Accumulation of instability in serial differentiation and reprogramming of parthenogenetic human cells

Human Molecular Genetics

Volumn 21, Issue 15, 2012, Pages 3366-3373

  Vassena, Rita ^a,d   Montserrat, Nuria ^a   Canal, Beatriz Carrasco ^b   Aran, Begoña ^a   de Oñate, Lorena ^a   Veiga, Anna ^a,b   Belmonte, Juan Carlos Izpisua ^a,c  

^a CENTER OF REGENERATIVE MEDICINE IN BARCELONA   (Spain)

^b INSTITUT UNIVERSITARI DEXEUS   (Spain)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d Clinica EUGIN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SOX2;

ARTICLE; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ASSOCIATION; HETEROZYGOSITY; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; NUCLEAR REPROGRAMMING; NUCLEOTIDE SEQUENCE; OOCYTE; PARTHENOGENESIS; PRIORITY JOURNAL;

CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; HISTOCOMPATIBILITY TESTING; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MESENCHYMAL STROMAL CELLS; MICROSATELLITE REPEATS; NUCLEAR REPROGRAMMING; PARTHENOGENESIS;

IPS; PIPS;

EID: 84864506177     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds168     Document Type: Article

References (15)

1. Feldheim, K.A., Chapman, D.D., Sweet, D., Fitzpatrick, S., Prodöhl, P.A., Shivji, M.S. and Snowden, B. (2010) Shark virgin birth produces multiple, viable offspring. J. Hered., 101, 374-377.
2. de Fried, E.P., Ross, P., Zang, G., Divita, A., Cunniff, K., Denaday, F., Salamone, D., Kiessling, A. and Cibelli, J. (2008) Human parthenogenetic blastocysts derived from noninseminated cryopreserved human oocytes. Fertil. Steril., 89, 943-947.
3. Cibelli, J.B., Grant, K.A., Chapman, K.B., Cunniff, K., Worst, T., Green, H.L., Walker, S.J., Gutin, P.H., Vilner, L., Tabar, V. et al. (2002) Parthenogenetic stem cells in nonhuman primates. Science, 295, 819.
4. Lin, G., OuYang, Q., Zhou, X., Gu, Y., Yuan, D., Li, W., Liu, G., Liu, T. and Lu, G. (2007) A highly homozygous and parthenogenetic human embryonic stem cell line derived from a one-pronuclear oocyte following in vitro fertilization procedure. Cell Res., 17, 999-1007.
5. Stadtfeld, M., Apostolou, E., Akutsu, H., Fukuda, A., Follett, P., Natesan, S., Kono, T., Shioda, T. and Hochedlinger, K. (2010) Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature, 465, 175-181.
6. Buiting, K. (2010) Prader-Willi syndrome and Angelman syndrome. Am. J. Med. Genet., 154C, 365-376.
7. Aran, B., Rodriguez-Piza, I., Raya, A., Consiglio, A., Muñoz, Y., Barri, P.N., Izpisúa, J.C. and Veiga, A. (2010) Derivation of human embryonic stem cells at the Center of Regenerative Medicine in Barcelona. In Vitro Cell Dev., 46, 356-366.
8. Do, J.T., Joo, J.Y., Han, D.W., Araúzo-Bravo, M.J., Kim, M.J., Greber, B., Zaehres, H., Sobek-Klocke, I., Chung, H.M. and Schöler, H.R. (2009) Generation of parthenogenetic induced pluripotent stem cells from parthenogenetic neural stem cells. Stem Cells, 27, 2962-2968.
9. Hernandez, L., Kozlov, S., Piras, G. and Stewart, C.L. (2003) Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation. Proc. Natl Acad. Sci., 100, 13344-13349.
10. Stelzer, Y., Yanuka, O. and Benvenisty, N. (2011) Global analysis of parental imprinting in human parthenogenetic induced pluripotent stem cells. Nat. Struct. Mol. Biol., 18, 735-741.
11. Paffoni, A., Brevini, T.A., Somigliana, E., Restelli, L., Gandolfi, F. and Ragni, G. (2007) In vitro development of human oocytes after parthenogenetic activation or intracytoplasmic sperm injection. Fertil. Steril., 87, 77-82.
12. Aasen, T., Raya, A., Barrero, M.J., Garreta, E., Consiglio, A., Gonzalez, F., Vassena, R., Bilić, J., Pekarik, V., Tiscornia, G. et al. (2008) Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat. Biotechnol., 26, 1276-1284.
13. Park, T.S., Galic, Z., Conway, A.E., Lindgren, A., van Handel, B.J., Magnusson, M., Rcihter, L., Teitell, M.A., Mikkola, H.K., Lowry, W.E., Plath, K. and Clark, A.T. (2009) Derivation of primordial germ cells from human embryonic and induced plurpotent stem cells is significantly improved by coculture with human fetal gonadal cells. Stem Cells, 27, 783-795.
14. Irizarry, R.A., Bolstad, B.M., Collin, F., Cope, L.M., Hobbs, B. and Speed, T.P. (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res., 31, e15.
15. Smyth, G.K. (2004) Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol., 3, Article3.