Antimicrobial stewardship in pediatric care: Strategies and future directions

Pharmacotherapy

Volumn 32, Issue 8, 2012, Pages 735-743

  Newland, Jason G ^a,g   Banerjee, Ritu ^b   Gerber, Jeffrey S ^c   Hersh, Adam L ^d   Steinke, Leah ^e   Weissman, Scott J ^f  

^a UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^b Mayo Clinic   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^f UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^g CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

Antibiograms; Antimicrobial stewardship; Pediatrics; Prior authorization; Prospective audit with feedback; Special populations

Indexed keywords

ANTIMICROBIAL STEWARDSHIP; CHILD HEALTH CARE; DRUG USE; HEALTH CARE; HEALTH CARE PERSONNEL; HEALTH CARE QUALITY; HEALTH PROGRAM; HUMAN; INFORMATION TECHNOLOGY; MEDICAL RESEARCH; PATIENT CARE; PRACTICE GUIDELINE; PROGRAM DEVELOPMENT; RESEARCH PRIORITY; REVIEW; STRATEGIC PLANNING;

ANTI-INFECTIVE AGENTS; CHILD; DRUG DESIGN; DRUG RESISTANCE, MICROBIAL; ENDPOINT DETERMINATION; HOSPITALS; HUMANS; INFECTION; PHYSICIAN'S PRACTICE PATTERNS; PRACTICE GUIDELINES AS TOPIC; QUALITY OF HEALTH CARE; RESEARCH DESIGN;

EID: 84864629098     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1875-9114.2012.01155.x     Document Type: Review

References (61)

1. Bartlett JG. A call to arms: The imperative for antimicrobial stewardship. Clin Infect Dis 2011;53(Suppl 1):S4-7.
2. Policy and Medicine. Generating Antibiotic Incentives Now (GAIN) Act, November 2011. Available at http://www.policymed. com/2011/10/generating- antibiotic-incentives-now-gainact. html. Accessed June 18, 2012.
3. Grohskopf LA, Huskins WC, Sinkowitz-Cochran RL, Levine GL, Goldmann DA, Jarvis WR. Use of antimicrobial agents in United States neonatal and pediatric intensive care patients. Pediatr Infect Dis J 2005;24:766-73.
4. Gerber JS, Newland JG, Coffin SE, et al. Variability in antibiotic use at Children's Hospitals. Pediatrics 2010;126:1067-73.
5. Pakyz AL, Gurgle HE, Ibrahim OM, Oinonen MJ, Polk RE. Trends in antibacterial use in hospitalized pediatric patients in United States academic health centers. Infect Control Hosp Epidemiol 2009;30:600-3.
6. Hersh AL, Shapiro DJ, Newland JG, Polgreen PM, Beekmann SE, Shah SS. Variability in pediatric infectious disease consultants' recommendations for management of communityacquired pneumonia. PLoS ONE 2011;6:e20325.
7. Dellit TH, Owens RC, McGowan JE Jr, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 2007;44:159-77.
8. Gross R, Morgan AS, Kinky DE, Weiner M, Gibson GA, Fishman NO. Impact of a hospital-based antimicrobial management program on clinical and economic outcomes. Clin Infect Dis 2001;33:289-95.
9. Di Pentima MC, Chan S, Hossain J. Benefits of a pediatric antimicrobial stewardship program at a Children's Hospital. Pediatrics 2011;128:1062-70.
10. Metjian TA, Prasad PA, Kogon A, Coffin SE, Zaoutis TE. Evaluation of an antimicrobial stewardship program at a pediatric teaching hospital. Pediatr Infect Dis J 2008;27:106-11.
11. Newland JG, Stach LM, De Lurgio SA, et al. Impact of a prospective-audit-with-feedback antimicrobial stewardship program at a Children's Hospital. J of Pediatric Infectious Diseases Soc 2012;in press.
12. Agwu AL, Lee CK, Jain SK, et al. A World Wide Web-based antimicrobial stewardship program improves efficiency, communication, and user satisfaction and reduces cost in a tertiary care pediatric medical center. Clin Infect Dis 2008;47:747-53.
13. Mullett CJ, Evans RS, Christenson JC, Dean JM. Development and impact of a computerized pediatric antiinfective decision support program. Pediatrics 2001;108:E75.
14. Hindler JF, Stelling J. Analysis and presentation of cumulative antibiograms: A new consensus guideline from the Clinical and Laboratory Standards Institute. Clin Infect Dis 2007;44:867-73.
15. Fridkin SK, Edwards JR, Tenover FC, Gaynes RP, McGowan JE Jr. Antimicrobial resistance prevalence rates in hospital antibiograms reflect prevalence rates among pathogens associated with hospital-acquired infections. Clin Infect Dis 2001;33:324-30.
16. Fridkin SK, Steward CD, Edwards JR, et al. Surveillance of antimicrobial use and antimicrobial resistance in United States hospitals: Project ICARE phase 2. Project Intensive Care Antimicrobial Resistance Epidemiology (ICARE) hospitals. Clin Infect Dis 1999;29:245-52.
17. Bosso JA, Mauldin PD, Steed LL. Consequences of combining cystic fibrosis- and non-cystic fibrosis-derived Pseudomonas aeruginosa antibiotic susceptibility results in hospital antibiograms. Ann Pharmacother 2006;40:1946-9.
18. Mermel LA, Jefferson J, Devolve J. Knowledge and use of cumulative antimicrobial susceptibility data at a university teaching hospital. Clin Infect Dis 2008;46:1789.
19. Conterno LO, Shymanski J, Ramotar K, Toye B, Zvonar R, Roth V. Impact and cost of infection control measures to reduce nosocomial transmission of extended-spectrum betalactamase- producing organisms in a non-outbreak setting. J Hosp Infect 2007;65:354-60.
20. Di Pentima MC, Chan S. Impact of antimicrobial stewardship program on vancomycin use in a pediatric teaching hospital. Pediatr Infect Dis J 2010;29:707-11.
21. Patel SJ, Larson EL, Kubin CJ, Saiman L. A review of antimicrobial control strategies in hospitalized and ambulatory pediatric populations. Pediatr Infect Dis J 2007;26:531-7.
22. Newman RE, Hedican EB, Herigon JC, Williams DD, Williams AR, Newland JG. Impact of a clinical practice guideline on management of children hospitalized with community acquired pneumonia. Pediatrics 2012;129:e597-604.
23. Bolon MK, Arnold AD, Feldman HA, Goldmann DA, Wright SB. An antibiotic order form intervention does not improve or reduce vancomycin use. Pediatr Infect Dis J 2005;24:1053-8.
24. Echols RM, Kowalsky SF. The use of an antibiotic order form for antibiotic utilization review: Influence on physicians' prescribing patterns. J Infect Dis 1984;150:803-7.
25. Levy I, Leibovici L, Drucker M, Samra Z, Konisberger H, Ashkenazi S. A prospective study of Gram-negative bacteremia in children. Pediatr Infect Dis J 1996;15:117-22.
26. Zaoutis T, Localio AR, Leckerman K, Saddlemire S, Bertoch D, Keren R. Prolonged intravenous therapy versus early transition to oral antimicrobial therapy for acute osteomyelitis in children. Pediatrics 2009;123:636-42.
27. Winters BD, Thiemann DR, Brotman DJ. Impact of a restrictive antimicrobial policy on the process and timing of antimicrobial administration. J Hosp Med 2010;5:E41-5.
28. Patel SJ, Oshodi A, Prasad P, et al. Antibiotic use in neonatal intensive care units and adherence with Centers for Disease Control and Prevention 12 Step Campaign to Prevent Antimicrobial Resistance. Pediatr Infect Dis J 2009;28:1047-51.
29. Martinez JA, Cobos-Trigueros N, Soriano A, et al. Influence of empiric therapy with a beta-lactam alone or combined with an aminoglycoside on prognosis of bacteremia due to gramnegative microorganisms. Antimicrob Agents Chemother 2010;54:3590-6.
30. Martin CA, Armitstead JA, Mynatt RP, Hoven AD. Moving antimicrobial stewardship from restriction to facilitation. Am J Health Syst Pharm 2011;68:109-10.
31. Hersh AL, Beekmann SE, Polgreen PM, Zaoutis TE, Newland JG. Antimicrobial stewardship programs in pediatrics. Infect Control Hosp Epidemiol 2009;30:1211-7.
32. Di Pentima MC, Chan S, Eppes SC, Klein JD. Antimicrobial prescription errors in hospitalized children: Role of antimicrobial stewardship program in detection and intervention. Clin Pediatr (Phila) 2009;48:505-12.
33. Stevens V, Dumyati G, Fine LS, Fisher SG, van Wijngaarden E. Cumulative antibiotic exposures over time and the risk of Clostridium difficile infection. Clin Infect Dis 2011;53:42-8.
34. Levy ER, Swami S, Dubois SG, Wendt R, Banerjee R. Rates and appropriateness of antimicrobial prescribing at an academic children's hospital, 2007-2010. Infect Control Hosp Epidemiol 2012;33:346-53.
35. Gentry CA, Greenfield RA, Slater LN, Wack M, Huycke MM. Outcomes of an antimicrobial control program in a teaching hospital. Am J Health Syst Pharm 2000;57:268-74.
36. Organization WH. WHO Collaborating Centre for Drug Statistics Methodology. Available from http://www.whocc.no/ddd/definition-and-general- considera/. Accessed January 31, 2012.
37. Polk RE, Fox C, Mahoney A, Letcavage J, MacDougall C. Measurement of adult antibacterial drug use in 130 US hospitals: Comparison of defined daily dose and days of therapy. Clin Infect Dis 2007;44:664-70.
38. Polk RE, Hohmann SF, Medvedev S, Ibrahim O. Benchmarking risk-adjusted adult antibacterial drug use in 70 US Academic Medical Center Hospitals. Clin Infect Dis 2011;53: 1100-1110.
39. Standiford HC, Chan S, Tripoli M, Weekes E, Forrest GN. Antimicrobial stewardship at a large tertiary care academic medical center: Cost analysis before, during, and after a 7-year program. Infect Control Hosp Epidemiol 2012;33:338-45.
40. Stevenson KB, Balada-Llasat JM, Bauer K, et al. The economics of antimicrobial stewardship: The current state of the art and applying the business case model. Infect Control Hosp Epidemiol 2012;33:389-97.
41. Perencevich EN, Stone PW, Wright SB, et al. Raising standards while watching the bottom line: Making a business case for infection control. Infect Control Hosp Epidemiol 2007; 28:1121-33.
42. Kim J, Shaklee JF, Smathers S, et al. Risk factors and outcomes associated with severe Clostridium difficile infection in children. Pediatr Infect Dis J 2012;31:134-8.
43. Talpaert MJ, Gopal Rao G, Cooper BS, Wade P. Impact of guidelines and enhanced antibiotic stewardship on reducing broad-spectrum antibiotic usage and its effect on incidence of Clostridium difficile infection. J Antimicrob Chemother 2011;66:2168-74.
44. Stach LM, Hedican EB, Herigon JC, Newland JG. Attitudes towards a prospective-audit-with-feedback antimicrobial stewardship program at a children's hospital. J of Pediatric Infectious Diseases Soc 2012;in press.
45. Herigon JC, Hersh AL, Gerber JS, Zaoutis TE, Newland JG. Antibiotic management of Staphylococcus aureus infections in US children's hospitals, 1999-2008. Pediatrics 2010;125: E1294-300.
46. Liem TB, Krediet TG, Fleer A, Egberts TC, Rademaker CM. Variation in antibiotic use in neonatal intensive care units in the Netherlands. J Antimicrob Chemother 2010;65:1270-5.
47. Patel S, Landers T, Larson E, et al. Clinical vignettes provide an understanding of antibiotic prescribing practices in neonatal intensive care units. Infect Control Hosp Epidemiol 2011;32:597-602.
48. Hersh AL, Shapiro DJ, Pavia AT, Shah SS. Antibiotic prescribing in ambulatory pediatrics in the United States. Pediatrics 2011;128:1053-61.
49. Nash DR, Harman J, Wald ER, Kelleher KJ. Antibiotic prescribing by primary care physicians for children with upper respiratory tract infections. Arch Pediatr Adolesc Med 2002;156:1114-9.
50. Nyquist AC, Gonzales R, Steiner JF, Sande MA. Antibiotic prescribing for children with colds, upper respiratory tract infections, and bronchitis. JAMA 1998;279:875-7.
51. Kaki R, Elligsen M, Walker S, Simor A, Palmay L, Daneman N. Impact of antimicrobial stewardship in critical care: A systematic review. J Antimicrob Chemother 2011;66: 1223-30.
52. Byington CL, Castillo H, Gerber K, et al. The effect of rapid respiratory viral diagnostic testing on antibiotic use in a children's hospital. Arch Pediatr Adolesc Med 2002;156:1230-4.
53. Wishaupt JO, Russcher A, Smeets LC, Versteegh FG, Hartwig NG. Clinical impact of RT-PCR for pediatric acute respiratory infections: A controlled clinical trial. Pediatrics 2011;128:e1113-20.
54. Agarwal R, Schwartz DN. Procalcitonin to guide duration of antimicrobial therapy in intensive care units: A systematic review. Clin Infect Dis 2011;53:379-87.
55. Copp HL, Shapiro DJ, Hersh AL. National ambulatory antibiotic prescribing patterns for pediatric urinary tract infection, 1998-2007. Pediatrics 2011;127:1027-33.
56. Paul IM, Maselli JH, Hersh AL, Boushey HA, Nielson DW, Cabana MD. Antibiotic prescribing during pediatric ambulatory care visits for asthma. Pediatrics 2011;127:1014-21.
57. Shapiro DJ, Gonzales R, Cabana MD, Hersh AL. National trends in visit rates and antibiotic prescribing for children with acute sinusitis. Pediatrics 2011;127:28-34.
58. Finkelstein JA, Huang SS, Kleinman K, et al. Impact of a 16- community trial to promote judicious antibiotic use in Massachusetts. Pediatrics 2008;121:e15-23.
59. Jamtvedt G, Young JM, Kristoffersen DT, O'Brien MA, Oxman AD. Audit and feedback: Effects on professional practice and health care outcomes. Cochrane Database Syst Rev 2006;2:CD000259.
60. Kiefe CI, Allison JJ, Williams OD, Person SD, Weaver MT, Weissman NW. Improving quality improvement using achievable benchmarks for physician feedback: A randomized controlled trial. JAMA 2001;285:2871-9.
61. Heintz BH, Halilovic J, Christensen CL. Impact of a multidisciplinary team review of potential outpatient parenteral antimicrobial therapy prior to discharge from an academic medical center. Ann Pharmacother 2011;45:1329-37.