Synthesis of benzo-annulated tryptanthrins and their biological properties

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 16, 2012, Pages 4962-4967

  Liang, Jing Lu ^a   Park, So Eun ^b   Kwon, Youngjoo ^b   Jahng, Yurngdong ^a  

^a Yeungnam University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

3 Amino 2 naphthoic acid; Benzotryptanthrin; Cytotoxicity; Isatin; Isatoic anhydride; Topoisomerase I; Topoisomerase II; Tryptanthrin

Indexed keywords

BENZO[4,5]INDOLO[2,1 B]QUINAZOLINE 8,14 DIONE; BENZO[5,6]INDOLO[2,1 B]QUINAZOLINE 6,14 DIONE; BENZO[6,7]INDOLO[2,1 B]QUINAZOLINE 7,13 DIONE; BENZO[G]BENZO[4,5]INDOLO[2,1 B]QUINAZOLINE 8,16 DIONE; BENZO[G]BENZO[5,6]INDOLO[2,1 B]QUINAZOLINE 7,15 DIONE; BENZO[G]BENZO[6,7]INDOLO[2,1 B]QUINAZOLINE 7,15 DIONE; BENZO[G]INDOLO[2,1 B]QUINAZOLINE 6,14 DIONE; CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ETOPOSIDE; QUINAZOLINE DERIVATIVE; TRYPTANTHRIN; TRYPTANTHRIN DERIVATIVE; UNCLASSIFIED DRUG;

ANNULATION REACTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; OXIDATION REDUCTION POTENTIAL; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; CATTLE; DNA; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 84864485419     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.034     Document Type: Article

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