Liver structures of a patient with idiopathic copper toxicosis

Medical Molecular Morphology

Volumn 45, Issue 2, 2012, Pages 105-109

  Hayashi, Hisao ^a   Shinohara, Tsutomu ^b   Goto, Keisuke ^b   Fujita, Yoshikazu ^c   Murakami, Yu ^a   Hattori, Ai ^a   Tatsumi, Yasuaki ^a   Shimizu, Atsumi ^b   Ichiki, Takashi ^a  

^a AICHI GAKUIN UNIVERSITY   (Japan)

^b Kainan Hospital   (Japan)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

ATP7B; Copper; Idiopathic copper toxicosis; Mallory bodies; Metallothionein; Wilson disease

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CERULOPLASMIN; COPPER; HYALURONIC ACID; TRIENTINE; ZINC ACETATE;

ANOREXIA; ARTICLE; ASCITES; ATP7B GENE; CASE REPORT; CELL GRANULE; CELL NUCLEUS; CHELATION THERAPY; CHILD; CHRONIC HEPATITIS; DECOMPENSATED LIVER CIRRHOSIS; DISEASE COURSE; ELECTRON MICROSCOPY; GENE; HUMAN; HUMAN TISSUE; HYPOALBUMINEMIA; IDIOPATHIC COPPER TOXICOSIS; IDIOPATHIC DISEASE; INTOXICATION; JAPANESE; LABORATORY TEST; LEG EDEMA; LIVER CELL; LIVER PARENCHYMA; LIVER TOXICITY; MALE; MALLORY BODY; NEUROIMAGING; PRIORITY JOURNAL; SCHOOL CHILD; SLIT LAMP; TREATMENT RESPONSE; URINE LEVEL; WEIGHT GAIN; WILSON DISEASE;

ASCITES; CHELATING AGENTS; CHILD; COPPER; DIAGNOSIS, DIFFERENTIAL; HEPATOCYTES; HUMANS; LIVER; LIVER DISEASES; MALE; MALLORY BODIES; TREATMENT OUTCOME; TRIENTINE;

EID: 84864650852     PISSN: 18601480     EISSN: 18601499     Source Type: Journal    
DOI: 10.1007/s00795-011-0556-1     Document Type: Article

References (14)

1. Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B, Romano MD, Parano E, Pavone L, Brzustowicz LM, Devoto M, Peppercorn J, Bush AI, Sternlieb I, Pirastu M, Gusella JF, Evgrafov O, Penchaszadeh GK, Honig B, Edelman IS, Soares MB, Scheinberg IH, Gilliam TC (1993) The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat Genet 5:344-350 (Pubitemid 23351304)
2. Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW (1993) The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat Genet 5:327-337 (Pubitemid 23351302)
3. Yamaguchi Y, Heiny ME, Gitlin JD (1993) Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease. Biochem Biophys Res Commun 197:271-277 (Pubitemid 23358907)
4. Coronado VA, Bonneville JA, Nazer H, Roberts EA, Cox, DW (2005) COMMD1 (MURR1) as a candidate in patients with copper storage disease of undefined etiology. Clin Genet 68:548-551 (Pubitemid 41748855)
5. Scheinberg IH, Sternlieb I (1994) Is non-Indian childhood cirrhosis caused by dietary copper? Lancet 344:1002-1004 (Pubitemid 24306559)
6. Muller T, Muller W, Feichtinger H (1998) Idiopathic copper toxicosis. Am J Clin Nutr 67(suppl):1082S-1086S (Pubitemid 28198837)
7. Ferenci P, Caca K, Loudianos G, Mieli-Vergani G, Tanner S, Sternlieb I, Schilsky M, Cox D, Berr F (2003) Diagnosis and phenotypic classification of Wilson disease. Liver Int 23:139-142 (Pubitemid 37265785)
8. Nagasaka H, Kobayashi K, Yorifuji T, Kage M, Kimura A, Takayanagi M, Kikuta H, Egawa H, Tanaka K, Inui A, Fujisawa T, Ohtake A (1999) Indian childhood cirrhosis-like disease in a Japanese boy undergoing liver transplantation. J Pediatr Gastroenterol Nutr 29:598-600 (Pubitemid 30346346)
9. Tatsumi Y, Hattori A, Hayashi H, Ikoma J, Kaito M, Imoto M, Wakusawa S, Yano M, Hayashi K, Katano Y, Goto H, Okada T, Kaneko S (2010) Current state of Wilson disease patients in central Japan. Intern Med 49:809-815
10. Motonishi S, Hayashi H, Fujita Y, Okada T, Kusakabe A, Ito M, Miyamoto K, Ueno T (2006) Copper-and iron-rich matrices in hepatocellular lipofuscin particles of a young male patient: diagnostic ultrastructures for Wilson disease. Ultrastruct Pathol 30:409-414 (Pubitemid 46018567)
11. Kumagi T, Horiike N, Michitaka K, Hasebe A, Kawai K, Tokumoto Y, Nakanishi S, Furukawa S, Hiasa Y, Matsui H, Kurose K, Matsuura B, Onji M (2004) Recent clinical features of Wilson's disease with hepatic presentation. J Gastroenterol 39:1165-1169 (Pubitemid 40074282)
12. Stromeyer FW, Ishak KG (1980) Histology of the liver in Wilson's disease. Am J Clin Pathol 73:2-24
13. Shiono Y, Wakusawa S, Hayashi H, Takikawa T, Yano M, Okada T, Mabuchi H, Kono S, Miyajima H (2001) Iron accumulation in the liver of male patients with Wilson's disease. Am J Gastroenterol 96:3147-3151 (Pubitemid 33095355)
14. Miyajima H, Nishimura Y, Mizoguchi K, Sakamoto M, Shimizu T, Honda N (1987) Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degeneration. Neurology 37:761-76