Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 16, 2012, Pages 4985-4994

  Cherian, Philip T ^a   Yao, Jiangwei ^a   Leonardi, Roberta ^a   Maddox, Marcus M ^a   Luna, Vicki A ^b   Rock, Charles O ^a   Lee, Richard E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Antibacterial; Membrane; Phospholipid; PlsY

Indexed keywords

3 (SULFAMOYLOXY)BENZOFURAN 6 YL PALMITOYLSULFAMATE; 3 CHLOROPHENYL PALMITOYLSULFAMATE; 3,4 DICHLOROPHENYL PALMITOYLSULFAMATE; 4 (2 AMINOETHYL)PHENYL PALMITOYLSULFAMATE; 4 [2 (TERT BUTOXYCARBONYLAMINO)ETHYL]PHENYL PALMITOYLSULFAMATE; 4 CHLOROPHENYL PALMITOYLSULFAMATE; 4 METHOXYPHENYL PALMITOYLSULFAMATE; 4 METHOXYPHENYL TETRADECANOYLSULFAMATE; 4 METHOXYPHENYL UNDEC 10 ENOYLSULFAMATE; 4 TOLYL PALMITOYLSULFAMATE; 4' NITROBIPHENYL 4 YL PALMITOYLSULFAMATE; ACYL CARRIER PROTEIN; ACYL SULFAMATE DERIVATIVE; ANTIINFECTIVE AGENT; BENZO[D][1,3]DIOXOL 5 YL PALMITOYLSULFAMATE; CYCLOHEXYL PALMITOYLSULFAMATE; CYCLOPENTYL PALMITOYLSULFAMATE; ETHYL 4 (N PALMITOYLSULFAMOYLOXY)BENZOATE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; LONG CHAIN FATTY ACID; METHYL 2 [4 (N PALMITOYLSULFAMOYLOXY)PHENYL]ACETATE; METHYL PALMITOYLSULFAMATE; PHENYL PALMITOYLSULFAMATE; PHOSPHOLIPID; PIPERIDIN 4 YL PALMITOYLSULFAMATE; QUINOLIN 6 YL PALMITOYLSULFAMATE; TERT BUTYL 4 (N PALMITOYLSULFAMOYLOXY)PIPERIDINE 1 CARBOXYLATE; TETRAHYDRO 2H PYRAN 4 YL PALMITOYLSULFAMATE; TETRAHYDROFURAN 3 YL PALMITOYLSULFAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITOR COMPLEX; ENZYME SUBSTRATE COMPLEX; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHOSPHOLIPID SYNTHESIS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACILLUS ANTHRACIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PHAGES; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 84864459442     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.029     Document Type: Article

References (17)

1. L.L. Silver Clin. Microbiol. Rev. 24 2011 71
2. L.B. Rice Curr. Opin. Microbiol. 12 2009 476
3. Y.J. Lu, Y.M. Zhang, K.D. Grimes, J. Qi, R.E. Lee, and C.O. Rock Mol. Cell 23 2006 765
4. J.G. Hurdle, A.J. O'Neill, I. Chopra, and R.E. Lee Nat. Rev. Microbiol. 9 2011 62
5. Y.J. Lu, F. Zhang, K.D. Grimes, R.E. Lee, and C.O. Rock J. Biol. Chem. 282 2007 11339
6. K.D. Grimes, Y.J. Lu, Y.M. Zhang, V.A. Luna, J.G. Hurdle, E.I. Carson, J. Qi, S. Kudrimoti, C.O. Rock, and R.E. Lee ChemMedChem 2008 1936 3
7. L. Paoletti, Y.J. Lu, G.E. Schujman, D. de Mendoza, and C.O. Rock J. Bacteriol. 189 2007 5816
8. P.H. Ray, T.T. Lillich, and D.C. White J. Bacteriol. 112 1972 413
9. P.H. Ray, and D.C. White J. Bacteriol. 109 1972 668
10. J.B. Parsons, M.W. Frank, C. Subramanian, P. Saenkham, and C.O. Rock Proc. Natl. Acad. Sci. U S A 108 2011 15378
11. C.L. Cooper, S. Jackowski, and C.O. Rock J. Bacteriol. 169 1987 605
12. C.O. Rock, and S. Jackowski J. Biol. Chem. 257 1982 10759
13. C.O. Rock, J.E. Cronan Jr., and I.M. Armitage J. Biol. Chem. 256 1981 2669
14. S. Jackowski, and C.O. Rock J. Biol. Chem. 258 1983 15186
15. V.A. Luna, D.S. King, J. Gulledge, A.C. Cannons, P.T. Amuso, and J. Cattani J. Antimicrob. Chemother. 60 2007 555
16. Amsterdam, D. Lorian, V., Ed.; Lippincott Williams & Wilkins: Baltimore MD, 1996, pp. 52.
17. E.G. Bligh, and W.J. Dyer Can. J. Physiol. Pharmacol. 37 1959 911