HIT-antibodies promote their own antigen

Blood

Volumn 120, Issue 5, 2012, Pages 930-931

  Greinacher, Andreas ^a   Krauel, Krystin ^a   Jensch, Inga ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; EPITOPE; HEPARIN; HEPARIN PLATELET FACTOR 4 ANTIBODY; MONOCLONAL ANTIBODY; THROMBOCYTE FACTOR 4;

ANTIBODY TITER; ANTIGEN SPECIFICITY; ANTIPHOSPHOLIPID SYNDROME; AUTOIMMUNITY; BACTERIAL INFECTION; BINDING AFFINITY; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; IMMUNOPATHOGENESIS; NOTE; OPSONIZATION; PATHOGENICITY; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTE ACTIVATION;

EID: 84864533105     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-06-430694     Document Type: Note

References (10)

1. Sachais BS, Litvinov RI, Yarovoi SV, et al. Dynamic antibody-binding properties in the pathogenesis of HIT. Blood. 2012;120(5):1137-1142.
2. Amiral J, Vissac AM. Generation and pathogenicity of anti-platelet factor 4 antibodies: diagnostic implications. Clin Appl Thromb Hemost. 1999;5(Suppl 1):S28-S31.
3. Pauzner R, Greinacher A, Selleng K, Althaus K, Shenkman B, Seligsohn U. False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus. J Thromb Haemost. 2009;7(7):1070-1074.
4. Legnani C, Cini M, Pili C, Boggian O, Frascaro M, Palareti G. Evaluation of a new automated panel of assays for the detection of anti-PF4/heparin antibodies in patients suspected of having heparin-induced thrombocytopenia. Thromb Haemost. 2010;104(2):402-409.
5. Greinacher A, Gopinadhan M, Gunther JU, et al. Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies. Arterioscler Thromb Vasc Biol. 2006;26(10):2386-2393.
6. Rauova L, Poncz M, McKenzie SE, et al. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood. 2005; 105(1):131-138.
7. Warkentin TE, Kelton JG. Delayed-onset heparin-induced thrombocytopenia and thrombosis. Ann Intern Med. 2001;135(7):502-506.
8. Krauel K, Potschke C, Weber C, et al. Platelet factor 4 binds to bacteria, [corrected] inducing antibodies crossreacting with the major antigen in heparin-induced thrombocytopenia. Blood. 2011;117(4):1370-1378.
9. Warkentin TE, Kelton JG. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med. 2001;344(17):1286-1292.
10. Hursting MJ, Pai PJ, McCracken JE, et al. Platelet factor 4/heparin antibodies in blood bank donors. Am J Clin Pathol. 2010;134(5):774-780.