Effect of high glucose levels on the calcification of vascular smooth muscle cells by inducing osteoblastic differentiation and intracellular calcium deposition via BMP-2/Cbfa-1 pathway

Journal of Zhejiang University: Science B

Volumn 11, Issue 12, 2010, Pages 905-911

  Liu, Fang ^a   Zhong, Hui ^a   Liang, Jing Yuan ^a   Fu, Ping ^a   Luo, Zhi Juan ^a   Zhou, Li ^a   Gou, Rong ^a   Huang, Jun ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Bone morphogenetic protein (BMP); Core binding factor alpha 1 (Cbfa 1); Noggin protein; Vascular smooth muscle cell

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN ANTAGONIST; CALCIUM; GLUCOSE; MESSENGER RNA; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; CARRIER PROTEIN; NOGGIN PROTEIN; TRANSCRIPTION FACTOR RUNX2;

ARTERY CALCIFICATION; ARTICLE; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; CALCINOSIS; CELL CULTURE; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; VASCULAR DISEASE;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CALCINOSIS; CALCIUM; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GLUCOSE; HUMANS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OSTEOBLASTS; RNA, MESSENGER; VASCULAR DISEASES;

EID: 79952997042     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B1000119     Document Type: Article

References (23)

1. Attisano, L., Wrana, J.L., 2002. Signal transduction by the TGF-β superfamily. Science, 296(5573):1646-1647. [doi: 10.1126/science.1071809]
2. 1 melanoma cells in the optic cup of the chick embryo. Int. J. Cancer, 122(3):526-533. [doi:10.1002/ijc.23139] (Pubitemid 350308943)
3. Canalis, E., Economides, A.N., Gazzerro, E., 2003. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr. Rev., 24(2):218-235. [doi:10.1210/er. 2002-0023] (Pubitemid 36515285)
4. Chen, N.X., O'Neill, K.D., Duan, D., Moe, S.M., 2002. Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells. Kidney Int., 62(5):1724-1731. [doi:10.1046/j.1523-1755.2002.00625.x] (Pubitemid 35286280)
5. Chen, N.X., Duan, D., O'Neill, K.D., Moe, S.M., 2006. High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells. Nephrol. Dial. Transplant., 21(12):3435-3442. [doi: 10.1093/ndt/gfl429] (Pubitemid 44817092)
6. Conley, B.A., Smith, J.D., Guerrero-Esteo, M., Bernabeu, C., Vary, C.P., 2000. Endoglin, a TGF-β receptor-associated protein, is expressed by smooth muscle cells in human atherosclerotic plaques. Atherosclerosis, 153(2):323-335. [doi:10.1016/S0021-9150(00)00422-6] (Pubitemid 32120331)
7. Dhore, C.R., Cleutjens, J.P., Lutgens, E., Cleutjens, K.B., Geusens, P.P., Kitslaar, P.J., Tordoir, J.H., Spronk, H.M., Vermeer, C., Daemen, M.J., 2001. Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol., 21(12):1998-2003. [doi:10.1161/hq1201.100229] (Pubitemid 34219753)
8. Doherty, T.M., Fitzpatrick, L.A., Inoue, D., Qiao, J.H., Fishbein, M.C., Detrano, R.C., Shah, P.K., Rajavashisth, T.B., 2004. Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr. Rev., 25(4):629-672. [doi:10.1210/er.2003-0015] (Pubitemid 39096073)
9. Lee, K.S., Kim, H.J., Li, Q.L., Chi, X.Z., Ueta, C., Komori, T., Wozney, J.M., Kim, E.G., Choi, J.Y., Ryoo, H.M., et al., 2000. Runx2 is a common target of transforming growth factor-1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblastspecific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol. Cell. Biol., 20(23):8783-8792. [doi:10.1128/MCB.20.23.8783-8792.2000] (Pubitemid 32245911)
10. Lehto, S., Niskanen, L., Suhonen, M., Rönnemaa, T., Laakso, M., 1996. Medial artery calcification a neglected harbinger of cardiovascular complications in non-insulindependent diabetes mellitus. Arterioscler. Thromb. Vasc. Biol., 16(8):978-983. (Pubitemid 26266896)
11. Moe, S.M., Chen, N.X., 2004. Pathophysiology of vascular calcification in chronic kidney disease. Circ. Res., 95(6): 560-567. [doi:10.1161/01.RES. 0000141775.67189.98] (Pubitemid 39274370)
12. Moe, S.M., Duan, D., Doehle, B.P., O'Neill, K.D., Chen, N.X., 2003. Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. Kidney Int., 63(3):1003-1011. [doi:10.1046/j.1523-1755.2003.00820.x] (Pubitemid 36315578)
13. Mori, K., Shioi, A., Jono, S., Nishizawa, Y., Morii, H., 1999. Dexamethasone enhances in vitro vascular calcification by promoting osteoblastic differentiation of vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol., 19(9):2112-2118. (Pubitemid 29422242)
14. Otto, F., Lubbert, M., Stock, M., 2003. Upstream and downstream targets of RUNX proteins. J. Cell Biochem., 89(1): 9-18. [doi:10.1002/jcb.10491] (Pubitemid 36459094)
15. Parhami, F., Basseri, B., Hwang, J., Tintut, Y., Demer, L.L., 2002. High density lipoprotein regulates calcification of vascular cells. Circ. Res., 91(7):570-576. [doi:10.1161/ 01.RES.0000036607.05037.DA]
16. Shanahan, C.M., Cary, N.R., Metcalfe, J.C., Weissberg, P.L., 1994. High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J. Clin. Invest., 93(6):2393-2402. [doi:10.1172/ JCI117246] (Pubitemid 24177151)
17. Shioi, A., Nishizawa, Y., Jono, S., Koyama, H., Hosoi, M., Morii, H., 1995. β-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol., 15(11):2003-2009.
18. Shioi, A., Katagi, M., Okuno, Y., Mori, K., Jono, S., Koyama, H., Nishizawa, Y., 2002. Induction of bone-type alkaline phosphatase in human vascular smooth muscle cells: Roles of tumor necrosis factor-a and oncostatin M derived from macrophages. Circ. Res., 91(1):9-16. [doi:10.1161/ 01.RES.0000026421.61398.F2] (Pubitemid 34778936)
19. Steitz, S.A., Speer, M.Y., Curinga, G., Yang, H.Y., Haynes, P., Aebersold, R., Schinke, T., Karsenty, G., Giachelli, C.M., 2001. Smooth muscle cell phenotypic transition associated with calcification: Upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ. Res., 89(12):1147-1154. [doi:10.1161/hh2401.101070] (Pubitemid 34627872)
20. Takayama, K., Suzuki, A., Manaka, T., Taguchi, S., Hashimoto, Y., Imai, Y., Wakitani, S., Takaoka, K., 2009. RNA interference for Noggin enhances the biological activity of bone morphogenetic proteins in vivo and in vitro. J. Bone Miner. Metab., 27(4):402-411. [doi:10.1007/s00 774-009-0054-x]
21. Tintut, Y., Patel, J., Parhami, F., 2000. Tumor necrosis factor-a promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation, 102(21):2636-2642.
22. Yuasa, S., Fukuda, K., 2008. Multiple roles for BMP signaling in cardiac development. Drug Discov. Today: Ther. Strategies, 5(4):209-214. [doi:10.1016/j.ddstr.2008.12.001]
23. Zhu, W., Kim, J., Cheng, C., Rawlins, B.A., Boachie-Adjei, O., Crystal, R.G., Hidaka, C., 2006. Noggin regulation of bone morphogenesis protein (BMP) 2/7 heterodimer activity in vitro. Bone, 39(1):61-71. [doi:10.1016/j.bone. 2005.12.018] (Pubitemid 43831779)