Involvement of parathyroid hormone-related protein in vascular calcification of chronic haemodialysis patients

Nephrology

Volumn 17, Issue 6, 2012, Pages 552-560

  Liu, Fang ^a   Fu, Ping ^a   Fan, Wenxing ^a   Gou, Rong ^a   Huang, Youqun ^a   Qiu, Hongyu ^a   Zhong, Hui ^a   Huang, Songmin ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

bone morphogenetic protein 2; Cbfa1; haemodialysis; parathyroid hormone related protein; vascular calcification

Indexed keywords

ALIZARIN; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; EOSIN; HEMATOXYLIN; MESSENGER RNA; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHORIC ACID DERIVATIVE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2;

ADULT; ARTICLE; BLOOD VESSEL CALCIFICATION; CALCIUM CELL LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ELASTIC FIBER; ENZYME ACTIVITY; FEMALE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFERIOR EPIGASTRIC ARTERY; KIDNEY CARCINOMA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; STAINING; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ADULT; ALKALINE PHOSPHATASE; AORTA; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; CASE-CONTROL STUDIES; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; EPIGASTRIC ARTERIES; FEMALE; GLYCEROPHOSPHATES; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PARATHYROID HORMONE-RELATED PROTEIN; REAL-TIME POLYMERASE CHAIN REACTION; RENAL DIALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAINING AND LABELING; TRANSFECTION; VASCULAR CALCIFICATION; YOUNG ADULT;

EID: 84864495816     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2012.01601.x     Document Type: Article

References (45)

1. London G, Coyne D, Hruska K, et al,. The new kidney disease: Improving global outcomes (KDIGO) guidelines-expert clinical focus on bone and vascular calcification. Clin. Nephrol. 2010; 74: 423-32.
2. Foley RN, Murray AM, Li S, et al,. Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998-1999. J. Am. Soc. Nephrol. 2005; 16: 489-95. (Pubitemid 41725146)
3. Goodman WG, Goldin J, Kuizon BD, et al,. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N. Engl. J. Med. 2000; 342: 1478-83. (Pubitemid 30318271)
4. Raggi P, Boulay A, Chasan-Taber S, et al,. Cardiac calcification in adult hemodialysis patients. A link between endstage renal disease and cardiovascular disease? J. Am. Coll. Cardiol. 2002; 39: 695-701. (Pubitemid 34158168)
5. Demer LL, Tintut Y,. Vascular calcification: Pathobiology of a multifaceted disease. Circulation 2008; 117: 2938-48. (Pubitemid 351787058)
6. Tyson KL, Reynolds JL, McNair R, et al,. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler. Thromb. Vasc. Biol. 2003; 23: 489-94. (Pubitemid 36337227)
7. Davies MR, Hruska A,. Pathophysiological mechanisms of vascular calcification in end stage renal disease. Kidney Int. 2001; 60: 472-9. (Pubitemid 32680895)
8. Guérin AP, London GM, Marchais SJ, et al,. Arterial stiffening and vascular calcification in end-stage renal disease. Nephrol. Dial. Transplant. 2000; 15: 1014-21. (Pubitemid 30410374)
9. Martin TJ, Moseley JM, Williams ED,. Parathyroid hormone-related protein: Hormone and cytokine. J. Endocrinol. 1997; 154: S23-S37.
10. Philbrick WM, Wysolmerski JJ, Galbraith S, et al,. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol. Rev. 1996; 76: 127-73. (Pubitemid 26048280)
11. Wu TL, Vasavada RC, Yang K, et al,. Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein. J. Biol. Chem. 1996; 271: 24371-81. (Pubitemid 26333168)
12. Broadus AE, Stewart AF,. Parathyroid hormone-related protein. Structure, processing and physiological actions. In:, Bilezikian JP, Levine MA, Marcus R, (eds). The Parathyroids. New York: Raven Press, 1994; 259-94.
13. Jüppner H, Abou-Samra AB, Freeman M, et al,. A G-protein linked receptor for parathyroid hormone and parathyroid hormone related peptide. Science 1991; 254: 1024-6. (Pubitemid 21917436)
14. Massfelder T, Helwig JJ,. Parathyroid hormone related protein in cardiovascular development and blood pressure regulation. Endocrinology 1999; 140: 1507-10. (Pubitemid 29149215)
15. Vasavada RC, Garcia-Ocana A, Massfelder T, et al,. Parathyroid hormone-related protein in the pancreatic islet and the cardiovascular system. Recent Prog. Horm. Res. 1998; 53: 305-38. (Pubitemid 128472746)
16. Wysolmerski JJ, Stewart AF,. The physiology of parathyroid hormone-related protein: An emerging role as a developmental factor. Annu. Rev. Physiol. 1998; 60: 431-60. (Pubitemid 28157882)
17. de Miguel F, Motellõn JL, Hurtado J, et al,. Comparison of two immunoradiometric assays for parathyroid hormone-related protein in the evaluation of cancer patients with and without hypercalcemia. Clin. Chim. Acta 1998; 277: 171-80. (Pubitemid 28491326)
18. Karaplis AC, Luz A, Glowacki J, et al,. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 1994; 8: 277-89. (Pubitemid 24065970)
19. Lanske B, Karaplis AC, Lee K, et al,. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 1996; 273: 663-6. (Pubitemid 26262123)
20. Orloff JJ, Ganz MB, Nathanson MH, et al,. A midregion parathyroid hormone-related peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line. Endocrinology 1996; 137: 5376-85. (Pubitemid 26423099)
21. Orloff JJ, Kats Y, Urena P, et al,. Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines. Endocrinology 1995; 136: 3016-23.
22. Valín A, García-Ocaña A, De Miguel F, et al,. Antiproliferative effect of the C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells. J. Cell. Physiol. 1997; 170: 209-15. (Pubitemid 27076222)
23. Massfelder T, Taesch N, Endlich N, et al,. Paradoxical actions of exogenous and endogenous parathyroid hormone-related protein on renal vascular smooth muscle cell proliferation: Reversion in the SHR model of genetic hypertension. FASEB J. 2001; 15: 707-18. (Pubitemid 32245989)
24. Valín A, Guillén C, Esbrit P,. C-Terminal Parathyroid Hormone-Related Protein (PTHrP) (107-139) Stimulates Intracellular Ca21 through a Receptor Different from the Type 1 PTH/PTHrP Receptor in Osteoblastic Osteosarcoma UMR 106 Cells. Endocrinology 2001; 142: 2752-9. (Pubitemid 32575509)
25. Bosch RJ, Ortega A, Izquierdo A, et al,. A transgenic mouse model for studying the role of the parathyroid hormone-related protein system in renal injury. J. Biomed. Biotechnol. 2011; 2011: 290874.
26. Martín-Ventura JL, Ortego M, Esbrit P, et al,. Possible role of parathyroid hormone-related protein as a proinflammatory cytokine in atherosclerosis. Stroke 2003; 34: 1783-9. (Pubitemid 36842646)
27. Ishikawa M, Akishita M, Kozaki K, et al,. Expression of parathyroid hormone-related protein in human and experimental atherosclerotic lesions: Functional role in arterial intimal thickening. Atherosclerosis 2000; 152: 97-105.
28. Nakayama T, Ohtsuru A, Enomoto H, et al,. Coronary atherosclerotic smooth muscle cells overexpress human parathyroid hormone-related peptides. Biochem. Biophys. Res. Commun. 1994; 200: 1028-35. (Pubitemid 24146065)
29. Chen NX, Duan D, O'Neill KD,. High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells. Nephrol. Dial. Transplant. 2006; 21: 3435-42. (Pubitemid 44817092)
30. Shioi A, Katagi M, Okuno Y, et al,. Induction of bone-type alkaline phosphatase in human vascular smooth muscle cells: Roles of tumor necrosis factor-α and oncostatin M derived from macrophages. Circ. Res. 2002; 91: 9-16. (Pubitemid 34778936)
31. London GM,. Cardiovascular disease in chronic renal failure: Pathophysiologic aspects. Semin. Dial. 2003; 16: 85-94. (Pubitemid 37356820)
32. Wang AY, Ho SS, Wang M, et al,. Cardiac valvular calcification as a marker of atherosclerosis and arterial calcification in end stage renal disease. Arch. Intern. Med. 2005; 165: 327-32. (Pubitemid 40216288)
33. Yildiz A, Memisoglu E, Oflaz H, et al,. Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertrophy in chronic haemodialysis patients. Nephrol. Dial. Transplant. 2005; 20: 760-7. (Pubitemid 40520654)
34. Jono S, McKee MD, Murry CE, et al,. Phosphate regulations of vascular smooth muscle cell calcification. Circ. Res. 2000; 87: E10-17.
35. Giachelli CM, Jono S, Shioi A, et al,. Vascular calcification and inorganic phosphate. Am. J. Kidney Dis. 2001; 38: S34-7. (Pubitemid 32927609)
36. Miguel SB, Miguel JB, Velarde LG, et al,. Prevalence and correlates of vascular disease at ultrasound examination in patients on hemodialysis. Arq. Bras. Cardiol. 2011; 96: 260-65.
37. Graciolli FG, Neves KR, dos Reis LM, et al,. Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia. Nephrol. Dial. Transplant. 2009; 24: 1416-21.
38. Coen G,. Calcimimetics, parathyroid hormone, and vascular calcification in chronic kidney disease. Kidney Int. 2008; 74: 1270-77.
39. Neves KR, Graciolli FG, dos Reis LM, et al,. Vascular calcification: Contribution of parathyroid hormone in renal failure. Kidney Int. 2007; 71: 1262-70. (Pubitemid 46884255)
40. Martin TJ, Moseley JM, Williams ED,. Parathyroid hormone-related protein: Hormone and cytokine. J. Endocrinol. 1997; 154: S23-37.
41. Martin-Ventura JL, Blanco-Colio LM, Aparicio C, et al,. LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. Atherosclerosis 2008; 198: 264-71.
42. Moe SM, Duan D, Doehle BP, et al,. Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. Kidney Int. 2003; 63: 1003-11. (Pubitemid 36315578)
43. Chen NX, Duan D, O'Neill KD, et al,. The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells. Kidney Int. 2006; 70: 1046-53. (Pubitemid 44344074)
44. Boström KI, Jumabay M, Matveyenko A, et al,. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ. Res. 2011; 108: 446-57.
45. Liu F, Zhong H, Liang JY, et al,. Effect of high glucose levels on the calcification of vascular smooth muscle cells by inducing osteoblastic differentiation and intracellular calcium deposition via BMP-2/Cbfα-1 pathway. J. Zhejiang Univ. Sci. B 2010; 11: 905-11.