Modular design of artificial tissue homeostasis: Robust control through synthetic cellular heterogeneity

PLoS Computational Biology

Volumn 8, Issue 7, 2012, Pages

  Miller, Miles ^a   Hafner, Marc ^a,b,c,d,h   Sontag, Eduardo ^e   Davidsohn, Noah ^a   Subramanian, Sairam ^f   Purnick, Priscilla E M ^g   Lauffenburger, Douglas ^a   Weiss, Ron ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b EPFL   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^e RUTGERS UNIVERSITY   (United States)

^f Princeton University   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAYESIAN NETWORKS; GENES; ITERATIVE METHODS; PHYSIOLOGY; RATE CONSTANTS; SENSITIVITY ANALYSIS; STEM CELLS; TISSUE;

ARTIFICIAL TISSUES; CELLULARS; DESIGN SYSTEMS; GENE NETWORKS; HOMOEOSTASIS; LARGE-SCALES; MODULAR DESIGNS; SYNTHETIC BIOLOGY; SYNTHETIC GENE CIRCUITS; SYSTEM INTEGRATION;

ROBUST CONTROL;

ARTICLE; ARTIFICIAL CELL; CELL DEATH; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CELL SYNCHRONIZATION; EMBRYO; GENETIC ENGINEERING; GENETIC VARIABILITY; HOMEOSTASIS; HUMAN; HUMAN CELL; SENSITIVITY ANALYSIS; STEM CELL; SYSTEM ANALYSIS; THEORETICAL MODEL; TISSUE ENGINEERING;

EID: 84864613352     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002579     Document Type: Article

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