Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 16, 2012, Pages 4901-4914

  Shinada, Masashi ^a   Narumi, Fuminori ^a   Osada, Yuji ^a   Matsumoto, Koji ^a   Yoshida, Takayasu ^a   Higuchi, Kazuhiro ^a   Kawasaki, Tomomi ^a   Tanaka, Hiroyuki ^b   Satoh, Mitsutoshi ^b  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Enzyme inhibitor; Phenserine; Substituent effect

Indexed keywords

1,8 DIMETHYL 3A ETHYL 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YLPHENYLCARBAMATE; 1,8 DIMETHYL 3A PROPYL 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YLPHENYLCARBAMATE; 1,8 DIMETHYL 3A TERT PENTYL 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YLPHENYLCARBAMATE; 1,8 DIMETHYL 3A VINYL 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YLPHENYLCARBAMATE; 3A ALLYL 1,8 DIMETHYL 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YL(2 FLUOROPHENYL)CARBAMATE; 3A ALLYL 1,8 DIMETHYL 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YL(4 BROMOPHENYL)CARBAMATE; 3A ALLYL 1,8 DIMETHYL 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YL(4 FLUOROPHENYL)CARBAMATE; 3A ALLYL 1,8 DIMETHYL 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YL(4 ISOPROPYLPHENYL)CARBAMATE; 3A ALLYL 1,8 DIMETHYL 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YLPHENYLCARBAMATE; 3A ALLYL 1,8 DIMETHYL 2 OXO 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOL 5 YLPHENYLCARBAMATE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; PHENSERINE; PHENSERINE DERIVATIVE; PHYSOSTIGMINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; CYCLIZATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; IN VITRO STUDY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; PHYSOSTIGMINE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864490000     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.048     Document Type: Article

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