The CREB-Smad6-Runx2 axis contributes to the impaired osteogenesis potential of bone marrow stromal cells in fibrous dysplasia of bone

Journal of Pathology

Volumn 228, Issue 1, 2012, Pages 45-55

  Fan, Qi Ming ^a   Bing, Yue ^a   Bian, Zhen Yu ^a   Xu, Wen Ting ^a   Bing, Tu ^a   Dai, Ke Rong ^a   Li, Gang ^b   Tang, Ting Ting ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

cAMP; CREB; fibrous dysplasia; GNAS; Runx2; Smad6

Indexed keywords

ADENOVIRUS VECTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; LENTIVIRUS VECTOR; MESSENGER RNA; SMAD6 PROTEIN; TRANSCRIPTION FACTOR RUNX2;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; BONE MARROW STROMAL CELL; CASE REPORT; CELL PROLIFERATION; CONTROLLED STUDY; CREB GENE; DOWN REGULATION; EXPERIMENTAL MODEL; FEMALE; FIBROUS DYSPLASIA; GENE; GENE EXPRESSION; GENE MUTATION; GNAS GENE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; RUNX2 GENE; SIGNAL TRANSDUCTION; SMAD6 GENE; STROMA CELL; UPREGULATION;

ADOLESCENT; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CREB-BINDING PROTEIN; CYCLIC AMP; FEMALE; FIBROUS DYSPLASIA OF BONE; GENETIC VECTORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; LENTIVIRUS; MALE; MESENCHYMAL STROMAL CELLS; MUTATION, MISSENSE; OSTEOGENESIS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD6 PROTEIN; TRANSDUCTION, GENETIC; YOUNG ADULT;

EID: 84864748579     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4033     Document Type: Article

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