Preparation and evaluation of 99mTc-cefuroxime, a potential infection specific imaging agent: A reliable thin layer chromatographic system to delineate impurities from the 99mTc-antibiotic

Applied Radiation and Isotopes

Volumn 70, Issue 10, 2012, Pages 2384-2387

  Chattopadhyay, Sankha ^a   Ghosh, Mayuri ^b   Sett, Sucharita ^b   Das, Malay Kanti ^a   Chandra, Susmita ^c   De, Kakali ^c   Mishra, Mridula ^c   Sinha, Samarendu ^a   Ranjan Sarkar, Bharat ^a   Ganguly, Shantanu ^a  

^a VARIABLE ENERGY CYCLOTRON CENTRE   (India)

^b VIT UNIVERSITY   (India)

^c INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

99mTc cefuroxime; Inflammation imaging in animal model; Optimum parameters; Preparation; Radiochemical purity; RTLC reliable solvent systems

Indexed keywords

99MTC-CEFUROXIME; ANIMAL MODEL; OPTIMUM PARAMETERS; PREPARATION; RADIOCHEMICAL PURITY; SOLVENT SYSTEM;

CHROMATOGRAPHY; NUCLEAR MEDICINE; TECHNETIUM;

ANTIBIOTICS;

ANTIBIOTIC AGENT; CEFUROXIME; CEFUROXIME TC 99M; DIAGNOSTIC AGENT; PERTECHNETIC ACID TC 99M; SODIUM CHLORIDE; TECHNETIUM 99M; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; TECHNETIUM COMPLEX;

ABSCESS TO MUSCLE RATIO; ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CHEMICAL REACTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG IMPURITY; DRUG PURIFICATION; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; RADIOASSAY; RADIOCHEMISTRY; RAT; SCINTIGRAPHY; THIN LAYER CHROMATOGRAPHY; ANIMAL; CHEMISTRY; REPRODUCIBILITY; SCINTISCANNING; WISTAR RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; CEFUROXIME; ORGANOTECHNETIUM COMPOUNDS; RADIONUCLIDE IMAGING; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS;

EID: 84864497128     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2012.06.007     Document Type: Article

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