B-Cell depletion abrogates T cell-mediated demyelination in an antibody-nondependent common marmoset experimental autoimmune encephalomyelitis model

Journal of Neuropathology and Experimental Neurology

Volumn 71, Issue 8, 2012, Pages 716-728

  Jagessar, S Anwar ^a,b   Heijmans, Nicole ^a   Bauer, Jan ^c   Blezer, Erwin L A ^d   Laman, Jon D ^b,e   Hellings, Niels ^e,f   'T Hart, Bert A ^a,b,g  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b ErasMS Center for Translational Research into MS   (Netherlands)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f HASSELT UNIVERSITY   (Belgium)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

B cell depletion; CD20; Experimental autoimmune encephalomyelitis; Marmoset; Multiple sclerosis; Neuroimmunology; T cell

Indexed keywords

CD20 ANTIBODY; CD56 ANTIGEN; FREUND ADJUVANT; GAMMA INTERFERON; HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 7; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MONOCLONAL ANTIBODY 7D8; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PLACEBO; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ARTICLE; BRAIN; CALLITHRIX; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATION; EX VIVO STUDY; EXPERIMENTAL STUDY; FEMALE; GRAY MATTER; HUMORAL IMMUNE DEFICIENCY; IMMUNIZATION; IMMUNOMODULATION; INFLAMMATION; INFLAMMATORY CELL; LYMPHOCYTE ACTIVATION; MICROGLIA; NEUROLOGIC DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SINGLE DRUG DOSE; SPINAL CORD; SURVIVAL; T CELL DEPLETION; TH17 CELL; TISSUE INJURY; WHITE MATTER;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; ANTIGENS, CD20; ANTIGENS, CD56; B-LYMPHOCYTES; BRAIN; CALLITHRIX; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYTOKINES; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNIZATION; LYMPHOCYTE DEPLETION; MYELIN PROTEINS; PHENOTYPE; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECOMBINANT PROTEINS; T-LYMPHOCYTES;

EID: 84864462920     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3182622691     Document Type: Article

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