Prevalence of Sacral Spinal (Tarlov) Cysts in Persistent Genital Arousal Disorder

Journal of Sexual Medicine

Volumn 9, Issue 8, 2012, Pages 2047-2056

  Komisaruk, Barry R ^a,b   Lee, Huey Jen ^b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Genital Sensory Nerves; MRI; Persistent Genital Arousal Disorder; PGAD; Restless Genital Syndrome; Tarlov Cysts

Indexed keywords

ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; INCIDENCE; LOW BACK PAIN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERSISTENT GENITAL AROUSAL DISORDER; PREVALENCE; PRIORITY JOURNAL; SACRAL SPINAL CORD; SEXUAL AROUSAL DISORDER; TARLOV CYST;

EID: 84864522192     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02765.x     Document Type: Article

References (33)

1. Tarlov IM. Perineurial cysts of the spinal nerve roots. Arch Neurol Psychiatry 1938;40:1067-74.
2. Langdown AJ, Grundy JR, Birch NC. The clinical relevance of Tarlov cysts. J Spinal Disord Tech 2005;18:29-33.
3. Komisaruk BR, Whipple B, Beyer-Flores C. The science of orgasm. Baltimore: The Johns Hopkins University Press; 2006.
4. Leiblum SR, Nathan SG. Persistent sexual arousal syndrome: A newly discovered pattern of female sexuality. J Sex Marital Ther 2001;27:365-80.
5. Leiblum S, Nathan S. Persistent sexual arousal syndrome in women: A not uncommon but little recognized complaint. Sex Relat Ther 2002;17:191-8.
6. Leiblum S. Persistent genital arousal disorder: What it is and what it isn't. Contemp Sex July 26, 2006. Pages 1-21. Available at: (accessed April 18, 2012).
7. Leiblum S, Seehuus M, Goldmeier D, Brown C. Psychological, medical, and pharmacological correlates of persistent genital arousal disorder. J Sex Med 2007;4:1358-66.
8. Leiblum S. Persistent genital arousal disorder. Leiblum S, ed. Principles and practices of sex therapy. New York: Guilford Press; 2007:54-83.
9. Goldstein I, De EJB, Johnson J. Persistent sexual arousal syndrome and clitoral priapism. Goldstein I, Meston C, Davis S, Traish AM, eds. Women's sexual function and dysfunction: Study, diagnosis and treatment. London: Taylor and Francis; 2006:674-85.
10. Leiblum S, Seehuus M, Brown C. Persistent genital arousal: Disordered or normative aspect of female sexual response? J Sex Med 2007a;4:680-9.
11. Goldmeier D, Leiblum S. Interaction of organic and psychological factors in persistent genital arousal disorder in women: A report of six cases. Int J STD AIDS 2008;19:488-90.
12. Leiblum SR, Seehuus M. FSFI scores of women with persistent genital arousal disorder compared with published scores of women with female sexual arousal disorder and healthy controls. J Sex Med 2009;6:469-73.
13. Voyadzis JM, Bhargava P, Henderson FC. Tarlov cysts: A study of 10 cases with review of the literature. J Neurosurg 2001;95:25-32.
14. Kayali H, Duz B, Gonul E. Symptomatic sacral Tarlov cyst; Case report. J Ankara Med Sch 2003;25:103-6.
15. Singh PK, Singh VK, Azam A, Gupta S. Tarlov cyst and infertility: Case report. J Spinal Cord Med 2009;32:191-7.
16. Acosta FL Jr, Quinones-Hinojosa A, Schmidt MH, Weinstein PR. Diagnosis and management of sacral Tarlov cysts. Case report and review of the literature. Neurosurg Focus 2003;15:1-7. Article 15.
17. Waldinger MD, Schweitzer DH. Persistent genital arousal disorder in 18 Dutch women: Part II. A syndrome clustered with restless legs and overactive bladder. J Sex Med 2009;6:482-97.
18. Yoo P, Lee S, Bhagat N, Lee H-J. Sacral extradural meningeal cyst: Is it an incidental finding? Amer Soc Spine Radiol, 2006. Mtg Abst. Available at: (accessed April 18, 2012).
19. IsHak WW, Bokarius A, Jeffrey JK, Davis MC, Bakhta Y. Disorders of orgasm in women: A literature review of etiology and current treatments. J Sex Med 2010;7:3254-68.
20. Khan F, Spence VA, Kennedy G, Belch JJF. Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with chronic fatigue syndrome. Clin Physiol Funct Imaging 2003;23:282-5.
21. Waldinger MD, Venema PL, van Gils APG, de Lint GJ, Schweitzer DH. Stronger evidence for small fiber sensory neuropathy in restless genital syndrome: Two case reports in males. J Sex Med 2011;8:325-30.
22. Netter FH. The Ciba collection of medical illustrations. Nervous system. Part 1: Anatomy and physiology. Summit, NJ: Ciba Pharmaceutical; 1986.
23. Goldmeier D, Mears A, Hiller J, Crowley T, BASHH Special Interest Group for Sexual Dysfunction. Persistent genital arousal disorder: A review of the literature and recommendations for management. Int J STD AIDS 2009;20:373-7.
24. Anzellotti FR, Franciotti R, Bonanni L, Tamburro G, Perrucci MG, Thomas A, Pizzella V, Romani GL, Onofrj M. Persistent genital arousal disorder associated with functional hyperconnectivity of an epileptic focus. Neuroscience 2010;167:88-96.
25. Korda JB, Pfaus JG, Kellner CH, Goldstein I. Persistent genital arousal disorder (PGAD): Case report of long-term symptomatic management with electroconvulsive therapy. J Sex Med 2009;6:2901-9.
26. Waldinger MD, de Lint GJ, Venema PL, van Gils AP, Schweitzer DH. Successful transcutaneous electrical nerve stimulation in two women with restless genital syndrome: The role of A-delta- and C-nerve fibers. J Sex Med 2010a;7:1190-9.
27. Waldinger MD, Venema PL, van Gils AP, Schutter EM, Schweitzer DH. Restless genital syndrome before and after clitoridectomy for spontaneous orgasms: A case report. J Sex Med 2010;7:1029-34.
28. th World Congress on Pain, Int'l Assoc Study Pain, Montreal, 2010. Abst # PM105.
29. Wong RC, Manno M. An international internet survey of individuals with Tarlov cyst disease. 2008. Available at: (accessed April 18, 2012).
30. Anonymous. About neurostimulators and drug pumps. Available at: (accessed April 18, 2012).
31. Murphy KJ, Nussbaum DA, Schnupp S, Long D. Tarlov cysts: An overlooked clinical problem. Semin Musculoskelet Radiol 2011;15:163-7.
32. Young W. Sacral Tarlov cysts: Diagnosis and treatment. 2008. Available at: (accessed April 18, 2012).
33. Hiers RH, Long D, North RB, Oaklander AL. Hiding in plain sight: A case of Tarlov perineural cysts. J Pain 2010;11:833-7.