Acute and Long-Term Purkinje Cell Loss Following a Single Ethanol Binge During the Early Third Trimester Equivalent in the Rat

Alcoholism: Clinical and Experimental Research

Volumn 36, Issue 8, 2012, Pages 1365-1373

  Idrus, Nirelia M ^a   Napper, Ruth M A ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Apoptosis; Binge alcohol; Fetal alcohol; Purkinje cells; Stereology

Indexed keywords

ALCOHOL; CASPASE 3;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; APOPTOSIS; ARTICLE; CELL DEATH; CELL LOSS; CEREBELLUM; CEREBELLUM VERMIS; CONTROLLED STUDY; FEMALE; FETAL ALCOHOL SYNDROME; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PURKINJE CELL; RAT; STEREOLOGY; THIRD TRIMESTER PREGNANCY;

ALGORITHMS; ANIMALS; CASPASE 3; CELL DEATH; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBELLUM; ETHANOL; FEMALE; FETAL ALCOHOL SYNDROME; IMMUNOHISTOCHEMISTRY; PREGNANCY; PREGNANCY, ANIMAL; PRENATAL EXPOSURE DELAYED EFFECTS; PURKINJE CELLS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84864543811     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01743.x     Document Type: Article

References (51)

1. Abel EL, Sokol RJ (1987) Incidence of fetal alcohol syndrome and economic impact of FAS-related anomalies. Drug Alcohol Depend 19:51-70.
2. Altman J (1969) Autoradiographic and histological studies of postnatal neurogenesis. 3. Dating the time of production and onset of differentiation of cerebellar microneurons in rats. J Comp Neurol 136:269-293.
3. Altman J (1972) Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer. J Comp Neurol 145:399-463.
4. Altman J, Bayer SA (1985) Embryonic development of the rat cerebellum. III. Regional differences in the time of origin, migration, and settling of Purkinje cells. J Comp Neurol 231:42-65.
5. Bauer-Moffett C, Altman J (1977) The effect of ethanol chronically administered to preweanling rats on cerebellar development: a morphological study. Brain Res 119:249-268.
6. Bonthius DJ, West JR (1990) Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure. Alcohol Clin Exp Res 14:107-118.
7. Bonthius DJ, West JR (1991) Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt. Teratology 44:147-163.
8. Braendgaard H, Evans SM, Howard CV, Gundersen HJ (1990) The total number of neurons in the human neocortex unbiasedly estimated using optical disectors. J Microsc 157(Pt 3):285-304.
9. Clarren SK, Alvord EC Jr, Sumi SM, Streissguth AP, Smith DW (1978) Brain malformations related to prenatal exposure to ethanol. J Pediatr 92:64-67.
10. Dikranian K, Qin YQ, Labruyere J, Nemmers B, Olney JW (2005) Ethanol-induced neuroapoptosis in the developing rodent cerebellum and related brain stem structures. Brain Res Dev Brain Res 155:1-13.
11. Dobbing J (1974) The later growth of the brain and its vulnerability. Pediatrics 53:2-6.
12. Dobbing J, Sands J (1973) Quantitative growth and development of human brain. Arch Dis Child 48:757-767.
13. Dunty WC Jr, Chen S, Zucker RM, Dehart DB, Sulik KK (2001) Selective vulnerability of embryonic cell populations to ethanol-induced apoptosis: implications for alcohol-related birth defects and neurodevelopmental disorder. Alcohol Clin Exp Res 25:1523-1535.
14. Fenwick MA, Hurst PR (2002) Immunohistochemical localization of active caspase-3 in the mouse ovary: growth and atresia of small follicles. Reproduction 124:659-665.
15. Gil-Mohapel J, Boehme F, Kainer L, Christie BR (2010) Hippocampal cell loss and neurogenesis after fetal alcohol exposure: insights from different rodent models. Brain Res Rev 64:283-303.
16. Goodlett CR, Eilers AT (1997) Alcohol-induced Purkinje cell loss with a single binge exposure in neonatal rats: a stereological study of temporal windows of vulnerability. Alcohol Clin Exp Res 21:738-744.
17. Goodlett CR, Lundahl KR (1996) Temporal determinants of neonatal alcohol-induced cerebellar damage and motor performance deficits. Pharmacol Biochem Behav 55:531-540.
18. Goodlett CR, Marcussen BL, West JR (1990) A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss. Alcohol 7:107-114.
19. Goodlett CR, Thomas JD, West JR (1991) Long-term deficits in cerebellar growth and rotarod performance of rats following "binge-like" alcohol exposure during the neonatal brain growth spurt. Neurotoxicol Teratol 13:69-74.
20. Grant KA, Choi EY, Samson HH (1983) Neonatal ethanol exposure: effects on adult behavior and brain growth parameters. Pharmacol Biochem Behav 18(Suppl 1):331-336.
21. Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B (1988a) The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. Apmis 96:857-881.
22. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A, West MJ (1988b) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. Apmis 96:379-394.
23. Hamre KM, West JR (1993) The effects of the timing of ethanol exposure during the brain growth spurt on the number of cerebellar Purkinje and granule cell nuclear profiles. Alcohol Clin Exp Res 17:610-622.
24. Idrus NM, McGough NN, Riley EP, Thomas JD (2011) Administration of memantine during ethanol withdrawal in neonatal rats: effects on long-term ethanol-induced motor incoordination and cerebellar Purkinje cell loss. Alcohol Clin Exp Res 35:355-364.
25. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, Price MT, Stefovska V, Horster F, Tenkova T, Dikranian K, Olney JW (2000) Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 287:1056-1060.
26. Jankowski J, Miething A, Schilling K, Baader SL (2009) Physiological Purkinje cell death is spatiotemporally organized in the developing mouse cerebellum. Cerebellum 8:277-290.
27. Kelly SJ, Bonthius DJ, West JR (1987) Developmental changes in alcohol pharmacokinetics in rats. Alcohol Clin Exp Res 11:281-286.
28. Larsell O (1952) The morphogenesis and adult pattern of the lobules and fissures of the cerebellum of the white rat. J Comp Neurol 97:281-356.
29. Li Y, Fraser AM, Idrus NM, Loughnan A-K, Napper RMA (2002) Morphological features of apoptotic Purkinje cell death are visible soon after binge exposure to ethanol on post-natal day four: a transmission electron microscopy study. Alcohol Clin Exp Res 26:96A.
30. Light KE, Belcher SM, Pierce DR (2002) Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat. Neuroscience 114:327-337.
31. Little RE, Streissguth AP (1978) Drinking during pregnancy in alcoholic women. Alcohol Clin Exp Res 2:179-183.
32. Mahoney JC, Abbott LC, West JR (1997) Time course of Purkinje cell death following a single day of ethanol exposure in the neonatal rat. Alcohol Clin Exp Res 21:85A.
33. Maier SE, Miller JA, Blackwell JM, West JR (1999) Fetal alcohol exposure and temporal vulnerability: regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development. Alcohol Clin Exp Res 23:726-734.
34. Maier SE, West JR (2001) Regional differences in cell loss associated with binge-like alcohol exposure during the first two trimesters equivalent in the rat. Alcohol 23:49-57.
35. Mihalick SM, Crandall JE, Langlois JC, Krienke JD, Dube WV (2001) Prenatal ethanol exposure, generalized learning impairment, and medial prefrontal cortical deficits in rats. Neurotoxicol Teratol 23:453-462.
36. Olney JW, Tenkova T, Dikranian K, Muglia LJ, Jermakowicz WJ, D'Sa C, Roth KA (2002) Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol Dis 9:205-219.
37. Pauli J, Wilce P, Bedi KS (1995) Acute exposure to alcohol during early postnatal life causes a deficit in the total number of cerebellar Purkinje cells in the rat. J Comp Neurol 360:506-512.
38. Paxinos GWC (1986) The Rat Brain in Stereotaxic Coordinates. 2nd ed. Academic Press, Sydney, Australia.
39. Phillips SC, Cragg BG (1982) A change in susceptibility of rat cerebellar Purkinje cells to damage by alcohol during fetal, neonatal and adult life. Neuropathol Appl Neurobiol 8:441-454.
40. Pierce DR, Williams DK, Light KE (1999) Purkinje cell vulnerability to developmental ethanol exposure in the rat cerebellum. Alcohol Clin Exp Res 23:1650-1659.
41. Riley EP, McGee CL (2005) Fetal alcohol spectrum disorders: an overview with emphasis on changes in brain and behavior. Exp Biol Med (Maywood) 230:357-365.
42. Sowell ER, Jernigan TL, Mattson SN, Riley EP, Sobel DF, Jones KL (1996) Abnormal development of the cerebellar vermis in children prenatally exposed to alcohol: size reduction in lobules I-V. Alcohol Clin Exp Res 20:31-34.
43. Stephens CJ (1985) Alcohol consumption during pregnancy among Southern city women. Drug Alcohol Depend 16:19-29.
44. Sterio DC (1984) The unbiased estimation of number and sizes of arbitrary particles using the disector method. J Microsc 134:127-136.
45. Thomas JD, Goodlett CR, West JR (1998) Alcohol-induced Purkinje cell loss depends on developmental timing of alcohol exposure and correlates with motor performance. Brain Res Dev Brain Res 105:159-166.
46. Watson PE, McDonald B (1999) Nutrition During Pregnancy. Ministry of Health, Wellington, New Zealand.
47. West JR, Goodlett CR, Bonthius DJ, Hamre KM, Marcussen BL (1990) Cell population depletion associated with fetal alcohol brain damage: mechanisms of BAC-dependent cell loss. Alcohol Clin Exp Res 14:813-818.
48. West MJ, Slomianka L, Gundersen HJ (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231:482-497.
49. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW, Mak TW (1998) Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 12:806-819.
50. Wozniak DF, Hartman RE, Boyle MP, Vogt SK, Brooks AR, Tenkova T, Young C, Olney JW, Muglia LJ (2004) Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis 17:403-414.
51. Young C, Roth KA, Klocke BJ, West T, Holtzman DM, Labruyere J, Qin YQ, Dikranian K, Olney JW (2005) Role of caspase-3 in ethanol-induced developmental neurodegeneration. Neurobiol Dis 20:608-614.