Association of Caucasian-identified variants with colorectal cancer risk in Singapore Chinese

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Thean, Lai Fun ^a   Li, Hui Hua ^a   Teo, Yik Ying ^b   Koh, Woon Puay ^b   Yuan, Jian Min ^c   Teoh, Mei Lin ^a   Koh, Poh Koon ^a   Tang, Choong Leong ^a   Cheah, Peh Yean ^a,b,d  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; BMP2 GENE; BMP4 GENE; CANCER RISK; CHINESE; CHROMOSOME 10P; CHROMOSOME 11Q; CHROMOSOME 18Q; CHROMOSOME 8Q; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GREM1 GENE; HUMAN; HUMAN TISSUE; LAMA 5 GENE; MAJOR CLINICAL STUDY; MALE; SEX DIFFERENCE; SINGAPORE; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SINGAPORE;

EID: 84864564885     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042407     Document Type: Article

References (28)

1. Houlston RS, Cheadle J, Dobbins SE, Tenesa A, Jones AM, et al. ((2010)) Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. Nat Genet 42: 973-977.
2. Carvajal-Carmona LG, Cazier J, Jones AM, Howarth K, Broderick P, et al. ((2011)) Fine-mapping of colorectal cancer susceptibililty loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes. Hum Molec Genet 20: 2879-2888.
3. Tomlinson IPM, Carvajal-Carmona LG, Dobbins SE, Tenesa A, Jones AM, et al. ((2011)) Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. PLoS Genet 7: e1002105.
4. Kupfer SS, Anderson JR, Hooker S, Skol A, Kittles RA, et al. ((2010)) Genetic heterogeneity in colorectal cancer associations between African and European Americans. Gastroenterology 139: 1677-1685.
5. Xiong F, Wu C, Bi X, Yu D, Huang L, et al. ((2010)) Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population. Cancer Epidemiol Biomarkers Prev 19: 1855-1861.
6. Ho JW, Choi SC, Lee YF, Cherny SS, Garcia-Barcelo MM, et al. ((2011)) Replication study of SNP associations for colorectal cancer in Hong Kong Chinese. Br J Cancer 104: 369-375.
7. Xu S, Yin X, Li S, Jin W, Lou H, et al. ((2009)) Genomic dissection of population substructure of Han Chinese and its implication in association studies. Am J Hum Genet 85: 1-13.
8. Chen J, Zheng H, Bei J, Sun L, Jia W, et al. ((2009)) Genetic Structure of the Han Chinese Population revealed by genome-wide SNP variation. Am J Hum Genet 85: 775-785.
9. Chia KS, Seow A, Lee HP, Shanmugaratnam K, ((2000)) Singapore Cancer Registry Report No. pp. 5.
10. Hankin JH, Stram DO, Arakawa K, Park S, Low SH, et al. ((2001)) Singapore Chinese Health Study: development, validation, and calibration of the quantitative food frequency questionnaire. Nutr Cancer 39: 187-195.
11. Tenesa A, Farrington SM, Prendergast JGD, Porteous ME, Walker M, et al. ((2008)) Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 40: 631-637.
12. Lubbe SJ, Whiffin N, Chandler I, Broderick P, Houlston RS, ((2012)) Relationship between 16 susceptbility loci and colorectal cancer phenotype in 3146 patients. Carcinogenesis 33: 108-112.
13. Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, et al. ((2007)) A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet 39: 984-988.
14. Zanke BW, Greenwood CMT, Rangrej J, Kkustra R, Tenesa A, et al. ((2007)) Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet 39: 989-994.
15. Matsuo K, Suzuki T, Ito H, Hosono S, Kawase T, et al. ((2009)) Association between an 8q24 locus and the risk of colorectal cancer in Japanese. BMC Cancer 9: 379.
16. Schafmayer C, Buch S, Volzke H, von Schonfels W, Egberts JH, et al. ((2009)) Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample. Int. J. Cancer 124: 75-80.
17. von Holst S, Picelli S, Elder D, Lenander C, Dalen J, et al. ((2010)) Association studies on 11 published colorectal cancer risk loci. Br J Cancer 103: 575-580.
18. Tomlinson IPM, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, et al. ((2008)) A genome-wide association study identifies colorectal cancer susceptibility loci on chromosome 10p14 and 8q23.3. Nat Genet 40: 623-630.
19. Xing J, Myers RE, He X, Qu F, Zhou F, et al. ((2011)) GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis. Eur J Cancer 47: 1699-1707.
20. Jaeger EEM, Woodford-Richens KL, Lockett M, Rowan AJ, Sawyer EJ, et al. ((2003)) An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome. Am J Hum Genet 72: 1261-1267.
21. Cao X, Eu KW, Kumarsinghe MP, Li HH, Loi C, Cheah PY, ((2006)) Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function. J Med Genet 43: e13.
22. Pittman AM, Naranjo S, Webb E, Broderick P, Lips EH, et al. ((2009)) The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression. Genome Res 19: 987-993.
23. Ahmadiyeh N, Pomerantz MM, Grisanzio C, Herman P, Jia L, et al. ((2010)) 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A 107: 9742-9746.
24. Sotelo J, Esposito D, Duhagon MA, Banfield K, Mehalko J, et al. ((2010)) Long-range enhancers on 8q24 regulate c-Myc. Proc Natl Acad Sci U S A 107: 3001-3005.
25. Wright JB, Brown SJ, Cole MD, ((2010)) Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells. Mol Cell Biol 30: 1411-1420.
26. Niittymäki I, Tuupanen S, Li Y, Järvinen H, Mecklin JP, et al. ((2011)) Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci. BMC Med Genet 12: 23.
27. Pittman AM, Naranjo S, Jalava SE, Twiss P, Ma Y, et al. ((2010)) Allelic variation at the 8q23.3 colorectal cancer risk locus functions as a cis-acting regulator of EIF3H. PLoS Genet 6: e1001126.
28. Peters U, Hutter CM, Hsu L, Schumacher FR, Conti DV, et al. ((2012)) Meta-analysis of new genome-wide association studies of colorectal cancer risk. Hum Genet 131: 217-234.