An induced pocket for the binding of potent fusion inhibitor CL-385319 with H5N1 influenza virus Hemagglutinin

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Li, Runming ^a   Song, Deshou ^b   Zhu, Zhibo ^a   Xu, Hanhong ^b   Liu, Shuwen ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CL 385319; INFLUENZA VIRUS HEMAGGLUTININ; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CHARGE; DRUG BINDING; ELECTRICAL PARAMETERS; HUMAN; HUMAN CELL; INFLUENZA VIRUS A H5N1; LAPLACIAN CALCULATION; MATHEMATICAL PARAMETERS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR MECHANICS GENERALIZED BORN SURFACE AREA; MOLECULAR RECOGNITION; NONHUMAN; PH; PROTEIN INTERACTION; SIMULATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANTIVIRAL AGENTS; DRUG STABILITY; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; HYDROCARBONS, FLUORINATED; INFLUENZA A VIRUS, H5N1 SUBTYPE; MEMBRANE FUSION; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MUTATION; PIPERIDINES; PROTEIN BINDING; PROTEIN STABILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

ORTHOMYXOVIRIDAE;

EID: 84864467394     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041956     Document Type: Article

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