Hypoallergenic der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 2, 2012, Pages

  Chen, Kuan Wei ^a   Blatt, Katharina ^b   Thomas, Wayne R ^c   Swoboda, Ines ^b   Valent, Peter ^b   Valenta, Rudolf ^a,b   Vrtala, Susanne ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

allergen; Allergy; house dust mite allergy; recombinant hypoallergen; specific immunotherapy

Indexed keywords

CYSTEINE; HOUSE DUST ALLERGEN; RECOMBINANT DER P 1 ALLERGEN; RECOMBINANT DER P 2 ALLERGEN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; ESCHERICHIA COLI; HOUSE DUST ALLERGY; IMMUNOLOGY; IMMUNOTHERAPY; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FOLDING; PURIFICATION; RAT; T LYMPHOCYTE;

EID: 84864478694     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.05.035     Document Type: Article

References (36)

1. S.R. Durham, S.M. Walker, E.M. Varga, M.R. Jacobson, F. O'Brien, and W. Noble Long-term clinical efficacy of grass-pollen immunotherapy N Engl J Med 341 1999 468 475
2. R. Valenta The future of antigen-specific immunotherapy of allergy Nat Rev Immunol 2 2002 446 453
3. M. Larche, C.A. Akdis, and R. Valenta Immunological mechanisms of allergen-specific immunotherapy Nat Rev Immunol 6 2006 761 771
4. M. Akdis, and C.A. Akdis Therapeutic manipulation of immune tolerance in allergic disease Nat Rev Drug Discov 8 2009 645 660
5. R. Valenta, F. Ferreira, M. Focke-Tejkl, B. Linhart, V. Niederberger, and I. Swoboda From allergen genes to allergy vaccines Annu Rev Immunol 28 2010 211 241
6. A. Pecoud, L. Nicod, M. Badan, B. Agrell, S. Dreborg, and M. Kolly Effects of one-year hyposensitization in allergic rhinitis. Comparison of two house dust mite extracts Allergy 45 1990 386 392
7. D.G. Tinkelman, W.Q. Cole 3rd, and J. Tunno Immunotherapy: a one-year prospective study to evaluate risk factors of systemic reactions J Allergy Clin Immunol 95 1995 8 14
8. M.T. Mellerup, G.W. Hahn, L.K. Poulsen, and H. Malling Safety of allergen-specific immunotherapy. Relation between dosage regimen, allergen extract, disease and systemic side-effects during induction treatment Clin Exp Allergy 30 2000 1423 1429
9. G. Pittner, S. Vrtala, W.R. Thomas, M. Weghofer, M. Kundi, and F. Horak Component-resolved diagnosis of house-dust mite allergy with purified natural and recombinant mite allergens Clin Exp Allergy 34 2004 597 603
10. B.J. Hales, A.C. Martin, L.J. Pearce, I.A. Laing, C.M. Hayden, and J. Goldblatt IgE and IgG anti-house dust mite specificities in allergic disease J Allergy Clin Immunol 118 2006 361 367
11. M.D. Chapman, and T.A. Platts-Mills Purification and characterization of the major allergen from Dermatophagoides pteronyssinus-antigen P1 J Immunol 125 1980 587 592
12. C.H. Meyer, J.F. Bond, M.S. Chen, and M.T. Kasaian Comparison of the levels of the major allergens Der p I and Der p II in standardized extracts of the house dust mite, Dermatophagoides pteronyssinus Clin Exp Allergy 24 1994 1041 1048
13. A.M. Smith, and M.D. Chapman Reduction in IgE binding to allergen variants generated by site-directed mutagenesis: contribution of disulfide bonds to the antigenic structure of the major house dust mite allergen Der p 2 Mol Immunol 33 1996 399 405
14. T. Takai, T. Yokota, M. Yasue, C. Nishiyama, T. Yuuki, and A. Mori Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy Nat Biotechnol 15 1997 754 758
15. T. Takai, A. Mori, T. Yuuki, H. Okudaira, and Y. Okumura Non-anaphylactic combination of partially deleted fragments of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy Mol Immunol 36 1999 1055 1065
16. T. Takai, S. Ichikawa, H. Hatanaka, F. Inagaki, and Y. Okumura Effects of proline mutations in the major house dust mite allergen Der f 2 on IgE-binding and histamine-releasing activity Eur J Biochem 267 2000 6650 6656
17. S. Korematsu, Y. Tanaka, S. Hosoi, S. Koyanagi, T. Yokota, and B. Mikami C8/119S mutation of major mite allergen Derf-2 leads to degenerate secondary structure and molecular polymerization and induces potent and exclusive Th1 cell differentiation J Immunol 165 2000 2895 2902
18. T. Nakazawa, T. Takai, H. Hatanaka, E. Mizuuchi, T. Nagamune, and K. Okumura Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure FEBS Lett 579 2005 1988 1994
19. K. Chen, G. Fuchs, K. Sonneck, A. Gieras, I. Swoboda, and N. Douladiris Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering Mol Immunol 45 2008 2486 2498
20. D. Walgraffe, C. Matteotti, M. El Bakkoury, L. Garcia, C. Marchand, and D. Bullens A hypoallergenic variant of Der p 1 as a candidate for mite allergy vaccines J Allergy Clin Immunol 123 2009 1150 1156
21. K. Suzuki, O. Kaminuma, L. Yang, Y. Motoi, T. Takai, and S. Ichikawa Development of transgenic rice expressing mite antigen for a new concept of immunotherapy Int Arch Allergy Immunol 149 suppl 1 2009 21 24
22. J.A. Asturias, I. Ibarrola, M.C. Arilla, C. Vidal, A. Ferrer, and P.M. Gamboa Engineering of major house dust mite allergens Der p 1 and Der p 2 for allergen-specific immunotherapy Clin Exp Allergy 39 2009 1088 1098
23. A.W. Hauswirth, S. Natter, M. Ghannadan, Y. Majlesi, G.H. Schernthaner, and W.R. Sperr Recombinant allergens promote expression of CD203c on basophils in sensitized individuals J Allergy Clin Immunol 110 2002 102 109
24. R. Campana, S. Vrtala, B. Maderegger, P. Jertschin, G. Stegfellner, and I. Swoboda Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly J Allergy Clin Immunol 126 2010 1024 1031 e1-8
25. R. Valenta, K. Niespodziana, M. Focke-Tejkl, K. Marth, H. Huber, and A. Neubauer Recombinant allergens: what does the future hold? J Allergy Clin Immunol 127 2011 860 864
26. W.R. Thomas, B.J. Hales, and W.A. Smith House dust mite allergens in asthma and allergy Trends Mol Med 16 2010 321 328
27. A. Jacquet, M. Magi, H. Petry, and A. Bollen High-level expression of recombinant house dust mite allergen Der p 1 in Pichia pastoris Clin Exp Allergy 32 2002 1048 1053
28. T. Takai, R. Mineki, T. Nakazawa, M. Takaoka, H. Yasueda, and K. Murayama Maturation of the activities of recombinant mite allergens Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity FEBS Lett 531 2002 265 272
29. L. Bussieres, V. Bordas-Le Floch, I. Bulder, H. Chabre, E. Nony, and A. Lautrette Recombinant fusion proteins assembling Der p 1 and Der p 2 allergens from Dermatophagoides pteronyssinus Int Arch Allergy Immunol 153 2010 141 151
30. D. von Bubnoff, H. Matz, C. Frahnert, M.L. Rao, D. Hanau, and H. de la Salle FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses J Immunol 169 2002 1810 1816
31. G. Pittner, S. Vrtala, W.R. Thomas, M. Weghofer, M. Kundi, and F. Horak Component-resolved diagnosis of house-dust mite allergy with purified natural and recombinant mite allergens Clin Exp Allergy 34 2004 597 603
32. B.J. Hales, H. Shen, and W.R. Thomas Cytokine responses to Der p 1 and Der p 7: house dust mite allergens with different IgE-binding activities Clin Exp Allergy 30 2000 934 943
33. K. Chen, G. Fuchs, K. Sonneck, A. Gieras, I. Swoboda, and N. Douladiris Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering Mol Immunol 45 2008 2486 2498
34. K.Y. Chua, G.A. Stewart, W.R. Thomas, R.J. Simpson, R.J. Dilworth, and T.M. Plozza Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases J Exp Med 167 1988 175 182
35. S.P. Fling, and D.S. Gregerson Peptide and protein molecular weight determination by electrophoresis using a high-molarity tris buffer system without urea Anal Biochem 155 1986 83 88
36. S. Vrtala, M. Fohr, R. Campana, C. Baumgartner, P. Valent, and R. Valenta Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination Vaccine 29 2011 2140 2148