Rational design of a fluorescent NADPH derivative imaging constitutive nitric-oxide synthases upon two-photon excitation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 31, 2012, Pages 12526-12531

  Li, Yun ^a   Wang, Huan ^b   Tarus, Bogdan ^c   Perez, Miguel Romero ^d   Morellato, Laurence ^a   Henry, Etienne ^b   Berka, Vladimir ^e   Tsai, Ah Lim ^e   Ramassamy, Booma ^a   Dhimane, Hamid ^a   Dessy, Chantal ^d   Tauc, Patrick ^b   Boucher, Jean Luc ^a   Deprez, Eric ^b   Slama Schwok, Anny ^c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b CNRS   (France)

^c INRA Institut National de la Recherche Agronomique   (France)

^d UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

^e UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Chemical biology; Fluorescence spectroscopy; Inhibition of enzymatic catalysis; Structure based design and molecular modeling; Two photon fluorescence imaging

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NANOSHUTTER 1; NITRIC OXIDE SYNTHASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; AUTOFLUORESCENCE; CATALYSIS; CONTROLLED STUDY; DRUG PROTEIN BINDING; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROCESS DESIGN; PROTEIN BINDING; PROTEIN LOCALIZATION; SIGNAL NOISE RATIO; SOLVATION; UMBILICAL VEIN ENDOTHELIAL CELL;

CATALYSIS; FLUORESCENT DYES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ISOENZYMES; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; MOLECULAR DYNAMICS SIMULATION; NADP; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III;

EID: 84864498716     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205645109     Document Type: Article

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