P100 deficiency is insufficient for full activation of the alternative NF-κB pathway: TNF cooperates with p52-RelB in target gene transcription

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Lovas, Agnes ^a,d   Weidemann, Anja ^a   Albrecht, Daniela ^b   Wiechert, Lars ^a,e   Weih, Debra ^a   Weih, Falk ^a,c  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b BIOCONTROL JENA GMBH   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOTAXIN; CD34 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 2; PROTEIN; PROTEIN P100; PROTEIN RAD; SERPINA3G; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CHEMOTAXIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FIBROBLAST; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE HOMING; MALIGNANT TRANSFORMATION; MICROARRAY ANALYSIS; MOLECULAR INTERACTION; MOUSE; MOUSE EMBRYO; MOUSE STRAIN; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLEEN; UPREGULATION;

ANIMALS; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MICE; NF-KAPPA B P52 SUBUNIT; PHOSPHORIC DIESTER HYDROLASES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SIGNAL TRANSDUCTION; SPLEEN; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTORS;

EID: 84864722789     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042741     Document Type: Article

References (51)

1. Ghosh S, Karin M, ((2002)) Missing pieces in the NF-kappaB puzzle. Cell 109 (Suppl): S81-96.
2. Hayden MS, Ghosh S, ((2004)) Signaling to NF-kappaB. Genes Dev 18: 2195-2224.
3. Hayden MS, Ghosh S, ((2008)) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
4. Hayden MS, West AP, Ghosh S, ((2006)) NF-kappaB and the immune response. Oncogene 25: 6758-6780.
5. Vallabhapurapu S, Karin M, ((2009)) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27: 693-733.
6. Bours V, Franzoso G, Azarenko V, Park S, Kanno T, et al. ((1993)) The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell 72: 729-739.
7. Fujita T, Nolan GP, Liou HC, Scott ML, Baltimore D, ((1993)) The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev 7: 1354-1363.
8. Hoffmann A, Natoli G, Ghosh G, ((2006)) Transcriptional regulation via the NF-kappaB signaling module. Oncogene 25: 6706-6716.
9. Bonizzi G, Karin M, ((2004)) The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25: 280-288.
10. Dejardin E, ((2006)) The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development. Biochem Pharmacol 72: 1161-1179.
11. Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, et al. ((2002)) The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity 17: 525-535.
12. Derudder E, Dejardin E, Pritchard LL, Green DR, Korner M, et al. ((2003)) RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. J Biol Chem 278: 23278-23284.
13. Müller JR, Siebenlist U, ((2003)) Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways. J Biol Chem 278: 12006-12012.
14. Perkins ND, ((2006)) Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene 25: 6717-6730.
15. Weih F, Caamano J, ((2003)) Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway. Immunol Rev 195: 91-105.
16. Yilmaz ZB, Weih DS, Sivakumar V, Weih F, ((2003)) RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. EMBO J 22: 121-130.
17. Courtois G, Gilmore TD, ((2006)) Mutations in the NF-kappaB signaling pathway: implications for human disease. Oncogene 25: 6831-6843.
18. Rayet B, Gelinas C, ((1999)) Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18: 6938-6947.
19. Xiao G, Rabson AB, Young W, Qing G, Qu Z, ((2006)) Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev 17: 281-293.
20. Ishikawa H, Carrasco D, Claudio E, Ryseck RP, Bravo R, ((1997)) Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2. J Exp Med 186: 999-1014.
21. Guo F, Weih D, Meier E, Weih F, ((2007)) Constitutive alternative NF-kappaB signaling promotes marginal zone B-cell development but disrupts the marginal sinus and induces HEV-like structures in the spleen. Blood 110: 2381-2389.
22. Guo F, Tanzer S, Busslinger M, Weih F, ((2008)) Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis. Blood 112: 551-559.
23. Ciana P, Neri A, Cappellini C, Cavallo F, Pomati M, et al. ((1997)) Constitutive expression of lymphoma-associated NFKB-2/Lyt-10 proteins is tumorigenic in murine fibroblasts. Oncogene 14: 1805-1810.
24. Xiao G, Cvijic ME, Fong A, Harhaj EW, Uhlik MT, et al. ((2001)) Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J 20: 6805-6815.
25. Cogswell PC, Guttridge DC, Funkhouser WK, Baldwin AS Jr, ((2000)) Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3. Oncogene 19: 1123-1131.
26. Nadiminty N, Lou W, Lee SO, Lin X, Trump DL, et al. ((2006)) Stat3 activation of NF-kappaB p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A 103: 7264-7269.
27. Lovas A, Radke D, Albrecht D, Yilmaz ZB, Moller U, et al. ((2008)) Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts. BMC Genomics 9: 606.
28. Schneider K, Potter KG, Ware CF, ((2004)) Lymphotoxin and LIGHT signaling pathways and target genes. Immunol Rev 202: 49-66.
29. Lötzer K, Döpping S, Connert S, Gräbner R, Spanbroek R, et al. ((2009)) Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling. Arterioscler Thromb Vasc Biol 30: 395-402.
30. Ying X, Chan K, Shenoy P, Hill M, Ruddle NH, ((2005)) Lymphotoxin plays a crucial role in the development and function of nasal-associated lymphoid tissue through regulation of chemokines and peripheral node addressin. Am J Pathol 166: 135-146.
31. Kanda H, Newton R, Klein R, Morita Y, Gunn MD, et al. ((2008)) Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat Immunol 9: 415-423.
32. Chen M, O'Connor KL, ((2005)) Integrin alpha 6beta 4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. Oncogene 24: 5125-5130.
33. Corcoran DL, Feingold E, Dominick J, Wright M, Harnaha J, et al. ((2005)) Footer: a quantitative comparative genomics method for efficient recognition of cis-regulatory elements. Genome Res 15: 840-847.
34. McCabe CD, Innis JW, ((2005)) A genomic approach to the identification and characterization of HOXA13 functional binding elements. Nucleic Acids Res 33: 6782-6794.
35. Zapata JM, Krajewska M, Krajewski S, Kitada S, Welsh K, et al. ((2000)) TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. J Immunol 165: 5084-5096.
36. Zhang B, Wang Z, Li T, Tsitsikov EN, Ding HF, ((2007)) NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis. Blood 110: 743-751.
37. Tseng YH, Vicent D, Zhu J, Niu Y, Adeyinka A, et al. ((2001)) Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23. Cancer Res 61: 2071-2079.
38. Lee I, Yeom SY, Lee SJ, Kang WK, Park C, ((2010)) A novel senescence-evasion mechanism involving Grap2 and Cyclin D interacting protein inactivation by Ras associated with diabetes in cancer cells under doxorubicin treatment. Cancer Res 70: 4357-4365.
39. Boutin JA, Ferry G, ((2009)) Autotaxin. Cell Mol Life Sci 66: 3009-3021.
40. Nakanaga K, Hama K, Aoki J, ((2010)) Autotaxin- an LPA producing enzyme with diverse functions. J Biochem 148: 13-24.
41. Yang Y, Mou L, Liu N, Tsao MS, ((1999)) Autotaxin expression in non-small-cell lung cancer. Am J Respir Cell Mol Biol 21: 216-222.
42. Euer N, Schwirzke M, Evtimova V, Burtscher H, Jarsch M, et al. ((2002)) Identification of genes associated with metastasis of mammary carcinoma in metastatic versus non-metastatic cell lines. Anticancer Res 22: 733-740.
43. Yang SY, Lee J, Park CG, Kim S, Hong S, et al. ((2002)) Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clin Exp Metastasis 19: 603-608.
44. Stassar MJ, Devitt G, Brosius M, Rinnab L, Prang J, et al. ((2001)) Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization. Br J Cancer 85: 1372-1382.
45. Wu JM, Xu Y, Skill NJ, Sheng H, Zhao Z, et al. ((2010)) Autotaxin expression and its connection with the TNF-alpha-NF-kappaB axis in human hepatocellular carcinoma. Mol Cancer 9: 71.
46. Kehlen A, Englert N, Seifert A, Klonisch T, Dralle H, et al. ((2004)) Expression, regulation and function of autotaxin in thyroid carcinomas. Int J Cancer 109: 833-838.
47. Kishi Y, Okudaira S, Tanaka M, Hama K, Shida D, et al. ((2006)) Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem 281: 17492-17500.
48. Körner H, Cook M, Riminton DS, Lemckert FA, Hoek RM, et al. ((1997)) Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27: 2600-2609.
49. Schreiber E, Matthias P, Muller MM, Schaffner W, ((1989)) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17: 6419.
50. Weih F, Carrasco D, Bravo R, ((1994)) Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen. Oncogene 9: 3289-3297.
51. Rozen S, Skaletsky H, ((2000)) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132: 365-386.