Novel 1,2,4-thiadiazole derivatives as potent neuroprotectors: Approach to creation of bioavailable drugs

Molecular Pharmaceutics

Volumn 9, Issue 8, 2012, Pages 2156-2167

  Perlovich, German L ^a,b   Proshin, Alexey N ^b   Volkova, Tatyana V ^a   Petrova, Ludmila N ^b   Bachurin, Sergey O ^b  

^a INSTITUTE OF SOLUTION CHEMISTRY   (Russian Federation)

^b INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

Author keywords

1,2,4 thiadiazole derivatives; neuroprotectors; partitioning; permeability; phospholipid membrane; specific activity

Indexed keywords

1 (5 CYCLOPROPYLAMINO 1,2,4 THIADIAZOL 3 YL)PROPAN 2 OL; 1 (5 DIBENZYLAMINO 1,2,4 THIADIAZOL 3 YL)PROPAN 2 OL; 1 [(5 PHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [3 (2 HYDROXYPROPYL) [1,2,4]THIADIAZOL 5 YL] PIPERIDINE 4 CARBOXYLIC ACID AMIDE; 1 [5 (2 CHLORO 5 TRIFLUOROMETHYLPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (2 CHLOROPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (2 FLUOROPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (2 METHYL 3 CHLOROPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (3 CHLORO 4 FLUOROPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (3 CHLORO 4 METHYLPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (3 CHLOROPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (3 METHOXYPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (3 METHYL 4 CHLOROPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (3 METHYLPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (3 METHYLTHIOPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (3,4 DICHLOROPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (4 CHLOROPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (4 ETHOXYPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (4 FLUOROPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (4 METHOXYLPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (4 METHYLPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (4 PYRIDIN 2YLPIPERAZIN 1 YL) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (4 TRIFLUOROMETHYLPHENYLAMINO) 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 (5 METHYLISOXAZOL 3 YLAMINO) [1,2,4]THIADIAZOL 3YL]PROPAN 2 OL; 1 [5 (6 METHYLPYRIDIN 2 YLAMINO) [1,2,4]THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 [4 (1 HYDROXYETHYL)PHENYLAMINO] 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 [4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL] 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1 [5 [4 (4 NITROPHENYL)PIPERAZIN 1 YL] 1,2,4 THIADIAZOL 3 YL]PROPAN 2 OL; 1,2,4 THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; CALCIUM TRANSPORT; DRUG BIOAVAILABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; MEMBRANE PERMEABILITY; NEUROPROTECTION; PARTITION COEFFICIENT; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL AVAILABILITY; CALCIUM; GLUTAMIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPIDS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES; THIADIAZOLES;

EID: 84864687364     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300011r     Document Type: Article

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