Cubilin is expressed in rat and human glomerular podocytes

Nephrology Dialysis Transplantation

Volumn 27, Issue 8, 2012, Pages 3156-3159

  Prabakaran, Thaneas ^a   Christensen, Erik Ilso ^a   Nielsen, Rikke ^a   Verroust, Pierre J ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b INSTITUT DE LA VISION   (France)

Author keywords

albumin; cubilin; endocytosis; megalin; podocytes

Indexed keywords

ALBUMIN; AMINOPEPTIDASE; CELL SURFACE PROTEIN; CUBILIN; MEGALIN; MESSENGER RNA; NEPHRIN; PODOCIN;

AMINOPEPTIDASE GENE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; CUBILIN GENE; ENDOCYTOSIS; GENE; GENE EXPRESSION REGULATION; GENE TARGETING; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS EPITHELIUM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; INTRACELLULAR SIGNALING; KIDNEY TUBULE ABSORPTION; LYSOSOME MEMBRANE; MALE; MEGALIN GENE; NEPHRIN GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PODOCIN GENE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BASE SEQUENCE; CELL LINE; CELL MEMBRANE; DNA PRIMERS; ENDOCYTOSIS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, FLUORESCENCE; MICROSCOPY, IMMUNOELECTRON; PODOCYTES; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84864634075     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr794     Document Type: Article

References (21)

1. Mundel P, Reiser J. Proteinuria: an enzymatic disease of the podocyte? Kidney Int 2010; 77: 571-580.
2. Farquhar MG, Wissig SL, Palade GE. Glomerular permeability. I. Ferritin transfer across the normal glomerular capillary wall. J Exp Med 1961; 113: 47-66.
3. Farquhar MG, Palade GE. Glomerular permeability. II. Ferritin transfer across the glomerular capillary wall in nephrotic rats. J Exp Med 1961; 114: 699-716.
4. Eyre J, Ioannou K, Grubb BD et al. Statin-sensitive endocytosis of albumin by glomerular podocytes. Am J Physiol Renal Physiol 2007; 292: F674-F681.
5. Christensen EI, Verroust PJ, Nielsen R. Receptor-mediated endocytosis in renal proximal tubule. Pflugers Arch 2009; 458: 1039-1048.
6. Cui S, Verroust PJ, Moestrup SK et al. Megalin/gp330 mediates uptake of albumin in renal proximal tubule. Am J Physiol 1996; 271: F900-F907.
7. Birn H, Fyfe JC, Jacobsen C et al. Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest 2000; 105: 1353-1361.
8. Zhai XY, Nielsen R, Birn H et al. Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney. Kidney Int 2000; 58: 1523-1533.
9. Amsellem S, Gburek J, Hamard G et al. Cubilin is essential for albumin reabsorption in the renal proximal tubule. J Am Soc Nephrol 2010; 21: 1859-1867.
10. Kerjaschki D, Farquhar MG. Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 1983; 157: 667-686.
11. Kerjaschki D, Horvat R, Binder S et al. Identification of a 400-kd protein in the brush border of human kidney tubules that is similar to gp330, the nephritogenic antigen of rat Heymann nephritis. Am J Pathol 1987; 129: 183-191.
12. Prabakaran T, Nielsen R, Larsen JV et al. Receptor-mediated endocytosis of alpha-galactosidase A in human podocytes in Fabry disease. PLoS One 2011; 6: e25065.
13. Sahali D, Mulliez N, Chatelet F et al. Comparative immunochemistry and ontogeny of two closely related coated pit proteins. The 280-kd target of teratogenic antibodies and the 330-kd target of nephritogenic antibodies. Am J Pathol 1993; 142: 1654-1667.
14. Christensen EI, Zhou Q, Sorensen SS et al. Distribution of alphagalactosidase A in normal human kidney and renal accumulation and distribution of recombinant alpha-galactosidase A in Fabry mice. J Am Soc Nephrol 2007; 18: 698-706.
15. Saleem MA, O'Hare MJ, Reiser J et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 2002; 13: 630-638.
16. Kugler P, Wolf G, Scherberich J. Histochemical demonstration of peptidases in the human kidney. Histochemistry 1985; 83: 337-341.
17. Tanji N, Ross MD, Cara A et al. Effect of tissue processing on the ability to recover nucleic acid from specific renal tissue compartments by laser capture microdissection. Exp Nephrol 2001; 9: 229-234.
18. Odera K, Goto S, Takahashi R. Age-related change of endocytic receptors megalin and cubilin in the kidney in rats. Biogerontology 2007; 8: 505-515.
19. Yoshikawa N, Ito H, Akamatsu R et al. Glomerular podocyte vacuolation in focal segmental glomerulosclerosis. Arch Pathol Lab Med 1986; 110: 394-398.
20. Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage? J Am Soc Nephrol 2006; 17: 2974-2984.
21. Morigi M, Buelli S, Angioletti S et al. In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies. Am J Pathol 2005; 166: 1309-1320