Hypouricemic effects of novel concentrative nucleoside transporter 2 inhibitors through suppressing intestinal absorption of purine nucleosides

European Journal of Pharmacology

Volumn 690, Issue 1-3, 2012, Pages 183-191

  Hiratochi, Masahiro ^a   Tatani, Kazuya ^a   Shimizu, Kazuo ^a   Kuramochi, Yu ^a   Kikuchi, Norihiko ^a   Kamada, Noboru ^a   Itoh, Fumiaki ^a   Isaji, Masayuki ^a  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Cebus monkeys; CNT2 inhibitor; Dietary purine; Hyperuricemia

Indexed keywords

1 [3 [5 [[1 (3,4 DIHYDROXY 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL) 1H BENZIMIDAZOL 2 YLAMINO]METHYL] 2 ETHOXYPHENOXY]PROPYL]PIPERIDINE 4 CARBOXYLIC ACID AMIDE; 2 [6 AMINO 8 [[3' (3 AMINOPROPOXY)BIPHENYL 4 YLMETHYL]AMINO] 9H PURIN 9 YL] 5 HYDROXYMETHYLTETRAHYDROFURAN 3,4 DIOL; ANTIGOUT AGENT; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 2; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 2 INHIBITOR; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; INOSINE; INOSINE C 14; KGO 2142; KGO 2173; NUCLEOSIDE TRANSPORTER; PURINE NUCLEOSIDE; RNA; UNCLASSIFIED DRUG; URIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CEBUS; CONTROLLED STUDY; DRUG POTENCY; HUMAN; HUMAN CELL; HYPERURICEMIA; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; SMALL INTESTINE ABSORPTION; URIC ACID URINE LEVEL; URINARY EXCRETION;

ANIMALS; BIOLOGICAL TRANSPORT; CEBUS; CERCOPITHECUS AETHIOPS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; FURANS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; INOSINE; INTESTINAL ABSORPTION; MALE; MEMBRANE TRANSPORT PROTEINS; PURINE NUCLEOSIDES; RATS; RATS, SPRAGUE-DAWLEY; RENAL TUBULAR TRANSPORT, INBORN ERRORS; RNA, FUNGAL; URIC ACID; URINARY CALCULI;

EID: 84864462904     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.06.015     Document Type: Article

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