Thermodynamic and structural aspects of novel 1,2,4-thiadiazoles in solid and biological mediums

Molecular Pharmaceutics

Volumn 8, Issue 5, 2011, Pages 1807-1820

  Perlovich, German L ^a,b   Proshin, Alexey N ^b   Volkova, Tatyana V ^a   Bui, Cong Trinh ^a   Bachurin, Sergey O ^b  

^a INSTITUTE OF SOLUTION CHEMISTRY   (Russian Federation)

^b INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

Author keywords

1,2,4 thiadiazoles; crystal structure; distribution; salvation; solubility; sublimation thermodynamics; transfer process

Indexed keywords

1 (5 [4 (1 HYDROXY ETHYL)PHENYLAMINO] [1,2,4] THIADIAZOL 3 YL)PROPAN 2 OL; 1 [(5 (4 TRIFLUOROMETHYLPHENYLAMINO) [1,2,4] THIADIAZOL 3 YL] PROPAN 2 OL; 1 [5 (4 FLUORO PHENYLAMINO) [ 1,2,4] THIADIAZOL 3 YL]PROPAN 2 OL; 1,2,4 THIADIAZOLE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; DRUG ACTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; HYDROGEN BOND; PRIORITY JOURNAL; THERMODYNAMICS; VAPOR PRESSURE; X RAY DIFFRACTION;

ALGORITHMS; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CALCIUM CHANNEL BLOCKERS; DRUG DESIGN; GLUTAMIC ACID; MECHANICAL PHENOMENA; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEUROTRANSMITTER UPTAKE INHIBITORS; PHYSICOCHEMICAL PHENOMENA; RATS; SOLUBILITY; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES; THERMODYNAMICS; THIADIAZOLES; WATER;

EID: 80053496769     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2003237     Document Type: Article

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