Erectile Dysfunction Is Not Independently Associated with Cardiovascular Death: Data from the Vitamins and Lifestyle (VITAL) Study

Journal of Sexual Medicine

Volumn 9, Issue 8, 2012, Pages 2104-2110

  Hotaling, James M ^a   Walsh, Thomas J ^a   Macleod, Liam Connor ^a   Heckbert, Susan ^b   Pocobelli, Gaia ^b   Wessells, Hunter ^a   White, Emily ^c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c USA   (United States)

Author keywords

Aging; Cardiovascular Death; Cardiovascular Events; Erectile Dysfunction; Impotence; Risk Factors

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT;

ADULT; AGE; AGED; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIABETES MELLITUS; DISEASE ASSOCIATION; ERECTILE DYSFUNCTION; EXERCISE; FAMILY HISTORY; HEART DEATH; HEART INFARCTION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MARRIAGE; PATIENT EDUCATION; PRIORITY JOURNAL; QUESTIONNAIRE; SELF EVALUATION; SMOKING; STROKE; VITAMIN SUPPLEMENTATION;

EID: 84864518010     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02826.x     Document Type: Article

References (26)

1. Droller M. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993;270:83-90.
2. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB. Heart disease and stroke statistics-2011 update: A report from the American Heart Association. Circulation 2011;123:e18-209.
3. Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA. Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005;294:2996-3002.
4. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
5. Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinlay JB. Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts male aging study. J Urol 2000;163:460-3.
6. Nicolosi A, Moreira ED Jr, Shirai M, Bin Mohd Tambi MI, Glasser DB. Epidemiology of erectile dysfunction in four countries: Cross-national study of the prevalence and correlates of erectile dysfunction. Urology 2003;61:201-6.
7. Saigal CS, Wessells H, Pace J, Schonlau M, Wilt TJ. Predictors and prevalence of erectile dysfunction in a racially diverse population. Arch Intern Med 2006;166:207-12.
8. Garcia-Malpartida K, Marmol R, Jover A, Gómez-Martínez MJ, Solá-Izquierdo E, Victor VM, Rocha M, Sanmiguel D, Hernández-Mijares A. Relationship between erectile dysfunction and silent myocardial ischemia in type 2 diabetic patients with no known macrovascular complications. J Sex Med 2011;8:2606-16.
9. Guo W, Liao C, Zou Y, Li F, Li T, Zhou Q, Cao Y, Mao X. Erectile dysfunction and risk of clinical cardiovascular events: A meta-analysis of seven cohort studies. J Sex Med 2010;7:2805-16.
10. Chew KK, Finn J, Stuckey B, Gibson N, Sanfilippo F, Bremner A, Thompson P, Hobbs M, Jamrozik K. Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: Findings from a linked-data study. J Sex Med 2010;7:192-202.
11. Inman BA, Sauver JL, Jacobson DJ, McGree ME, Nehra A, Lieber MM, Roger VL, Jacobsen SJ. A population-based, longitudinal study of erectile dysfunction and future coronary artery disease. Mayo Clin Proc 2009;84:108-13.
12. Cordero A, Bertomeu-Martinez V, Mazon P, Facila L, Gonzalez-Juanatey JR. Erectile dysfunction may improve by blood pressure control in patients with high-risk hypertension. Postgrad Med 2010;122:51-6.
13. Salem S, Abdi S, Mehrsai A, Saboury B, Saraji A, Shokohideh V, Pourmand G. Erectile dysfunction severity as a risk predictor for coronary artery disease. J Sex Med 2009;6:3425-32.
14. El-Sakka AI, Morsy AM, Fagih BI. Severity of erectile dysfunction could predict left ventricular diastolic dysfunction in patients without overt cardiac complaint. J Sex Med 2011;8:2590-7.
15. Chew KK, Gibson N, Sanfilippo F, Stuckey B, Bremner A. Cardiovascular mortality in men with erectile dysfunction: Increased risk but not inevitable. J Sex Med 2011;8:1761-71.
16. Ponholzer A, Gutjahr G, Temml C, Madersbacher S. Is erectile dysfunction a predictor of cardiovascular events or stroke? A prospective study using a validated questionnaire. Int J Impot Res 2010;22:25-9.
17. Araujo AB, Travison TG, Ganz P, Chiu GR, Kupelian V, Rosen RC, Hall SA, McKinlay JB. Erectile dysfunction and mortality. J Sex Med 2009;6:2445-54.
18. Bohm M, Baumhakel M, Teo K, Sleight P, Probstfield J, Gao P, Mann JF, Diaz R, Dagenais GR, Jennings GL, Liu L, Jansky P, Yusuf S. Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (ONTARGET/TRANSCEND) Trials. Circulation 2010;121:1439-46.
19. Bruemmer B, White E, Vaughan TL, Cheney CL. Nutrient intake in relation to bladder cancer among middle-aged men and women. Am J Epidemiol 1996;144:485-95.
20. Costa C, Virag R. The endothelial-erectile dysfunction connection: An essential update. J Sex Med 2009;6:2390-404.
21. Arana Rosainz Mde J, Ojeda MO, Acosta JR, Elías-Calles LC, González NO, Herrera OT, García Álvarez CT, Rodríguez EM, Báez ME, Seijas EÁ, Valdés RF. Imbalanced low-grade inflammation and endothelial activation in patients with type 2 diabetes mellitus and erectile dysfunction. J Sex Med 2011;8:2017-30.
22. Kirby MG, Schnetzler G, Zou KH, Symonds T. Prevalence and detection rate of underlying disease in men with erectile dysfunction receiving phosphodiesterase type 5 inhibitors in the United Kingdom: A retrospective database study. Int J Clin Pract 2011;65:797-806.
23. Gleason JM, Slezak JM, Jung H, Reynolds K, Van den Eeden SK, Haque R, Quinn VP, Loo RK, Jacobsen SJ. Regular nonsteroidal anti-inflammatory drug use and erectile dysfunction. J Urol 2011;185:1388-93.
24. Zusman RM, Morales A, Glasser DB, Osterloh IH. Overall cardiovascular profile of sildenafil citrate. Am J Cardiol 1999;83:35C-44C.
25. Hodges LD, Kirby M, Solanki J, O'Donnell J, Brodie DA. The temporal relationship between erectile dysfunction and cardiovascular disease. Int J Clin Pract 2007;61:2019-25.
26. Cordero A, Bertomeu-Martinez V, Mazon P, Fácila L, Bertomeu-González V, Conthe P, González-Juanatey JR. Erectile dysfunction in high-risk hypertensive patients treated with beta-blockade agents. Cardiovasc Ther 2010;28:15-22.