 20
    • 0017331412 scopus 로고
    • Regional distribution of endogenous and parenteral glutamate, aspartate and glutamine in rat brain
    • Liebschutz, J., Airoldi, L., Brownstein, M. J., Chinn, N. G., and Wurtman, R. J. (1977) Regional distribution of endogenous and parenteral glutamate, aspartate and glutamine in rat brain. Biochem. Pharmacol. 26, 443-446
    • (1977) Biochem. Pharmacol , vol.26 , pp. 443-446
    • Liebschutz, J.1    Airoldi, L.2    Brownstein, M.J.3    Chinn, N.G.4    Wurtman, R.J.5
  • 22
    • 0028208640 scopus 로고
    • Measurement of GABA in rat brain microdialysates using o-phthaldialdehyde-sulphite derivatization and high-performance liquid chromatography with electrochemical detection
    • Smith, S., and Sharp, T. (1994) Measurement of GABA in rat brain microdialysates using o-phthaldialdehyde-sulphite derivatization and high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B. 652, 228-233
    • (1994) J. Chromatogr. B , vol.652 , pp. 228-233
    • Smith, S.1    Sharp, T.2
  • 23
    • 0023774407 scopus 로고
    • An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates
    • Donzanti, B. A., and Yamamoto, B. K. (1988) An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates. Life Sci. 43, 913-922
    • (1988) Life Sci , vol.43 , pp. 913-922
    • Donzanti, B.A.1    Yamamoto, B.K.2
  • 25
    • 0029099953 scopus 로고
    • Regulation of glutaminase activity and glutamine metabolism
    • Curthoys, N. P., and Watford, M. (1995) Regulation of glutaminase activity and glutamine metabolism. Annu. Rev. Nutr. 15, 133-159
    • (1995) Annu. Rev. Nutr , vol.15 , pp. 133-159
    • Curthoys, N.P.1    Watford, M.2
  • 26
    • 3042817423 scopus 로고    scopus 로고
    • Quantitative determination of extracellular glutamine concentration in rat brain, and its elevation in vivo by system A transport inhibitor, alpha-(methylamino) isobutyrate
    • Kanamori, K., and Ross, B. D. (2004) Quantitative determination of extracellular glutamine concentration in rat brain, and its elevation in vivo by system A transport inhibitor, alpha-(methylamino) isobutyrate. J. Neurochem. 90, 203-210
    • (2004) J. Neurochem , vol.90 , pp. 203-210
    • Kanamori, K.1    Ross, B.D.2
  • 27
    • 0000027898 scopus 로고
    • Ontogenetic development of glutamate and GABA metabolizing enzymes in cultured cerebral cortex interneurons and in cerebral cortex in vivo
    • Larsson, O. M., Drejer, J., Kvamme, E., Svenneby, G., Hertz, L., and Schousboe, A. (1985) Ontogenetic development of glutamate and GABA metabolizing enzymes in cultured cerebral cortex interneurons and in cerebral cortex in vivo. Int. J. Dev. Neurosci. 3, 177-185
    • (1985) Int. J. Dev. Neurosci , vol.3 , pp. 177-185
    • Larsson, O.M.1    Drejer, J.2    Kvamme, E.3    Svenneby, G.4    Hertz, L.5    Schousboe, A.6
  • 28
    • 0032842197 scopus 로고    scopus 로고
    • The GABA paradox: Multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent
    • Waagepetersen, H. S., Sonnewald, U., and Schousboe, A. (1999) The GABA paradox: multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent. J. Neurochem. 73, 1335-1342
    • (1999) J. Neurochem , vol.73 , pp. 1335-1342
    • Waagepetersen, H.S.1    Sonnewald, U.2    Schousboe, A.3
  • 30
    • 0016351736 scopus 로고
    • Metabolic compartmentation of glutamate associated with the formation of gamma-aminobutyrate
    • Patel, A. J., Johnson, A. L., and Balazs, R. (1974) Metabolic compartmentation of glutamate associated with the formation of gamma-aminobutyrate. J. Neurochem. 23, 1271-1279
    • (1974) J. Neurochem , vol.23 , pp. 1271-1279
    • Patel, A.J.1    Johnson, A.L.2    Balazs, R.3
  • 31
    • 0020318490 scopus 로고
    • Metabolism and brain uptake of gamma-aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats
    • Zeneroli, M. L., Iuliano, E., Racagni, G., and Baraldi, M. (1982) Metabolism and brain uptake of gamma-aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats. J. Neurochem. 38, 1219-1222
    • (1982) J. Neurochem , vol.38 , pp. 1219-1222
    • Zeneroli, M.L.1    Iuliano, E.2    Racagni, G.3    Baraldi, M.4
  • 32
    • 0026322158 scopus 로고
    • Hepatic failure and coma after liver resection is reversed by manipulation of gut contents: The role of endotoxin
    • Van Leeuwen, P. A., Hong, R. W., Rounds, J. D., Rodrick, M. L., and Wilmore, D. (1991) Hepatic failure and coma after liver resection is reversed by manipulation of gut contents: the role of endotoxin. Surgery 110, 169-174
    • (1991) Surgery , vol.110 , pp. 169-174
    • Van Leeuwen, P.A.1    Hong, R.W.2    Rounds, J.D.3    Rodrick, M.L.4    Wilmore, D.5
  • 33
    • 0026640402 scopus 로고
    • Cerebral cortex ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat
    • Dejong, C. H., Kampman, M. T., Deutz, N. E., and Soeters, P. B. (1992) Cerebral cortex ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat. J. Neurochem. 59, 1071-1079
    • (1992) J. Neurochem , vol.59 , pp. 1071-1079
    • Dejong, C.H.1    Kampman, M.T.2    Deutz, N.E.3    Soeters, P.B.4
  • 35
    • 0031054156 scopus 로고    scopus 로고
    • The effects of ammonia and portal-systemic shunting on brain metabolism, neurotransmission and intracranial hypertension in hyperammonaemia-induced encephalopathy
    • Vogels, B. A., van Steynen, B., Maas, M. A., Jorning, G. G., and Chamuleau, R. A. (1997) The effects of ammonia and portal-systemic shunting on brain metabolism, neurotransmission and intracranial hypertension in hyperammonaemia-induced encephalopathy. J. Hepatol. 26, 387-395
    • (1997) J. Hepatol , vol.26 , pp. 387-395
    • Vogels, B.A.1    van Steynen, B.2    Maas, M.A.3    Jorning, G.G.4    Chamuleau, R.A.5
  • 36
    • 0018213324 scopus 로고
    • Brain energy metabolism and alterations of transmitter profiles in acute hepatic coma
    • Funovics, J. M., and Fischer, J. E. (1978) Brain energy metabolism and alterations of transmitter profiles in acute hepatic coma. J. Neural. Transm. Suppl. 14, 61-67
    • (1978) J. Neural. Transm. Suppl , vol.14 , pp. 61-67
    • Funovics, J.M.1    Fischer, J.E.2
  • 38
    • 0036096070 scopus 로고    scopus 로고
    • Direct and indirect enhancement of GABAergic neurotransmission by ammonia: Implications for the pathogenesis of hyperammonemic syndromes
    • Basile, A. S. (2002) Direct and indirect enhancement of GABAergic neurotransmission by ammonia: implications for the pathogenesis of hyperammonemic syndromes. Neurochem. Int. 41, 115-122
    • (2002) Neurochem. Int , vol.41 , pp. 115-122
    • Basile, A.S.1
  • 39
    • 0026486598 scopus 로고
    • Enhanced GABA release in cerebral cortical slices derived from rats with thioacetamide-induced hepatic encephalopathy
    • Wysmyk, U., Oja, S. S., Saransaari, P., and Albrecht, J. (1992) Enhanced GABA release in cerebral cortical slices derived from rats with thioacetamide-induced hepatic encephalopathy. Neurochem. Res. 17, 1187-1190
    • (1992) Neurochem. Res , vol.17 , pp. 1187-1190
    • Wysmyk, U.1    Oja, S.S.2    Saransaari, P.3    Albrecht, J.4
  • 40
    • 0028045735 scopus 로고
    • Brain ion and amino acid contents during edema development in hepatic encephalopathy
    • Hilgier, W., and Olson, J. E. (1994) Brain ion and amino acid contents during edema development in hepatic encephalopathy. J. Neurochem. 62, 197-204
    • (1994) J. Neurochem , vol.62 , pp. 197-204
    • Hilgier, W.1    Olson, J.E.2
  • 41
    • 0023176895 scopus 로고
    • Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy
    • Lavoie, J., Giguere, J. F., Layrargues, G. P., and Butterworth, R. F. (1987) Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. J. Neurochem. 49, 692-697
    • (1987) J. Neurochem , vol.49 , pp. 692-697
    • Lavoie, J.1    Giguere, J.F.2    Layrargues, G.P.3    Butterworth, R.F.4
  • 42
    • 0033363308 scopus 로고    scopus 로고
    • Anxiety: At the intersection of genes and experience
    • Anagnostaras, S. G., Craske, M. G., and Fanselow, M. S. (1999) Anxiety: at the intersection of genes and experience. Nat. Neurosci. 2, 780-782
    • (1999) Nat. Neurosci , vol.2 , pp. 780-782
    • Anagnostaras, S.G.1    Craske, M.G.2    Fanselow, M.S.3
  • 43
    • 0037112230 scopus 로고    scopus 로고
    • GABA becomes exciting
    • Kohling, R. (2002) GABA becomes exciting. Science 298, 1350-1351
    • (2002) Science , vol.298 , pp. 1350-1351
    • Kohling, R.1
  • 44
    • 0025786847 scopus 로고
    • Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients
    • Benes, F. M., McSparren, J., Bird, E. D., SanGiovanni, J. P., and Vincent, S. L. (1991) Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch. Gen. Psychiatry 48, 996-1001
    • (1991) Arch. Gen. Psychiatry , vol.48 , pp. 996-1001
    • Benes, F.M.1    McSparren, J.2    Bird, E.D.3    SanGiovanni, J.P.4    Vincent, S.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.