Metabolic acidosis increases fibroblast growth factor 23 in neonatal mouse bone

American Journal of Physiology - Renal Physiology

Volumn 303, Issue 3, 2012, Pages

  Krieger, Nancy S ^a   Culbertson, Christopher D ^a   Kyker Snowman, Kelly ^a   Bushinsky, David A ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Chronic kidney disease; Osteoblasts

Indexed keywords

BICARBONATE; FIBROBLAST GROWTH FACTOR 23; MESSENGER RNA; PHOSPHATE;

ANIMAL TISSUE; ARTICLE; BONE; BONE CELL; CALVARIA; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; HEART LEFT VENTRICLE HYPERTROPHY; KIDNEY FUNCTION; METABOLIC ACIDOSIS; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 84864750137     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00199.2012     Document Type: Article

References (36)

1. Anderson PH, Atkins GJ. The skeleton as an intracrine organ for vitamin D metabolism. Mol Aspects Med 29: 397-406, 2008.
2. Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, Mohammadi M, Sirkis R, Naveh-Many T, Silver J. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 117: 4003-4008, 2007.
3. Bushinsky DA, Lechleider RJ. Mechanism of proton-induced bone calcium release: calcium carbonate-dissolution. Am J Physiol Renal Fluid Electrolyte Physiol 253: F998-F1005, 1987.
4. Bushinsky DA, Wolbach W, Sessler NE, Mogilevsky R, Levi-Setti R. Physicochemical effects of acidosis on bone calcium flux and surface ion composition. J Bone Miner Res 8: 93-102, 1993.
5. Cancela AL, Oliveira RB, Graciolli FG, dos Reis LM, Barreto F, Barreto DV, Cuppari L, Jorgetti V, Carvalho AB, Canziani ME, Moyses RM. Fibroblast growth factor 23 in hemodialysis patients: effects of phosphate binder, calcitriol and calcium concentration in the dialysate. Nephron Clin Pract 117: 74-82, 2011.
6. Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiér-rez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-om, Kusek JW, Keane MG, Wolf M. FGF23 induces left ventricular hypertrophy. J Clin Invest 121: 4393-4408, 2011.
7. Ferrari SL, Bonjour JP, Rizzoli R. Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. J Clin Endocrinol Metab 90: 1519-1524, 2005.
8. Frick KK, Bushinsky DA. Metabolic acidosis stimulates RANK ligand RNA expression in bone through a cyclooxygenase dependent mechanism. J Bone Miner Res 18: 1317-1325, 2003.
9. Frick KK, Krieger NS, Nehrke K, Bushinsky DA. Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1. J Bone Miner Res 24: 305-313, 2009.
10. Gutierrez O, Isakova T, Rhee E, Shah A, Holmes J, Collerone G, Jueppner HW, Wolf M. Fibroblast growth factor-23 mitigates hyper-phosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol 16: 2205-2215, 2005.
11. Isakova T, Wahl P, Vargas GS, Gutierrez OM, Scialla J, Xie H, Appleby D, Nessel L, Bellovich K, Chen J, Hamm L, Gadegbeku C, Horwitz E, Townsend RR, Anderson CAM, Lash JP, Hsu Cy Leonard MB, Wolf M. Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int 79: 1370-1378, 2011.
12. Isakova T, Xie H, Yang W, Xie D, Anderson AH, Scialla J, Wahl P, Gutierrez O, Steigerwalt S, He J, Schwartz S, Lo J, Ojo A, Sond-heimer J, Hsu Cy Lash J, Leonard M, Kusek JW, Feldman HI, Wolf M. Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients With chronic kidney disease. JAMA 305: 2432-2439, 2011.
13. Ix JH, Shlipak MG, Wassel CL, Whooley MA. Fibroblast growth factor-23 and early decrements in kidney function: the Heart and Soul Study. Nephrol Dial Transplant 25: 993-997, 2010.
14. Kawata T, Imanishi Y, Kobayashi K, Miki T, Arnold A, Inaba M, Nishizawa Y. Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism. J Am Soc Nephrol 18: 2683-2688, 2007.
15. Krieger NS, Bushinsky DA. Pharmacologic inhibition of intracellular calcium release blocks acid-induced bone resorption. Am J Physiol Renal Physiol 300: F91-F97, 2011.
16. Krieger NS, Frick KK, Bushinsky DA. Mechanism of acid-induced bone resorption. Curr Opin Nephrol Hypertens 13: 423-436, 2004.
17. Krieger NS, Hefley TJ. Differential effects of parathyroid hormone on protein phosphorylation in two osteoblast-like cell populations isolated from neonatal mouse calvaria. Calcif Tissue Int 44: 192-199, 1989.
18. Krieger NS, Parker WR, Alexander KM, Bushinsky DA. Prostaglan-dins regulate acid-induced cell-mediated bone resorption. Am J Physiol Renal Physiol 279: F1077-F1082, 2000.
19. Krieger NS, Sessler NE, Bushinsky DA. Acidosis inhibits osteoblastic and stimulates osteoclastic activity in vitro. Am J Physiol Renal Fluid Electrolyte Physiol 262: F442-F448, 1992.
20. Krieger NS, Frick KK, LaPlante Strutz K, Michalenka A, Bushinsky DA. Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro. J Bone Miner Res 22: 907-917, 2007.
21. Lavi-Moshayoff V, Wasserman G, Meir T, Silver J, Naveh-Many T. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am J Physiol Renal Physiol 299: F882-F889, 2010.
22. Lemann J Jr, Bushinsky DA, Hamm LL. Bone buffering of acid and base in humans. Am J Physiol Renal Physiol 285: F811-F832, 2003.
23. Levin A, Bakris GL, Molitch M, Smulders M, Tian J, Williams LA, Andress DL. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int 71: 31-38, 2006.
24. Liu S, Tang W, Zhou J, Stubbs JR, Luo Q, Pi M, Quarles LD. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J Am Soc Nephrol 17: 1305-1315, 2006.
25. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-AACT method. Methods 25: 402-408, 2001.
26. Marsell R, Grundberg E, Krajisnik T, Mallmin H, Karlsson M, Mellstrom D, Orwoll E, Ohlsson C, Jonsson KB, Ljunggren O, Larsson TE. Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men. Eur J Endocrinol 158: 125-129, 2008.
27. Martin A, David V, Quarles LD. Regulation and function of the FGF23/Klotho endocrine pathways. Physiol Rev 92: 131-155, 2012.
28. Moe SM, Radcliffe JS, White KE, Gattone VH, Seifert MF, Chen X, Aldridge B, Chen NX. The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. J Bone Miner Res 26: 2672-2681, 2011.
29. Pande S, Ritter CS, Rothstein M, Wiesen K, Vassiliadis J, Kumar R, Schiavi SC, Slatopolsky E, Brown AJ. FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation. Nephron Physiol 104: 23-32, 2006.
30. Perwad F, Azam N, Zhang MY, Yamashita T, Tenenhouse HS, Portale AA. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology 146: 5358-5364, 2005.
31. Quarles LD. Endocrine functions of bone in mineral metabolism regulation. J Clin Invest 118: 3820-3828, 2008.
32. +-stimulated release of prostaglandin E2 and cyclic adenosine 3',5'-mono-phosphoric acid and their relationship to bone resorption in neonatal mouse calvaria cultures. Bone Miner 11: 295-304, 1990.
33. Razzaque MS. The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis. Nat Rev Endocrinol 5: 611-619, 2009.
34. Rhee Y, Bivi N, Farrow E, Lezcano V, Plotkin LI, White KE, Bellido T. Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone 49: 636-643, 2011.
35. Saji F, Shigematsu T, Sakaguchi T, Ohya M, Orita H, Maeda Y, Ooura M, Mima T, Negi S. Fibroblast growth factor 23 production in bone is directly regulated by 1a,25-dihydroxyvitamin D, but not PTH. Am J Physiol Renal Physiol 299: F1212-F1217, 2010.
36. Stubbs JR, He N, Idiculla A, Gillihan R, Liu S, David V, Hong Y, Quarles LD. Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease. J Bone Miner Res 27: 38-46, 2012.