Uniformity and repeatability of normal resting myocardial blood flow in rats using [13N]-ammonia and small animal PET

Nuclear Medicine Communications

Volumn 33, Issue 9, 2012, Pages 917-925

  Lamoureux, Marc ^a   Thorn, Stephanie ^a   Dumouchel, Tyler ^a   Renaud, Jennifer M ^a   Klein, Ran ^a   Mason, Samantha ^a   Lortie, Mireille ^a   Dasilva, Jean N ^a   Beanlands, Rob S ^a   Dekemp, Robert A ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

myocardial blood flow; positron emission tomography; repeatability; small animal positron emission tomography

Indexed keywords

AMMONIA N 13;

ANALYSIS; ANIMAL EXPERIMENT; ARTICLE; COMPUTER PROGRAM; HEART MUSCLE BLOOD FLOW; MALE; NONHUMAN; PERFUSION; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; RAT;

AMMONIA; ANIMALS; BODY SIZE; CORONARY CIRCULATION; CORONARY VESSELS; MALE; NITROGEN RADIOISOTOPES; OBSERVER VARIATION; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; REST;

EID: 84864475062     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/MNM.0b013e328355d8bc     Document Type: Article

References (41)

1. Bateman TM, Heller GV, McGhie AI, Friedman JD, Case JA, Bryngelson JR, et al. Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: comparison with ECG-gated Tc-99m sestamibi SPECT. J Nucl Cardiol 2006; 13:24-33. (Pubitemid 43192726)
2. Beanlands RS, Chow BJ, Dick A, Friedrich MG, Gulenchyn KY, Kiess M, et al. CCS/CAR/CANM/CNCS/CanSCMR joint position statement on advanced noninvasive cardiac imaging using positron emission tomography, magnetic resonance imaging and multidetector computed tomographic angiography in the diagnosis and evaluation of ischemic heart disease-executive summary. Can J Cardiol 2007; 23: 107-119. (Pubitemid 46655426)
3. Demer LL, Gould KL, Goldstein RA, Kirkeeide RL, Mullani NA, Smalling RW, et al. Assessment of coronary artery disease severity by positron emission tomography. Comparison with quantitative arteriography in 193 patients. Circulation 1989; 79:825-835. (Pubitemid 19100542)
4. Yoshinaga K, Chow BJ, Williams K, Chen L, deKemp RA, Garrard L, et al. What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography? J Am Coll Cardiol 2006; 48:1029-1039. (Pubitemid 44292462)
5. DeKemp RA, Yoshinaga K, Beanlands RS. Will 3-dimensional PET-CT enable the routine quantification of myocardial blood flow? J Nucl Cardiol 2007; 14:380-397. (Pubitemid 46840302)
6. Iltis I, Kober F, Dalmasso C, Cozzone PJ, Bernard M. Noninvasive characterization of myocardial blood flow in diabetic, hypertensive, and diabetic-hypertensive rats using spin-labeling MRI. Microcirculation 2005; 12:607-614. (Pubitemid 43023804)
7. Iltis I, Kober F, Dalmasso C, Lan C, Cozzone PJ, Bernard M. In vivo assessment of myocardial blood flow in rat heart using magnetic resonance imaging: effect of anesthesia. J Magn Reson Imaging 2005; 22:242-247. (Pubitemid 41045438)
8. Iltis I, Kober F, Desrois M, Dalmasso C, Lan C, Portha B, et al. Defective myocardial blood flow and altered function of the left ventricle in type 2 diabetic rats: a noninvasive in vivo study using perfusion and cine magnetic resonance imaging. Invest Radiol 2005; 40:19-26. (Pubitemid 40029890)
9. Kober F, Iltis I, Cozzone PJ, Bernard M. Myocardial blood flow mapping in mice using high-resolution spin labeling magnetic resonance imaging: influence of ketamine/xylazine and isoflurane anesthesia. Magn Reson Med 2005; 53:601-606. (Pubitemid 40332280)
10. Waller C, Kahler E, Hiller KH, Hu K, Nahrendorf M, Voll S, et al. Myocardial perfusion and intracapillary blood volume in rats at rest and with coronary dilatation: MR imaging in vivo with use of a spin-labeling technique. Radiology 2000; 215:189-197. (Pubitemid 30190529)
11. Kudo T, Fukuchi K, Annala AJ, Chatziioannou AF, Allada V, Dahlbom M, et al. Noninvasive measurement of myocardial activity concentrations and perfusion defect sizes in rats with a new small-animal positron emission tomograph. Circulation 2002; 106:118-123. (Pubitemid 34747451)
12. 13N-ammonia and small animal PET: impact of anesthesia and pharmacologic stress agents. J Nucl Med 2004; 45:1924-1930. (Pubitemid 47618452)
13. 18F-labeled myocardial PET tracer: myocardial uptake after permanent and transient coronary occlusion in rats. J Nucl Med 2008; 49: 1715-1722.
14. 18F-labeled myocardial perfusion tracer. J Nucl Med 2008; 49:630-636. (Pubitemid 351520612)
15. 11C-acetate in rats with small-animal PET. J Nucl Med 2006; 47:477-485. (Pubitemid 46768490)
16. Czernin J, Muller P, Chan S, Brunken RC, Porenta G, Krivokapich J, et al. Influence of age and hemodynamics on myocardial blood flow and flow reserve. Circulation 1993; 88:62-69. (Pubitemid 23195433)
17. Senneff MJ, Geltman EM, Bergmann SR. Noninvasive delineation of the effects of moderate aging on myocardial perfusion. J Nucl Med 1991; 32:2037-2042.
18. Uren NG, Camici PG, Melin JA, Bol A, de Bruyne B, Radvan J, et al. Effect of aging on myocardial perfusion reserve. J Nucl Med 1995; 36: 2032-2036.
19. Chareonthaitawee P, Kaufmann PA, Rimoldi O, Camici PG. Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans. Cardiovasc Res 2001; 50:151-161. (Pubitemid 32244395)
20. 3 PET techniques. J Nucl Med 2006; 47:1193-1201. (Pubitemid 47544915)
21. Nagamachi S, Czernin J, Kim AS, Sun KT, Bottcher M, Phelps ME, et al. Reproducibility measurements of regional resting and hyperemic myocardial blood flow assessed with PET. J Nucl Med 1996; 37:1626-1631. (Pubitemid 26337164)
22. Schindler TH, Zhang XL, Prior JO, Cadenas J, Dahlbom M, Sayre J, et al. Assessment of intra-and interobserver repeatability of rest and cold pressor test-stimulated myocardial blood flow with (13)N-ammonia and PET. Eur J Nucl Med Mol Imaging 2007; 34:1178-1188. (Pubitemid 47290665)
23. Sawada S, Muzik O, Beanlands RS, Wolfe E, Hutchins GD, Schwaiger M. Interobserver and interstudy variability of myocardial blood flow and flow-reserve measurements with nitrogen 13 ammonia-labeled positron emission tomography. J Nucl Cardiol 1995; 2:413-422.
24. Jagathesan R, Kaufmann PA, Rosen SD, Rimoldi OE, Turkeimer F, Foale R, et al. Assessment of the long-term repeatability of baseline and dobutamine-induced myocardial blood flow in patients with stable coronary artery disease. J Nucl Med 2005; 46:212-219. (Pubitemid 43073426)
25. 15O-labeled water and PET. J Nucl Med 1990; 40:1848-1856.
26. Siegrist PT, Gaemperli O, Koepfli P, Schepis T, Namdar M, Valenta I, et al. Repeatability of cold pressor test-induced flow increase assessed with H(2)(15)O and PET. J Nucl Med 2006; 47:1420-1426. (Pubitemid 47544926)
27. Wyss CA, Koepfli P, Mikolajczyk K, Burger C, von Schulthess GK, Kaufmann PA. Bicycle exercise stress in PET for assessment of coronary flow reserve: repeatability and comparison with adenosine stress. J Nucl Med 2003; 44:146-154.
28. Inubushi M, Jordan MC, Roos KP, Ross RS, Chatziioannou AF, Stout DB, et al. Nitrogen-13 ammonia cardiac positron emission tomography in mice: effects of clonidine-induced changes in cardiac work on myocardial perfusion. Eur J Nucl Med Mol Imaging 2004; 31:110-116. (Pubitemid 38133548)
29. 82Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging 2007; 34:1765-1774. (Pubitemid 47599057)
30. Klein R, Renaud JM, Ziadi MC, Thorn SL, Adler A, Beanlands RS, deKemp RA. Intra-and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 PET and a highly automated analysis program. J Nucl Cardiol 2010; 17: 600-616.
31. 13N-labeled ammonia and positron emission tomography. J Nucl Cardiol 1996; 3:494-507.
32. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1:307-310. (Pubitemid 16134762)
33. Debaene B, Goldfarb G, Braillon A, Jolis P, Lebrec D. Effects of ketamine, halothane, enflurane, and isoflurane on systemic and splanchnic hemodynamics in normovolemic and hypovolemic cirrhotic rats. Anesthesiology 1990; 73:118-124. (Pubitemid 20210503)
34. Schrock GD, Krahmer RL, Ferguson JL. Coronary flow by left atrial and left ventricular microsphere injection in the rat. Am J Physiol 1990; 259: H635-H638. (Pubitemid 20259443)
35. Bartlett ML, Bacharach SL, Voipio-Pulkki LM, Dilsizian V. Artifactual inhomogeneities in myocardial PET and SPECT scans in normal subjects. J Nucl Med 1995; 36:188-195.
36. Links JM, Becker LC, Anstett F. Clinical significance of apical thinning after attenuation correction. J Nucl Cardiol 2004; 11:26-31. (Pubitemid 38219566)
37. Fahey FH, Gage HD, Buchheimer N, Smith HC, Harkness BA, Williams RC, et al. Evaluation of the quantitative capability of a high-resolution positron emission tomography scanner for small animal imaging. J Comput Assist Tomogr 2004; 28:842-848. (Pubitemid 39488566)
38. Lee JC, Karpeles LM, Downing SE. Age-related changes of cardiac performance in male rats. Am J Physiol 1972; 222:432-438.
39. Lu MH, Chao CF, Chin YH, Yu KR, Pai L. The correlation of blood pressure, age and endothelin-1 binding sites in aortic smooth muscle cells of rats. Jpn Circ J 1998; 62:532-536.
40. Safar M, Chamiot-Clerc P, Dagher G, Renaud JF. Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats. Hypertension 2001; 38:1416-1421. (Pubitemid 34033426)
41. Skov K, Fenger-Gron J, Mulvany MJ. Effects of an angiotensin-converting enzyme inhibitor, a calcium antagonist, and an endothelin receptor antagonist on renal afferent arteriolar structure. Hypertension 1996; 28:464-471. (Pubitemid 26296052)