Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 31, 2012, Pages 12485-12490

  Zhang, Xin ^a,b   Wang, Wenchao ^a,b   Bedigian, Anne V ^a   Coughlin, Margaret L ^a   Mitchison, Timothy J ^a   Eggert, Ulrike S ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Drug off target effects; Endocytic tubulation; Membrane trafficking; Small molecule inhibitor; Unconventional G protein coupled receptor function

Indexed keywords

ADRENERGIC RECEPTOR; COAT PROTEIN COMPLEX I; COATOMER PROTEIN; DOPAMINE 3 RECEPTOR; G PROTEIN COUPLED RECEPTOR; PRAZOSIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DRD3 PROTEIN, HUMAN;

ARTICLE; CELL DIVISION; CELL SELECTION; CYTOKINESIS; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; PRIORITY JOURNAL; RNA INTERFERENCE; ACTIVE TRANSPORT; DRUG EFFECT; GENETICS; HELA CELL; METABOLISM; PROTEIN STABILITY;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; BIOLOGICAL TRANSPORT, ACTIVE; COAT PROTEIN COMPLEX I; ENDOCYTOSIS; ENDOSOMES; HELA CELLS; HUMANS; PRAZOSIN; PROTEIN STABILITY; RECEPTORS, DOPAMINE D3;

EID: 84864510533     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207821109     Document Type: Article

References (34)

1. Lappano R, Maggiolini M (2011) G protein-coupled receptors: Novel targets for drug discovery in cancer. Nat Rev Drug Discov 10:47-60.
2. Rosenbaum DM, Rasmussen SG, Kobilka BK (2009) The structure and function of G-protein-coupled receptors. Nature 459:356-363.
3. Platta HW, Stenmark H (2011) Endocytosis and signaling. Curr Opin Cell Biol 23: 393-403.
4. Hanyaloglu AC, von Zastrow M (2008) Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu Rev Pharmacol Toxicol 48:537-568. (Pubitemid 351738163)
5. Cavalli V, Corti M, Gruenberg J (2001) Endocytosis and signaling cascades: A close encounter. FEBS Lett 498:190-196. (Pubitemid 32539201)
6. Gould GW, Lippincott-Schwartz J (2009) New roles for endosomes: From vesicular carriers to multi-purpose platforms. Nat Rev Mol Cell Biol 10:287-292.
7. Gruenberg J (2001) The endocytic pathway: A mosaic of domains. Nat Rev Mol Cell Biol 2:721-730.
8. van Weering JR, Verkade P, Cullen PJ (2010) SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting. Semin Cell Dev Biol 21:371-380.
9. Lippincott-Schwartz J, et al. (1991) Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67:601-616. (Pubitemid 121001474)
10. Deng Y, Golinelli-Cohen MP, Smirnova E, Jackson CL (2009) A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor. EMBO Rep 10: 58-64.
11. Available at http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000625/. Accessed June 30, 2012.
12. Eggert US, et al. (2004) Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol 2:e379.
13. Guizetti J, Gerlich DW (2010) Cytokinetic abscission in animal cells. Semin Cell Dev Biol 21:909-916.
14. Collinet C, et al. (2010) Systems survey of endocytosis by multiparametric image analysis. Nature 464:243-249.
15. Hunziker W, Mâle P, Mellman I (1990) Differential microtubule requirements for transcytosis in MDCK cells. EMBO J 9:3515-3525.
16. Kok JW, Hoekstra K, Eskelinen S, Hoekstra D (1992) Recycling pathways of glucosylceramide in BHK cells: Distinct involvement of early and late endosomes. J Cell Sci 103:1139-1152. (Pubitemid 23042258)
17. Matter K, Bucher K, Hauri HP (1990) Microtubule perturbation retards both the direct and the indirect apical pathway but does not affect sorting of plasma membrane proteins in intestinal epithelial cells (Caco-2). EMBO J 9:3163-3170.
18. Aniento F, Emans N, Griffiths G, Gruenberg J (1993) Cytoplasmic dynein-dependent vesicular transport from early to late endosomes. J Cell Biol 123:1373-1387. (Pubitemid 24012018)
19. Elphick GF, et al. (2004) The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science 306:1380-1383. (Pubitemid 39532516)
20. Sachlos E, et al. (2012) Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell 149:1284-1297.
21. Allen JA, et al. (2011) Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci USA 108:18488-18493.
22. Jeanneteau F, Diaz J, Sokoloff P, Griffon N (2004) Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Mol Biol Cell 15:696-705. (Pubitemid 38146486)
23. McMahon HT, Mills IG (2004) COP and clathrin-coated vesicle budding: Different pathways, common approaches. Curr Opin Cell Biol 16:379-391. (Pubitemid 38903144)
24. Beck R, Rawet M, Wieland FT, Cassel D (2009) The COPI system: Molecular mechanisms and function. FEBS Lett 583:2701-2709.
25. Gu F, Aniento F, Parton RG, Gruenberg J (1997) Functional dissection of COP-I subunits in the biogenesis of multivesicular endosomes. J Cell Biol 139:1183-1195. (Pubitemid 27523206)
26. Aniento F, Gu F, Parton RG, Gruenberg J (1996) An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes. J Cell Biol 133:29-41. (Pubitemid 126618595)
27. Razi M, Chan EY, Tooze SA (2009) Early endosomes and endosomal coatomer are required for autophagy. J Cell Biol 185:305-321.
28. Gu F, Gruenberg J (2000) ARF1 regulates pH-dependent COP functions in the early endocytic pathway. J Biol Chem 275:8154-8160. (Pubitemid 30159730)
29. Whitney JA, Gomez M, Sheff D, Kreis TE, Mellman I (1995) Cytoplasmic coat proteins involved in endosome function. Cell 83:703-713.
30. Popoff V, Adolf F, Brügger B, Wieland F (2011) COPI budding within the Golgi stack. Cold Spring Harb Perspect Biol 3:a005231.
31. Ilani T, et al. (2002) Coupling of dopamine receptors to G proteins: Studies with chimeric D2/D3 dopamine receptors. Cell Mol Neurobiol 22:47-56. (Pubitemid 34579408)
32. Neve KA (2010) The Dopamine Receptors (Springer, New York), 2nd Ed.
33. Fegan A, White B, Carlson JC, Wagner CR (2010) Chemically controlled protein assembly: Techniques and applications. Chem Rev 110:3315-3336.
34. Smith NJ, Milligan G (2010) Allostery at G protein-coupled receptor homo- and heteromers: Uncharted pharmacological landscapes. Pharmacol Rev 62:701-725.