Successful transcutaneous electrical nerve stimulation in two women with restless genital syndrome: The role of aδ- and c-nerve fibers

Journal of Sexual Medicine

Volumn 7, Issue 3, 2010, Pages 1190-1199

  Waldinger, Marcel D ^a,b   de Lint, Govert J ^a   Venema, Pieter L ^a   van Gils, Ad P G ^a   Schweitzer, Dave H ^c  

^a LEYENBURG HOSPITAL   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c REINIER DE GRAAF HOSPITAL   (Netherlands)

Author keywords

Dorsal nerve of the clitoris; OAB; Persistent sexual arousal syndrome; PGAD; Pudendal neuropathy; ReGS; RLS; Small Fiber neuropathy; TENS

Indexed keywords

ADULT; AFFERENT NERVE GROUP 1; AFFERENT NERVE GROUP 1 DELTA; ARTICLE; CASE REPORT; DERMATOME; DYSESTHESIA; ELECTROENCEPHALOGRAPHY; FEMALE; FEMALE SEXUAL DYSFUNCTION; HORMONE DETERMINATION; HUMAN; INTERVIEW; NERVE FIBER C; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGASM DISORDER; OVERACTIVE BLADDER; PATIENT REFERRAL; PATIENT SATISFACTION; PRIORITY JOURNAL; PUBIC BONE; QUESTIONNAIRE; RESTLESS GENITAL SYNDROME; RESTLESS LEGS SYNDROME; SENSORY ANALYSIS; TRANSCUTANEOUS NERVE STIMULATION;

EID: 77950842872     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01578.x     Document Type: Article

References (39)

1. Leiblum SR, Nathan SG. Persistent sexual arousal syndrome: A newly discovered pattern of female sexuality. J Sex Marital Ther 2001, 27:365-80.
2. Goldmeier D, Leiblum SR. Persistent genital arousal in women-A new syndrome entity. Int J STD AIDS 2006, 17:215-6.
3. Waldinger MD, van Gils AP, Ottervanger HP, Vandenbroucke WVA, Tavy DLJ. Persistent genital arousal disorder in 18 Dutch women: Part 1. MRI, EEG and transvaginal ultrasonography investigations. J Sex Med 2009, 6:474-81.
4. Waldinger MD, Schweitzer DH. Persistent genital arousal disorder in 18 Dutch women: Part II. A syndrome clustered with restless legs and overactive bladder. J Sex Med 2009, 6:482-97.
5. Waldinger MD, Venema PL, van Gils APG, Schweitzer DH. New insights into restless genital syndrome: Static mechanical hyperesthesia and neuropathy of the nervus dorsalis clitoridis. J Sex Med 2009, 6:2778-87.
6. Waldinger MD, Venema PL, van Gils APG, Schutter EMJ, Schweitzer DH. Restless genital syndrome before and after clitoridectomy for spontaneous orgasms: A case report. J Sex Med 2009, in press
7. Basson R, Leiblum S, Brotto L, Derogatis L, Fourcroy J, Fugl-Myer K, Graziottin A, Heiman JR, Laan E, Meston C, van Lankveld J, Weijmar Schultz W. Definitions of women's sexual dysfunctions reconsidered: Advocating expansion and revision. J Psychosom Obstet Gynaecol 2003, 24:221-9.
8. Walters AS. Toward a better definition of the restless legs syndrome. Mov Disord 1995, 10:634-42.
9. Section on clinical electrophysiology and American Physical Therapy Association. 2001, Electrotherapy Standards Committee: Electrotherapeutic terminology in physical therapy, report, Alexandria, VA
10. Hoitsma E, Reulen JPH, de Baets M, Drent M, Spaans F, Faber CG. Small fiber neuropathy: A common and important clinical disorder. J Neurol Sciences 2004, 227:119-30.
11. Maeda Y, Lisi TL, Vance CGT, Sluka KA. Release of GABA and activation of GABA-A in the spinal cord mediates the effects of TENS in rats. Brain Res 2007, 1136:43-50.
12. Wall PD, Sweet WH. Temporary abolition of pain in man. Science 1967, 155:108-9.
13. Melzack R, Wall PD. Pain mechanisms: A new theory. Science 1965, 150:971-8.
14. Fields HL, Basbaum AL. Endogenous pain control systems: Brainstem and spinal pathways and endorphin circuitry. Textbook of pain 1999, 308-38. Melzack R, Wall PD. In, eds., London, Churchill Livingstone
15. Sluka KA, Lisi TL, Westlund KN. Increased release of serotonin in the spinal cord during low, but not high, frequency transcutaneous electric nerve stimulation in rats with joint inflammation. Arch Phys Med Rehabil 2006, 87:1137-40.
16. Radhakrishnan R, King EW, Dickman J, Richtsmeier C, Schardt N, Spurgin M, Sluka KA. Blockade of spinal 5-HT receptor subtypes prevents low, but not high, frequency TENS-induced antihyperalgesia in rats. Pain 2003, 105:205-13.
17. Sivilotti L, Woolf CJ. The contribution of GABA-A and glycine receptors to central sensitization: Disinhibition and touch-evoked allodynia in the spinal cord. J Neurophysiol 1994, 72:169-79.
18. Kawamata T, Omote K, Toriyabe M, Kawamata M, Namiki A. Intracerebroventricular morphine produces antinociception by evoking gamma-aminobutyric acid release through activation of 5-hydroxytryptamine 3 receptors in the spinal cord. Anesthesiology 2002, 96:1175-82.
19. Lin Q, Peng YB, Willis WD. Glycine GABA(A) antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal gray. Brain Res 1994, 654:286-302.
20. Sluka KA, Daecon M, Stibal A, Strissel S, Terpstra A. Spinal blockade of opioid receptors prevents the analgesia produced by TENS in arthritic rats. J Pharmacol Exp Ther 1999, 289:840-6.
21. Kalra A, Urban MO, Sluka KA. Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS). J Pharmacol Exp Ther 2001, 298:257-63.
22. Fox A, Kesingland A, Gentry C, McNair K, Patel S, Urban L, James I. The role of central and peripheral Cannabinoid receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain 2001, 92:91-100.
23. Woolf CJ, Mitchell D, Barrett GD. Antinociceptive effect of peripheral segmental electrical stimulation in the rat. Pain 1980, 8:237-52.
24. Khan IM, Buerkle H, Taylor P, Yaksh TL. Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists. Neuropharmacology 1998, 37:1515-25.
25. Young T, Wittenauer S, Parker R, Vincler M. Peripheral nerve injury alters spinal nicotinic acetylcholine receptor pharmacology. Eur J Pharmacol 2008, 590:163-9.
26. Khan IM, Stanislaus S, Zhang L, Taylor P, Yaksh TL. A-85380 and epibatidine each interact with disparate spinal nicotinic receptor subtypes to achieve analgesia and nociception. J Pharmacol Exp Ther 2001, 297:230-9.
27. Rashid MH, Furue H, Yoshimura M, Ueda H. Tonic inhibitory role of α4β2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice. Pain 2006, 125:125-35.
28. Rashid MH, Ueda H. Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism. Brain Res 2002, 953:53-62.
29. Lacomis D. Small-fiber neuropathy. Muscle Nerve 2002, 26:173-88h.
30. Korda JB, Pfaus JG, Goldstein I. Persistent genital arousal disorder: A case report in a woman with lifelong PGAD where serendipitous administration of Varenicline Tartrate resulted in symptomatic improvement. J Sex Med 2009, 6:1479-86.
31. Yero SA, McKinney T, Petrides G, Goldstein I, Kellner CH. Successful use of electroconvulsive therapy in 2 cases of persistent sexual arousal syndrome and bipolar disorder. J ECT 2006, 22:274-5.
32. Deisenhammer EA, Trawoger R. Penile anesthesia associated with sertraline use. J Clin Psychiatry 1999, 60:869-70.
33. Modell JG. Repeated observations of yawning, clitoral engorgement, and orgasm associated with fluoxetine administration. J Clin Psychopharmacol 1989, 9:63-5.
34. Paea CU, Kima TS, Leeb KU, Kima JJ, Leea CU, Leea SJ, Leea CL, Paika IH. Paroxetine-associated spontaneous sexual stimulation. Int Clin Psychopharmacol 2005, 20:339-41.
35. Yokoyama T, Nozaki K, Fujita O, Nose H, Inoue M, Kumon H. Role of C afferent fibers and monitoring of intravesical resiniferatoxin therapy for patients with idiopathic detrusor overactivity. J Urol 2004, 172:596-600.
36. Polydefkis M, Allen RP, Hauer P, Earley CJ, Griffin JW, McArthur JC. Subclinical sensory neuropathy in late-onset restless legs syndrome. Neurology 2000, 55:1115-21.
37. Shukla G, Bhatia M, Behari M. Quantitative thermal sensory testing-Value of testing for both cold and warm sensation detection in evaluation of small fiber neuropathy. Muscle Nerve 1999, 22:523-31.
38. Fruhstorfer H, Harju EL, Lindblom UF. The significance of A-delta and C fibres for the perception of synthetic heat. Eur J Pain 2003, 7:63-71.
39. Treede RD, Kenshalo DR, Gracely RH, Jones AK. The cortical representaton of pain. Pain 1999, 79:105-11.