Fabrication of porous PLGA microspheres with BMP-2 releasing polyphosphate-functionalized nano-hydroxyapatite for enhanced bone regeneration

Macromolecular Research

Volumn 20, Issue 7, 2012, Pages 715-724

  Jeon, Byeong Jin ^a   Jeong, Seo Young ^a   Koo, Ahn Na ^a   Kim, Byung Chul ^a   Hwang, Yu Shik ^a   Lee, Sang Cheon ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Bone morphogenetic protein 2; Microsphere; Nano hydroxyapatite; Polyphosphate; Surface immobilization

Indexed keywords

3-D CELL CULTURE; ADIPOSE DERIVED STEM CELLS; BONE MORPHOGENETIC PROTEIN-2; BONE REGENERATION; BONE TISSUE; BONE TISSUE FORMATION; CHEMICAL IMMOBILIZATION; DOUBLE EMULSIONS; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; GAS-FORMING; INTERCONNECTED PORES; INTRINSIC ACTIVITIES; NANO-HYDROXYAPATITE; OSTEOCONDUCTION; OSTEOGENIC DIFFERENTIATION; OSTEOINDUCTIVE PROPERTIES; PLGA MICROSPHERES; POLY-LACTIDE-CO-GLYCOLIDE; POLYPHOSPHATES; PORE SURFACE; POROUS MICROSPHERES; POROUS PLGA MICROSPHERE; POROUS POLYMERS; POSITIVE CHARGES; QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION; RELEASE RATE; SOLVENT EVAPORATION; SURFACE IMMOBILIZATION; SUSTAINED RELEASE; WATER-IN-OIL-IN-WATER;

BONE; CELL CULTURE; EMULSIFICATION; ENAMELS; NANOCOMPOSITES; PHOTOELECTRONS; POLYMERASE CHAIN REACTION; SCAFFOLDS (BIOLOGY); STEM CELLS; TISSUE; X RAY PHOTOELECTRON SPECTROSCOPY;

MICROSPHERES;

EID: 84864589035     PISSN: 15985032     EISSN: 20927673     Source Type: Journal    
DOI: 10.1007/s13233-012-0103-5     Document Type: Article

References (32)

1. Y. Liu, Y. Lu, X. Tian, G. Cui, Y. Zhao, Q. Yang, S. Yu, G. Xing, and B. Zhang, Biomaterials, 30, 6276 (2009).
2. S. S. Kim, S. J. Gwak, and B. S. Kim, J. Biomed. Mater. Res., 87A, 245 (2008).
3. K. Kim, D. Dean, A. Lu, A. G. Mikos, and J. P. Fisher, Acta Biomater., 7, 1249 (2011).
4. H. Shen, X. Hu, F. Yang, J. Bei, and S. Wang, Acta Biomater., 6, 455 (2010).
5. G. Wei and P. X. Ma, Biomaterials, 25, 4749 (2004).
6. N. Ribeiro, S. R. Sousa, and F. J. Monteiro, J. Colloid Interface Sci., 351, 398 (2010).
7. S. S. Kim, M. S. Park, O. Jeon, C. Y. Choi, and B. S. Kim, Biomaterials, 27, 1399 (2006).
8. C. R. Kothapalli, M. T. Shaw, and M. Wei, Acta Biomater., 1, 653 (2005).
9. T. Kokubo, Acta Mater., 46, 2519 (1998).
10. W. J. Landis, F. H. Silver, and J. W. Freeman, J. Mater. Chem., 16, 1495 (2006).
11. J. Lee, W. I. Choi, G. Tae, Y. H. Kim, S. S. Kang, S. E. Kim, S. H. Kim, Y. Jung, and S. H. Kim, Acta Biomater., 7, 244 (2011).
12. C. Li, C. Vepari, H. J. Jin, H. J. Kim, and D. L. Kaplan, Biomaterials, 27, 3115 (2006).
13. I. Song, B. S. Kim, C. S. Kim, and G. I. Im, Biochem. Biophys. Res. Commun., 408, 126 (2011).
14. S. C. Lee, H. W. Choi, H. J. Lee, K. J. Kim, J. H. Chang, S. Y. Kim, J. Choi, K. S. Oh, and Y. K. Jeong, J. Mater. Chem., 17, 174 (2007).
15. H. J. Chung, I. K. Kim, T. G. Kim, and T. G. Park, Tissue Eng. Part A, 14, 607 (2008).
16. K. Park, J. S. Park, D. G. Woo, H. N. Yang, H. M. Chung, and K. H. Park, Biomaterials, 29, 2490 (2008).
17. S. E. Kim, H. W. Choi, H. J. Lee, J. H. Chang, J. Choi, K. J. Kim, H. J. Lim, Y. J. Jun, and C. Lee, J. Mater. Chem., 18, 4994 (2008).
18. H. J. Lee, H. W. Choi, K. J. Kim, and S. C. Lee, Chem. Mater., 18, 5111 (2006).
19. G. Ciapetti, L. Ambrosio, L. Savarino, D. Granchi, E. Cenni, N. Baldini, S. Pagani, S. Guizzardi, F. Causa, and A. Giunti, Biomaterials, 24, 3815 (2003).
20. H. W. Choi, H. J. Lee, K. J. Kim, H. M. Kim, and S. C. Lee, J. Colloid Interface Sci., 304, 277 (2006).
21. F. M. Chen, R. Chen, X. J. Wang, H. H. Sun, and Z. F. Wu, Biomaterials, 30, 5215 (2009).
22. Y. Liu, Y. Lu, X. Tian, G. Cui, Y. Zhao, Q. Yang, S. Yu, G. Xing, and B. Zhang, Biomaterials, 30, 6276 (2009).
23. H. J. Chung and T. G. Park, Tissue Eng. Part A, 15, 1391 (2008).
24. Z. Shi, K. G. Neoh, E. T. Kang, C. K. Poh, and W. Wang, Biomacromolecules, 10, 1603 (2009).
25. G. Balasundaram, C. Yao, and T. J. Webster, J. Biomed. Mater. Res., 84A, 447 (2008).
26. J. D. Kretlow and A. G. Mikos, Tissue Eng., 13, 927 (2007).
27. I. C. Stancu, R. Filmon, C. Cincu, B. Marculescu, C. Zaharia, Y. Tourmen, M. F. Basle, and D. Chappard, Biomaterials, 25, 205 (2004).
28. Y. J. Yin, X. Y. Luo, J. F. Cui, C. Y. Wang, X. M. Guo, and K. D. Yao, Macromol. Biosci., 4, 971 (2004).
29. W. L. Murphy and D. J. Mooney, J. Am. Chem. Soc., 124, 1910 (2002).
30. J. Tan, R. A. Gemeinhart, M. Ma, and W. M. Saltzman, Biomaterials, 26, 3663 (2005).
31. R. A. Gemeinhart, C. M. Bare, R. T. Haasch, and E. J. Gemeinhart, J. Biomed. Mater. Res. A, 78, 433 (2006).
32. J. Jadlowiec, H. Koch, X. Zhang, P. G. Campbell, M. Seyedain, and C. Sfeir, J. Biol. Chem., 279, 53323 (2004).