Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine

Veterinary Parasitology

Volumn 188, Issue 3-4, 2012, Pages 261-267

  Jayashi, César M ^a   Kyngdon, Craig T ^a   Gauci, Charles G ^a   Gonzalez, Armando E ^b   Lightowlers, Marshall W ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS   (Peru)

Author keywords

Cysticercosis; Field trial; Immunization; Neurocysticercosis; Pigs; Taeniasis; TSOL16; TSOL18; Vaccine

Indexed keywords

ANTICESTODAL AGENT; CLASSICAL SWINE FEVER VIRUS VACCINE; QUIL A; RECOMBINANT TAENIA SOLIUM 16 ANTIGEN VACCINE; RECOMBINANT TAENIA SOLIUM 18 ANTIGEN VACCINE; RECOMBINANT VACCINE; UNCLASSIFIED DRUG; VIRUS VACCINE;

AGRICULTURAL WORKER; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; CESTODIASIS; CLASSICAL SWINE FEVER; CONTROLLED STUDY; CYST (RESTING STAGE); CYSTICERCOSIS; DRUG EFFICACY; ENDEMIC DISEASE; IMMUNIZATION; INFECTION CONTROL; NONHUMAN; OUTCOME ASSESSMENT; PARASITE TRANSMISSION; PERU; PIG FARMING; PROTECTION; RURAL AREA; SWINE; TAENIA SOLIUM;

ANIMALS; ANTIGENS, HELMINTH; CYSTICERCOSIS; HUMANS; IMMUNIZATION; INCIDENCE; PERU; RECOMBINANT PROTEINS; SWINE; SWINE DISEASES; TAENIA SOLIUM; VACCINES;

ANIMALIA; SUIDAE; SUS; TAENIA SOLIUM;

EID: 84864541222     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2012.03.055     Document Type: Article

References (31)

1. Assana E., Kyngdon C.T., Gauci C.G., Geerts S., Dorny P., De Deken R., Anderson G.A., Zoli A.P., Lightowlers M.W. Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon. Int. J. Parasitol. 2010, 40:515-519.
2. Bern C., Garcia H.H., Evans C., Gonzalez A.E., Verastegui M., Tsang V.C., Gilman R.H. Magnitude of the disease burden from neurocysticercosis in a developing country. Clin. Infect. Dis. 1999, 29:1203-1209.
3. Bøgh H.O., Rickard M.D., Lightowlers M.W. Studies on stage-specific immunity against Taenia taeniaeformis metacestodes in mice. Parasite Immunol. 1988, 10:255-264.
4. Cai X., Yuan G., Zheng Y., Luo X., Zhang S., Ding J., Jing Z., Lu C. Effective production and purification of the glycosylated TSOL18 antigen, which is protective against pig cysticercosis. Infect. Immun. 2008, 76:767-770.
5. Coleman P.G., Perry B.D., Woolhouse M.E. Endemic stability-a veterinary idea applied to human public health. Lancet 2001, 357:1284-1286.
6. de Aluja A.S., Villalobos A.N., Plancarte A., Rodarte L.F., Hernandez M., Sciutto E. Experimental Taenia solium cysticercosis in pigs: characteristics of the infection and antibody response. Vet. Parasitol. 1996, 61:49-59.
7. de Aluja A.S., Villalobos A.N., Plancarte A., Rodarte L.F., Hernandez M., Zamora C., Sciutto E. Taenia solium cysticercosis: immunity in pigs induced by primary infection. Vet. Parasitol. 1999, 81:129-135.
8. Flisser A., Gauci C.G., Zoli A., Martinez-Ocana J., Garza-Rodriguez A., Dominguez-Alpizar J.L., Maravilla P., Rodriguez-Canul R., Avila G., Aguilar-Vega L., Kyngdon C., Geerts S., Lightowlers M.W. Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens. Infect. Immun. 2004, 72:5292-5297.
9. Garcia H.H., Del Brutto O.H. Neurocysticercosis: updated concepts about an old disease. Lancet Neurol. 2005, 4:653-661.
10. Gauci C., Lightowlers M.W. Molecular cloning of genes encoding oncosphere proteins reveals conservation of modular protein structure in cestode antigens. Mol. Biochem. Parasitol. 2003, 127:193-198.
11. Gauci, C.G., Jayashi, C.M., Gonzalez, A.E., Lackenby, J., Lightowlers, M.W., in press. Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens. Vaccine.
12. Gauci C.G., Flisser A., Lightowlers M.W. A Taenia solium oncosphere protein homologous to host-protective Taenia ovis and Taenia saginata 18kDa antigens. Int. J. Parasitol. 1998, 28:757-760.
13. Gauci C.G., Ito A., Lightowlers M.W. Conservation of the vaccine antigen gene, TSOL18, among genetically variant isolates of Taenia solium. Mol. Biochem. Parasitol. 2006, 146:101-104.
14. Gemmell M.A. The Styx Field Trial: effect of treatment of the definitive host for tapeworms on larval forms in the intermediate host. Bull. World Health Organ. 1978, 56:433-443.
15. Gemmell M.A. Australasian contributions to an understanding of the epidemiology and control of hydatid disease caused by Echinococcus granulosus-past, present and future. Int. J. Parasitol. 1990, 20:431-456.
16. Gonzalez A.E., Falcon N., Gavidia C., Garcia H.H., Tsang V.C., Bernal T., Romero M., Gilman R.H. Time-response curve of oxfendazole in the treatment of swine cysticercosis. Am. J. Trop. Med. Hyg. 1998, 59:832-836.
17. Gonzalez A.E., Gauci C.G., Barber D., Gilman R.H., Tsang V.C., Garcia H.H., Verastegui M., Lightowlers M.W. Vaccination of pigs to control human neurocysticercosis. Am. J. Trop. Med. Hyg. 2005, 72:837-839.
18. Gonzalez A.E., Gavidia C., Falcon N., Bernal T., Verastegui M., Garcia H.H., Gilman R.H., Tsang V.C. Protection of pigs with cysticercosis from further infections after treatment with oxfendazole. Am. J. Trop. Med. Hyg. 2001, 65:15-18.
19. Johnson K.S., Harrison G.B., Lightowlers M.W., O'Hoy K.L., Cougle W.G., Dempster R.P., Lawrence S.B., Vinton J.G., Heath D.D., Rickard M.D. Vaccination against ovine cysticercosis using a defined recombinant antigen. Nature 1989, 338:585-587.
20. Keilbach N.M., de Aluja A.S., Sarti-Gutierrez E. A programme to control taeniasis-cysticercosis (T. solium): experiences in a Mexican village. Acta Leiden. 1989, 57:181-189.
21. Lescano A.G., Garcia H.H., Gilman R.H., Guezala M.C., Tsang V.C., Gavidia C.M., Rodriguez S., Moulton L.H., Green J.A., Gonzalez A.E. Swine cysticercosis hotspots surrounding Taenia solium tapeworm carriers. Am. J. Trop. Med. Hyg. 2007, 76:376-383.
22. Lightowlers M.W. Eradication of Taenia solium cysticercosis: a role for vaccination of pigs. Int. J. Parasitol. 1999, 29:811-817.
23. Lightowlers M.W. Vaccines against cysticercosis and hydatidosis: foundations in taeniid cestode immunology. Parasitology 2006, 55(Suppl.):S39-S43.
24. Lightowlers M.W. Eradication of Taenia solium cysticercosis: a role for vaccination of pigs. Int. J. Parasitol. 2010, 40:1183-1192.
25. Lightowlers M.W., Lawrence S.B., Gauci C.G., Young J., Ralston M.J., Maas D., Health D.D. Vaccination against hydatidosis using a defined recombinant antigen. Parasite Immunol. 1996, 18:457-462.
26. Lightowlers M.W., Rolfe R., Gauci C.G. Taenia saginata: vaccination against cysticercosis in cattle with recombinant oncosphere antigens. Exp. Parasitol. 1996, 84:330-338.
27. Pawlowski Z., Allan J., Sarti E. Control of Taenia solium taeniasis/cysticercosis: from research towards implementation. Int. J. Parasitol. 2005, 35:1221-1232.
28. Rajasekariah G.R., Rickard M.D., Mitchell G.F. Immunization of mice against infection with Taenia taeniaeformis using various antigens prepared from eggs oncospheres developing larvae and strobilocerci. Int. J. Parasitol. 1980, 10:315-324.
29. Sarti E., Schantz P.M., Avila G., Ambrosio J., Medina-Santillan R., Flisser A. Mass treatment against human taeniasis for the control of cysticercosis: a population-based intervention study. Trans. R. Soc. Trop. Med. Hyg. 2000, 94:85-89.
30. Schantz P.M., Cruz M., Sarti E., Pawlowski Z. Potential eradicability of taeniasis and cysticercosis. Bull. Pan Am. Health Organ. 1993, 27:397-403.
31. Sciutto E., Fragoso G., Trueba L., Lemus D., Montoya R.M., Diaz M.L., Govezensky T., Lomeli C., Tapia G., Larralde C. Cysticercosis vaccine: cross protecting immunity with T. solium antigens against experimental murine T. crassiceps cysticercosis. Parasite Immunol. 1990, 12:687-696.