Study on hepatotoxicity of aqueous extracts of Polygonum multiflorum in rats after 28-day oral administration-analysis on correlation of cholestasis

Zhongguo Zhongyao Zazhi

Volumn 37, Issue 10, 2012, Pages 1445-1450

  Wang, Tao ^a   Wang, Jiaying ^a   Jiang, Zhenzhou ^a   Zhou, Zhixing ^b   Li, Yanyan ^a   Zhang, Liang ^c   Zhang, Luyong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Aqueous extracts of Polygonum multiflorum; Cholestasis; Hepatotoxicity; Oral administration; Rat

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; POLYGONATUM EXTRACT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE COMPOSITION; BILE DUCT DISEASE; BODY WEIGHT; CHOLESTASIS; CONTROLLED STUDY; DISEASE SEVERITY; EPITHELIUM CELL; FLOW RATE; HISTOPATHOLOGY; LIVER CELL; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; POLYGONUM; RAT; SERUM;

ADMINISTRATION, ORAL; ANIMALS; BILE; CHOLESTASIS; FEMALE; LIVER; MALE; PLANT EXTRACTS; POLYGONUM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84864447705     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20121021     Document Type: Article

References (12)

1. Kostrubsky S E, Strom S C, Kaigutkar A S, et aL Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone[J]. Toxicol Sci, 2006,90(2):451.
2. Crocenzi F A, Sánchez Pozzi E J, Pellegrino J M, et al Beneficial effects of Silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets[J]. Hepatology, 2001, 34(2):329.
3. Zhou Zhixing, Wang Tao, Jiang Zhenzhou, et aL Beneficial effects of colchicine on 17α-ethynylestradiol-induced cholestasis in rats[J]. Arzneimittelforsch, 2011, 61(3):173.