Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines

Cancer Cell International

Volumn 12, Issue , 2012, Pages

  Teodoro, Anderson J ^a   Oliveira, Felipe L ^b   Martins, Nathalia B ^b   Maia, Guilherme de A ^b   Martucci, Renata B ^b   Borojevic, Radovan ^c  

^a FEDERAL UNIVERSITY OF THE STATE OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Excellion Biomedical Services   (Brazil)

Author keywords

Bioactive compounds; Cancer; Cell cycle; Lycopene

Indexed keywords

LYCOPENE;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL;

EID: 84864520084     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-12-36     Document Type: Article

References (41)

1. Dorgan JF, Sowell A, Swanson CA, Potischman N, Miller R, Schussler N, Stephenson HE. Relationship of serum carotenoids, retinal, alpha-tocopherol and selenium with breast cancer risk:results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control 1998, 9:89-97. 10.1023/A:1008857521992, 9486468.
2. Tang L, Jin T, Zeng X, Wang JS. Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. J Nutr 2005, 135:287-290.
3. Franceschi S, Bidoli E, La Vecchia C, Talamini R, D'Avanzo B, Negri E. Tomatoes and risk of digestive-tract cancers. Int J Cancer 1994, 59:181-184. 10.1002/ijc.2910590207, 7927916.
4. Erhardt JG, Meisner C, Bode JC, Bode C. Lycopene, beta-carotene, and colorectal adenomas. Am J Clin Nutr 2003, 78:1219-1224.
5. Guttenplan JB, Chen M, Kosinska W, Thompson S, Zhao Z, Cohen LA. Effects of a lycopene-rich diet on spontaneous and benzo(a)pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse. Cancer Lett 2001, 164:1-6. 10.1016/S0304-3835(00)00705-9, 11166909.
6. Kucuk O, Sarkar FH, Sakr W, Djuric Z, Pollak MN, Khachik F, Li YW, Banerjee M, Grignon D, Bertram JS. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomarkers Prev 2001, 10(8):861-868.
7. Ansari MS, Gupta NP. Lycopene: A novel drug therapy in hormone refractory metastatic prostate cancer. Urol Oncol 2004, 22(5):415-420.
8. Wertz K, Siler U, Goralczyk R. Lycopene: modes of action to promote prostate health. Arch Biochem Biophys 2004, 430(1):127-134. 10.1016/j.abb.2004.04.023, 15325920.
9. Kumar NB, Besterman-Dahan K, Kang L, Pow-Sang J, Xu P, Allen K, Riccardi D, Krischer JP. Results of a Randomized Clinical Trial of the Action of Several Doses of Lycopene in Localized Prostate Cancer: Administration Prior to Radical Prostatectomy. Clin Med Urol 2008, 1:1-14. 2846655, 20354574.
10. Rao AV. Processed tomato products as a source of dietary lycopene:bioavailability and antioxidant properties. Can J Diet Pract Res 2004, 65:161-165. 10.3148/65.4.2004.161, 15596034.
11. Das S, Otani H, Maulik N, Das DK. Lycopene, tomatoes, and coronary heart disease. Free Radic Res 2005, 39:449-455. 10.1080/10715760500053685, 16032783.
12. Palozza P, Colangelo M, Simone R, Catalano A, Boninsegna A, Lanza P, Monego G, Ranelletti FO. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. Carcinogenesis 2010, 31(10):1813-1821. 10.1093/carcin/bgq157, 20699249.
13. Hwang ES, Bowen PE. Cell cycle arrest and induction of apoptosis by lycopene in LNCaP human prostate cancer cells. J Med Food 2004, 7(3):284-289. 10.1089/jmf.2004.7.284, 15383220.
14. Karas M, Amir H, Fishman D, et al. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. Nutr Cancer 2000, 36(1):101-111. 10.1207/S15327914NC3601_14, 10798222.
15. Burgess LC, Rice E, Fischer T, Seekins JR, Burgess TP, Sticka SJ, Klatt K. Lycopene has limited effect on cell proliferation in only two of seven human cell lines (both cancerous and noncancerous) in an in vitro system with doses across the physiological range. Toxicol in Vitro 2008, 22(5):1297-1300. 10.1016/j.tiv.2008.03.001, 2494863, 18434082.
16. Diehl JA. Cycling to cancer with cyclin D1. Cancer Biol Ther 2003, 1:226-231.
17. Park YO, Hwang ES, Moon TW. The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells. Biofactors 2005, 23:129-139. 10.1002/biof.5520230302, 16410635.
18. Ivanov NI, Cowell SP, Brown P, Rennie PS, Guns ES, Cox ME. Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines. Clin Nutr 2007, 26:252-263. 10.1016/j.clnu.2007.01.002, 17337101.
19. Teodoro AJ, Perrone D, Martucci RB, Borojevic R. Lycopene isomerisation and storage in an in vitro model of murine hepatic stellate cells. Eur J Nutr 2009, 48:261-268. 10.1007/s00394-009-0001-6, 19533199.
20. Hantz HL, Young LF, Martin KR. Physiologically attainable concentrations of lycopene induce mitochondrial apoptosis in LNCaP human prostate cancer cells. Exp Biol Med 2005, 230:171-179.
21. Prakash P, Russel RM, Krinsky NI. In vitro inhibition of proliferation of estrogendependent and estrogen-independent human breast cancer cells treated with carotenoids or retinoids. Nutr Cancer 2001, 131:1574-1580.
22. Livny O, Kaplan I, Reifen R, Polak-Charcon S, Madar Z. Lycopene inhibits proliferation and enhances gap-junctional communication on KB-1 human oral tumor cells. J Nutr 2002, 132:3754-3759.
23. Fornelli F, Leone A, Verdesca I, Minervini F, Zacheo G. The influence of lycopene on the proliferation of human breast cell line (MCF-7). Toxicol In Vitro 2007, 21:217-223. 10.1016/j.tiv.2006.09.024, 17140762.
24. Salman H, Bergman M, Djaldetti M, Bessler H. Lycopene affects proliferation and apoptosis of four malignant cell lines. Biomed Pharmacother 2007, 61:366-369. 10.1016/j.biopha.2007.02.015, 17448625.
25. Allen CM, Schwartz SJ, Craft NE, Giovannucci EL, De Groff VL, Clinton SK. Changes in plasma and oral mucosal lycopene isomer concentrations in healthy adults consuming standard servings of processed tomato products. Nutr Cancer 2003, 47(1):48-56. 10.1207/s15327914nc4701_6, 14769537.
26. Jenab M, Ferrari P, Mazuir M, Tjonneland A, Clavel-Chapelon F, Linseisen J, Trichopoulou A, Tumino R, Bueno-de-Mesquita HB, Lund E, Gonzalez CA, Johansson G, Key TJ, Riboli E. European Prospective Investigation into Cancer and Nutrition (EPIC) study. Variations in lycopene blood levels and tomato consumption across European countries based on the European Prospective Investigation into Cancer and Nutrition (EPIC) study. J Nutr 2005, 135(8):2032S-2036S.
27. Hirsch K, Atzmon A, Danilenko M, Levy J, Sharoni Y. Lycopene and other carotenoids inhibit estrogenic activity of 17beta-estradiol and genistein in cancer cells. Breast Cancer Res Treat 2007, 104(2):221-230. 10.1007/s10549-006-9405-7, 17051425.
28. Galluzzo P, Martini C, Bulzomi P, Leone S, Bolli A, Pallottini V, Marino M. Quercetin-induced apoptotic cascade in cancer cells: antioxidant versus estrogen receptor alpha-dependent mechanisms. Mol Nutr Food Res 2009, 53(6):699-708. 10.1002/mnfr.200800239, 19194971.
29. Liu A, Pajkovic N, Pang Y, Zhu D, Calamini B, Mesecar AL, van Breemen RB. Absorption and subcellular localization of lycopene in human prostate cancer cells. Mol Cancer Ther 2006, 5:2879-2885. 10.1158/1535-7163.MCT-06-0373, 17121935.
30. Ford NA, Elsen AC, Zuniga K, Lindshield BL, Erdman JW. Lycopene and Apo-12'-Lycopenal Reduce Cell Proliferation and Alter Cell Cycle Progression in Human Prostate Cancer Cells. Nutr Cancer 2011, 63(2):256-263. 10.1080/01635581.2011.523494, 21207319.
31. Mossine VV, Chopra P, Mawhinney TP. Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis. Cancer Res 2008, 68(11):4384-4391. 10.1158/0008-5472.CAN-08-0108, 18519700.
32. Yang CM, Yen YT, Huang CS, Hu ML. Growth inhibitory efficacy of lycopene and β-carotene against androgen-independent prostate tumor cells xenografted in nude mice. Mol Nutr Food Res 2011, 55(4):606-612. 10.1002/mnfr.201000308, 21462328.
33. Bissell MJ, Le Beyec J, Anderson RL. Prostate Cancer in Bone: Importance of Context for Inhibition of Matrix Metalloproteinases. J Natl Cancer Inst 2002, 94(1):4-5. 10.1093/jnci/94.1.4, 3027556, 11773268.
34. Ellinger S, Ellinger J, Stehle P. Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies?. Curr Opin Clin Nutr Metab Care 2006, 9(6):722-727. 10.1097/01.mco.0000247470.64532.34, 17053426.
35. Palozza P, Serini S, Boninsegna A, Bellovini D, Lucarini M, Monastra G, Gaetani S. The growth-inhibitory effects of tomatoes digested in nitro in colon adenocarcinomacells occur through down-regulation of cyclin D1, Bcl-2 and Bcl-XL. Br J Nutr 2007, 98:789-795.
36. Nahum A, Hirsch K, Danilenko M, Watts CK, Prall OW, Levy J, Sharoni Y. Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes. Oncogene 2001, 20:3428-3436. 10.1038/sj.onc.1204452, 11423993.
37. Tang FY, Shih CJ, Cheng LH, Ho HJ, Chen HJ. Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway. Mol Nutr Food Res 2008, 52:646-654. 10.1002/mnfr.200700272, 18537129.
38. Nahum A, Zeller L, Danilenko M, Prall OW, Watts CK, Sutherland RL, Levy J, Sharoni Y. Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1. Eur J Nutr 2006, 45(5):275-282. 10.1007/s00394-006-0595-x, 16565789.
39. Rathinasamy K, Jindal B, Asthana J, Singh P, Balaji PV, Panda D. Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine. BMC Cancer 2010, 9(10):213.
40. Levy J, Bosin E, Feldman B, Giat Y, Miinster A, Danilenko M, Sharoni Y. Lycopene is a more potent inhibitor of human cancer cell proliferation than either alpha-carotene or beta-carotene. Nutr Cancer 1995, 24:257-266. 10.1080/01635589509514415, 8610045.
41. Vindelov LL. Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei. Virchows Arch B Cell Pathol 1977, 24(3):227-242.