Prognostic impact of detecting viable circulating tumour cells in gastric cancer patients using a telomerase-specific viral agent: a prospective study

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Ito, Hiroaki ^a   Inoue, Haruhiro ^a   Sando, Norimasa ^a   Kimura, Satoshi ^a   Gohda, Keigo ^b   Sato, Jun ^b   Murakami, Katsuhiro ^b   Ito, Shun ^b   Odaka, Noriko ^a   Satodate, Hitoshi ^a   Kudo, Shin ei ^a  

^a SHOWA UNIVERSITY NORTHERN YOKOHAMA HOSPITAL   (Japan)

^b SYSMEX CORPORATION   (Japan)

Author keywords

Circulating tumour cells; Gastric cancer; Telomerase

Indexed keywords

GREEN FLUORESCENT PROTEIN; ONCOLYTIC ADENOVIRUS; TELOMERASE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BLOOD ANALYSIS; CANCER GROWTH; CANCER INVASION; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CELL COUNT; CELL FUNCTION; CELL INVASION; CELL SIZE; CELL SURVIVAL; CELL VIABILITY; CIRCULATING TUMOR CELL; CONTROLLED STUDY; DISTANT METASTASIS; ENDOSCOPIC BIOPSY; FEMALE; GASTRECTOMY; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LAPAROTOMY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; OVERALL SURVIVAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; STOMACH CANCER; TOTAL STOMACH RESECTION;

ADENOVIRIDAE; ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; FLUORESCENT DYES; GREEN FLUORESCENT PROTEINS; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASTIC CELLS, CIRCULATING; ONCOLYTIC VIRUSES; PROGNOSIS; PROSPECTIVE STUDIES; RECOMBINANT FUSION PROTEINS; ROC CURVE; STOMACH NEOPLASMS; TELOMERASE;

EID: 84864686945     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-346     Document Type: Article

References (40)

1. Kowalski LP. Lymph node metastasis as a prognostic factor in laryngeal cancer. Rev Paul Med 1993, 111(4):42-45.
2. Nakane Y, Okamura S, Masuya Y, Okumura S, Akehira K, Hioki K. Incidence and prognosis of para-aortic lymph node metastasis in gastric cancer. Hepatogastroenterology 1998, 45(23):1901-1906.
3. Arai Y, Kanamaru H, Yoshimura K, Okubo K, Kamoto T, Yoshida O. Incidence of lymph node metastasis and its impact on long-term prognosis in clinically localized prostate cancer. International journal of urology: official journal of the Japanese Urological Association 1998, 5(5):459-465.
4. Liotta LA, Kleinerman J, Saidel GM. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res 1974, 34(5):997-1004.
5. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000, 100(1):57-70. 10.1016/S0092-8674(00)81683-9, 10647931.
6. Vona G, Estepa L, Beroud C, Damotte D, Capron F, Nalpas B, Mineur A, Franco D, Lacour B, Pol S, et al. Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer. Hepatology 2004, 39(3):792-797. 10.1002/hep.20091, 14999698.
7. Vona G, Sabile A, Louha M, Sitruk V, Romana S, Schutze K, Capron F, Franco D, Pazzagli M, Vekemans M, et al. Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulatingtumor cells. Am J Pathol 2000, 156(1):57-63. 10.1016/S0002-9440(10)64706-2, 1868645, 10623654.
8. Talasaz AH, Powell AA, Huber DE, Berbee JG, Roh KH, Yu W, Xiao W, Davis MM, Pease RF, Mindrinos MN, et al. Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device. Proc Natl Acad Sci U S A 2009, 106(10):3970-3975. 10.1073/pnas.0813188106, 2645911, 19234122.
9. He W, Wang H, Hartmann LC, Cheng JX, Low PS. In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry. Proc Natl Acad Sci U S A 2007, 104(28):11760-11765. 10.1073/pnas.0703875104, 1913863, 17601776.
10. Ito H, Kanda T, Nishimaki T, Sato H, Nakagawa S, Hatakeyama K. Detection and quantification of circulating tumor cells in patients with esophageal cancer by real-time polymerase chain reaction. Journal of experimental clinical cancer research: CR 2004, 23(3):455-464.
11. Honma H, Kanda T, Ito H, Wakai T, Nakagawa S, Ohashi M, Koyama Y, Valera VA, Akazawa K, Hatakeyama K. Squamous cell carcinoma-antigen messenger RNA level in peripheral blood predicts recurrence after resection in patients with esophageal squamous cell carcinoma. Surgery 2006, 139(5):678-685. 10.1016/j.surg.2005.09.022, 16701102.
12. Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 2007, 450(7173):1235-1239. 10.1038/nature06385, 3090667, 18097410.
13. Gertler R, Rosenberg R, Fuehrer K, Dahm M, Nekarda H, Siewert JR. Detection of circulating tumor cells in blood using an optimized density gradient centrifugation. Recent Results Cancer Res 2003, 162:149-155. 10.1007/978-3-642-59349-9_13, 12790329.
14. Marth C, Kisic J, Kaern J, Trope C, Fodstad O. Circulating tumor cells in the peripheral blood and bone marrow of patients with ovarian carcinoma do not predict prognosis. Cancer 2002, 94(3):707-712. 10.1002/cncr.10250, 11857303.
15. Silva JM, Rodriguez R, Garcia JM, Munoz C, Silva J, Dominguez G, Provencio M, Espana P, Bonilla F. Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells. Gut 2002, 50(4):530-534. 10.1136/gut.50.4.530, 1773179, 11889075.
16. Hara N, Kasahara T, Kawasaki T, Bilim V, Obara K, Takahashi K, Tomita Y. Reverse transcription-polymerase chain reaction detection of prostate-specific antigen, prostate-specific membrane antigen, and prostate stem cell antigen in one milliliter of peripheral blood: value for the staging of prostate cancer. Clin Cancer Res 2002, 8(6):1794-1799.
17. Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, Picus J, Morse M, Mitchell E, Miller MC, et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26(19):3213-3221. 10.1200/JCO.2007.15.8923, 18591556.
18. Riethdorf S, Fritsche H, Muller V, Rau T, Schindlbeck C, Rack B, Janni W, Coith C, Beck K, Janicke F, et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the Cell Search system. Clin Cancer Res 2007, 13(3):920-928. 10.1158/1078-0432.CCR-06-1695, 17289886.
19. Davis JW, Nakanishi H, Kumar VS, Bhadkamkar VA, McCormack R, Fritsche HA, Handy B, Gornet T, Babaian RJ. Circulating tumor cells in peripheral blood samples from patients with increased serum prostate specific antigen: initial results in early prostate cancer. J Urol 2008, 179(6):2187-2191. discussion 2191, 10.1016/j.juro.2008.01.102, 18423725.
20. Pierga JY, Bidard FC, Mathiot C, Brain E, Delaloge S, Giachetti S, de Cremoux P, Salmon R, Vincent-Salomon A, Marty M. Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a phase II randomized trial. Clin Cancer Res 2008, 14(21):7004-7010. 10.1158/1078-0432.CCR-08-0030, 18980996.
21. Hou JM, Greystoke A, Lancashire L, Cummings J, Ward T, Board R, Amir E, Hughes S, Krebs M, Hughes A, et al. Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy. Am J Pathol 2009, 175(2):808-816. 10.2353/ajpath.2009.090078, 2716975, 19628770.
22. Blackburn EH. Telomere states and cell fates. Nature 2000, 408(6808):53-56. 10.1038/35040500, 11081503.
23. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266(5193):2011-2015. 10.1126/science.7605428, 7605428.
24. Bilsland AE, Merron A, Vassaux G, Keith WN. Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses. Cancer Res 2007, 67(3):1299-1307. 10.1158/0008-5472.CAN-06-3000, 17283167.
25. Fujiwara T, Kagawa S, Kishimoto H, Endo Y, Hioki M, Ikeda Y, Sakai R, Urata Y, Tanaka N. Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy. Int J Cancer 2006, 119(2):432-440. 10.1002/ijc.21846, 16477640.
26. Kojima T, Hashimoto Y, Watanabe Y, Kagawa S, Uno F, Kuroda S, Tazawa H, Kyo S, Mizuguchi H, Urata Y, et al. A simple biological imaging system for detecting viable human circulating tumor cells. J Clin Invest 2009, 119(10):3172-3181. 10.1172/JCI38609, 2752068, 19729837.
27. Kim SJ, Masago A, Tamaki Y, Akazawa K, Tsukamoto F, Sato J, Ozawa T, Tsujino Y, Noguchi S. A novel approach using telomerase-specific replication-selective adenovirus for detection of circulating tumor cells in breast cancer patients. Breast Cancer Res Treat 2011, 128(3):765-773. 10.1007/s10549-011-1603-2, 21630023.
28. Kishimoto H, Kojima T, Watanabe Y, Kagawa S, Fujiwara T, Uno F, Teraishi F, Kyo S, Mizuguchi H, Hashimoto Y, et al. In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus. Nat Med 2006, 12(10):1213-1219. 10.1038/nm1404, 17013385.
29. Lin HK, Zheng S, Williams AJ, Balic M, Groshen S, Scher HI, Fleisher M, Stadler W, Datar RH, Tai YC, et al. Portable filter-based microdevice for detection and characterization of circulating tumor cells. Clin Cancer Res 2010, 16(20):5011-5018. 10.1158/1078-0432.CCR-10-1105, 2955786, 20876796.
30. Zheng S, Lin HK, Lu B, Williams A, Datar R, Cote RJ, Tai YC. 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood. Biomedical microdevices 2011, 13(1):203-213. 10.1007/s10544-010-9485-3, 20978853.
31. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP. Toxicity and response criteria of the Eastern Cooperative Oncology Group. American journal of clinical oncology 1982, 5(6):649-655. 10.1097/00000421-198212000-00014, 7165009.
32. Sobin LH, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumours 2010, Wiley-Blackwell, Oxford, 7.
33. Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. The New England journal of medicine 2004, 351(8):781-791. 10.1056/NEJMoa040766, 15317891.
34. Moreno JG, Miller MC, Gross S, Allard WJ, Gomella LG, Terstappen LW. Circulating tumor cells predict survival in patients with metastatic prostate cancer. Urology 2005, 64(4):713-718.
35. Krebs MG, Sloane R, Priest L, Lancashire L, Hou JM, Greystoke A, Ward TH, Ferraldeschi R, Hughes A, Clack G, et al. Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer. J Clin Oncol 2011, 29(12):1556-1563. 10.1200/JCO.2010.28.7045, 21422424.
36. Katsumata K, Sumi T, Mori Y, Hisada M, Tsuchida A, Aoki T. Detection and evaluation of epithelial cells in the blood of colon cancer patients using RT-PCR. Int J Clin Oncol 2006, 11(5):385-389. 10.1007/s10147-006-0590-5, 17058136.
37. Hiraiwa K, Takeuchi H, Hasegawa H, Saikawa Y, Suda K, Ando T, Kumagai K, Irino T, Yoshikawa T, Matsuda S, et al. Clinical significance of circulating tumor cells in blood from patients with gastrointestinal cancers. Ann Surg Oncol 2008, 15(11):3092-3100. 10.1245/s10434-008-0122-9, 18766405.
38. Tuech JJ, Cervi C, Pessaux P, Villapadierna F, Bergamaschi R, Ronceray J, Arnaud JP. Early gastric cancer: univariate and multivariate analysis for survival. Hepatogastroenterology 1999, 46(30):3276-3280.
39. Bonsing BA, Beerman H, Kuipers-Dijkshoorn N, Fleuren GJ, Cornelisse CJ. High levels of DNA index heterogeneity in advanced breast carcinomas. Evidence for DNA ploidy differences between lymphatic and hematogenous metastases. Cancer 1993, 71(2):382-391. 10.1002/1097-0142(19930115)71:2<382::AID-CNCR2820710219>3.0.CO;2-9, 8422632.
40. Klijanienko J, el-Naggar AK, de Braud F, Rodriguez-Peralto JL, Rodriguez R, Itzhaki M, Russo A, Janot F, Luboinski B, Cvitkovic E. Tumor vascularization, mitotic index, histopathologic grade, and DNA ploidy in the assessment of 114 head and neck squamous cell carcinomas. Cancer 1995, 75(7):1649-1656. 10.1002/1097-0142(19950401)75:7<1649::AID-CNCR2820750715>3.0.CO;2-E, 8826923.