PH-dependent inhibition of native GABAA receptors by HEPES

British Journal of Pharmacology

Volumn 166, Issue 8, 2012, Pages 2402-2416

  Hugel, S ^a   Kadiri, N ^a   Rodeau, J L ^a   Gaillard, S ^a   Schlichter, R ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

bicarbonate; GABAA receptors; HEPES; hydrogen ions; pH buffers; piperazine; protons

Indexed keywords

1,4 PIPERAZINEBIS(ETHANESULFONIC ACID); 2 MORPHOLINOETHANESULFONIC ACID; 4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BICARBONATE; CHLORIDE ION; DIETHYL PYROCARBONATE; FLUMAZENIL; GLUTAMIC ACID; GLYCINE; IMIDAZOLE; PROTON; TROMETAMOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; GRANULE CELL; MEDIAN EFFECTIVE CONCENTRATION; MEMBRANE POTENTIAL; NERVE CELL; NEWBORN; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; SPINAL GANGLION;

ANIMALS; ANIMALS, NEWBORN; CEREBELLUM; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA-A RECEPTOR ANTAGONISTS; GENE EXPRESSION REGULATION; HEPES; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; NEURONS; RATS; RECEPTORS, GABA-A; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 84864465309     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01956.x     Document Type: Article

References (38)

1. th Edition. Br J PHARMACOL 164 (Suppl. 1): S1-S324.
2. Boussouf A, Lambert RC, Gaillard S, (1997). Voltage-dependent Na(+)-HCO3-cotransporter and Na+/H+ exchanger are involved in intracellular pH regulation of cultured mature rat cerebellar oligodendrocytes. Glia 19: 74-84. (Pubitemid 27050452)
3. Bowie D, Feltz P, Schlichter R, (1994). Subpopulations of neonatal rat sensory neurons express functional neurotransmitter receptors which elevate intracellular calcium. Neuroscience 58: 141-149.
4. Chen JC, Chesler M, (1992). Modulation of extracellular pH by glutamate and GABA in rat hippocampal slices. J Neurophysiol 67: 29-36.
5. Christopoulos A, Kenakin T, (2002). G protein-coupled receptor allosterism and complexing. Pharmacol Rev 54: 323-374. (Pubitemid 34575719)
6. Davenport CM, Detwiler PB, Dacey DM, (2008). Effects of pH buffering on horizontal and ganglion cell light responses in primate retina: evidence for the proton hypothesis of surround formation. J Neurosci 28: 456-464.
7. De Roo M, Rodeau JL, Schlichter R, (2003). Dehydroepiandrosterone potentiates native ionotropic ATP receptors containing the P2X2 subunit in rat sensory neurones. J Physiol 552: 59-71. (Pubitemid 37265468)
8. DeVries SH, (2001). Exocytosed protons feedback to suppress the Ca2+ current in mammalian cone photoreceptors. Neuron 32: 1107-1117.
9. Dietrich CJ, Morad M, (2010). Synaptic acidification enhances GABAA signaling. J Neurosci 30: 16044-16052.
10. Good NE, Winget GD, Winter W, Connolly TN, Izawa S, Singh RM, (1966). Hydrogen ion buffers for biological research. Biochemistry 5: 467-477.
11. Hare WA, Owen WG, (1998). Effects of bicarbonate versus HEPES buffering on measured properties of neurons in the salamander retina. Vis Neurosci 15: 263-271. (Pubitemid 28140190)
12. Huang RQ, Dillon GH, (1999). Effect of extracellular pH on GABA-activated current in rat recombinant receptors and thin hypothalamic slices. J Neurophysiol 82: 1233-1243. (Pubitemid 29439691)
13. Hugel S, Schlichter R, (2000). Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons. J Neurosci 20: 2121-2130. (Pubitemid 30230064)
14. Jacobsen EJ, Stelzer LS, TenBrink RE, Belonga KL, Carter DB, Im HK, et al,. (1999). Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. J Med Chem 42: 1123-1144. (Pubitemid 29181136)
15. Jo YH, Stoeckel ME, Freund-Mercier MJ, Schlichter R, (1998a). Oxytocin modulates glutamatergic synaptic transmission between cultured neonatal spinal cord dorsal horn neurons. J Neurosci 18: 2377-2386. (Pubitemid 28141787)
16. Jo YH, Stoeckel ME, Schlichter R, (1998b). Electrophysiological properties of cultured neonatal rat dorsal horn neurons containing GABA and met-enkephalin-like immunoreactivity. J Neurophysiol 79: 1583-1586. (Pubitemid 28125389)
17. Kaila K, Voipio J, (1987). Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Nature 330: 163-165. (Pubitemid 17158543)
18. Kaila K, Saarikoski J, Voipio J, (1990). Mechanism of action of GABA on intracellular pH and on surface pH in crayfish muscle fibres. J Physiol 427: 241-260. (Pubitemid 20256725)
19. Kaila K, Paalasmaa P, Taira T, Voipio J, (1992). pH transients due to monosynaptic activation of GABAA receptors in rat hippocampal slices. Neuroreport 3: 105-108.
20. Kaila K, Voipio J, Paalasmaa P, Pasternack M, Deisz RA, (1993). The role of bicarbonate in GABAA receptor-mediated IPSPs of rat neocortical neurones. J Physiol 464: 273-289. (Pubitemid 23169315)
21. Krishek BJ, Smart TG, (2001). Proton sensitivity of rat cerebellar granule cell GABAA receptors: dependence on neuronal development. J Physiol 530: 219-233. (Pubitemid 32998871)
22. Krishek BJ, Amato A, Connolly CN, Moss SJ, Smart TG, (1996). Proton sensitivity of the GABA(A) receptor is associated with the receptor subunit composition. J Physiol 492: 431-443.
23. Krishtal OA, Pidoplichko VI, (1980). A receptor for protons in the nerve cell membrane. Neuroscience 5: 2325-2327. (Pubitemid 11200029)
24. MacGregor DG, Chesler M, Rice ME, (2001). HEPES prevents edema in rat brain slices. Neurosci Lett 303: 141-144. (Pubitemid 32373275)
25. Makani S, Chesler M, (2007). Endogenous alkaline transients boost postsynaptic NMDA receptor responses in hippocampal CA1 pyramidal neurons. J Neurosci 27: 7438-7446. (Pubitemid 47066564)
26. McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
27. Mozrzymas JW, Zarnowska ED, Pytel M, Mercik K, (2003). Modulation of GABA(A) receptors by hydrogen ions reveals synaptic GABA transient and a crucial role of the desensitization process. J Neurosci 23: 7981-7992. (Pubitemid 37082450)
28. Palmer MJ, Hull C, Vigh J, von Gersdorff H, (2003). Synaptic cleft acidification and modulation of short-term depression by exocytosed protons in retinal bipolar cells. J Neurosci 23: 11332-11341. (Pubitemid 37549689)
29. Pasternack M, Smirnov S, Kaila K, (1996). Proton modulation of functionally distinct GABAA receptors in acutely isolated pyramidal neurons of rat hippocampus. Neuropharmacology 35: 1279-1288. (Pubitemid 27013862)
30. Robello M, Baldelli P, Cupello A, (1994). Modulation by extracellular pH of the activity of GABAA receptors on rat cerebellum granule cells. Neuroscience 61: 833-837.
31. Schmidt J, Mangold C, Deitmer J, (1996). Membrane responses evoked by organic buffers in identified leech neurones. J Exp Biol 199: 327-335.
32. Squires RF, Saederup E, (1993). Mono N-aryl ethylenediamine and piperazine derivatives are GABAA receptor blockers: implications for psychiatry. Neurochem Res 18: 787-793. (Pubitemid 23216158)
33. Sykova E, (1998). Extracellular pH and ionic shifts associated with electrical activity and pathological states in the spinal cord. In:, Kaila K, Ransom BR, (eds). Ph and Brain Function. Wiley-Liss: New York, pp. 339-358.
34. Traynelis R, (1998). pH modulation of ligand-gated ion channels. In:, Kaila K, Ransom BR, (eds). Ph and Brain Function. Wiley-Liss: New York, pp. 417-446.
35. Tunnicliff G, Smith JA, (1981). Competitive inhibition of gamma-aminobutyric acid receptor binding by N-2-hydroxyethylpiperazine-N'-2-e- ethanesulfonic acid and related buffers. J Neurochem 36: 1122-1126. (Pubitemid 11157944)
36. Voipio J, Pasternack M, Rydqvist B, Kaila K, (1991). Effect of gamma-aminobutyric acid on intracellular pH in the crayfish stretch-receptor neurone. J Exp Biol 156: 349-360.
37. Wilkins ME, Hosie AM, Smart TG, (2002). Identification of a beta subunit TM2 residue mediating proton modulation of GABA type A receptors. J Neurosci 22: 5328-5333. (Pubitemid 35386454)
38. Yamamoto D, Suzuki N, (1987). Blockage of chloride channels by HEPES buffer. Proc R Soc Lond B Biol Sci 230: 93-100. (Pubitemid 17021417)