Nanotherapeutics: Emerging competent technology in neuroAIDS and CNS drug delivery

Nanomedicine

Volumn 7, Issue 7, 2012, Pages 941-944

  Saxena, Shailendra K ^a   Tiwari, Sneham ^a   Nair, Madhavan P N ^b  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

blood brain barrier; dendrimers; gold nanoparticles; liposomes; nanocarriers; silver nanoparticles

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CENTRAL NERVOUS SYSTEM AGENTS; DENDRIMER; GOLD NANOPARTICLE; LANTHANIDE; LIPOSOME; SILVER NANOPARTICLE; SOLID LIPID NANOPARTICLE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; BLOOD BRAIN BARRIER; DRUG DELIVERY SYSTEM; NANOMEDICINE; NANOMOTOR; NANOTHERAPEUTICS; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW; VIRUS ACTIVATION;

AIDS DEMENTIA COMPLEX; ANIMALS; ANTI-HIV AGENTS; BLOOD-BRAIN BARRIER; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HIV; HUMANS; NANOPARTICLES;

EID: 84864432705     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.12.63     Document Type: Review

References (20)

1. Service RF. Nanotechnology. Nanoparticle trojan horses gallop from the lab into the clinic. Science 330(6002), 314-315 (2010).
2. Wagner V, Dullaart A, Bock AK, Zweck A. The emerging nanomedicine landscape. Nat. Biotechnol. 24(10), 1211-1217 (2006). (Pubitemid 44564760)
3. Choi HS, Ipe BI, Misra P, Lee JH, Bawendi MG, Frangioni JV. Tissue-and organ-selective biodistribution of NIR fuorescent quantum dots. Nano Lett. 9(6), 2354-2359 (2009).
4. Di Gianvincenzo P, Marradi M, Martínez-Avila OM, Bedoya LM, Alcamí J, Penadés S. Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents. Bioorg. Med. Chem. Lett. 20(9), 2718-2721 (2010).
5. Kwasa J, Cettomai D, Lwanya E et al. Lessons learned developing a diagnostic tool for HIV-associated dementia feasible to implement in resource-limited settings: pilot testing in Kenya. PLoS One 7(3), e32898 (2012).
6. Nowacek AS, McMillan J, Miller R, Anderson A, Rabinow B, Gendelman HE. Nanoformulated antiretroviral drug combinations extend drug release and antiretroviral responses in HIV-1-infected macrophages: implications for neuroAIDS therapeutics. J. Neuroimmune Pharmacol. 5(4), 592-601 (2010).
7. Silva GA. Nanomedicine: shorting neurons with nanotubes. Nat. Nanotechnol. 4(2), 82-83 (2009).
8. Bressani RF, Nowacek AS, Singh S et al. Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage. Nanotoxicology 5(4), 592-605 (2011).
9. Nowacek AS, Miller RL, McMillan J et al. NanoART synthesis, characterization, uptake, release and toxicology for human monocyte-macrophage drug delivery Nanomedicine (Lond.) 4(8), 903-917 (2009).
10. Minchin R. Nanomedicine: sizing up targets with nanoparticles. Nat. Nanotechnol. 1, 12-13 (2008).
11. Dou H, Grotepas CB, McMillan JM et al. Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS. J. Immunol. 183(1), 661-669 (2009).
12. Saiyed ZM, Gandhi NH, Nair MP. AZT 5'-triphosphate nanoformulation suppresses human immunodefciency virus type 1 replication in peripheral blood mononuclear cells. J. Neurovirol. 15(4), 343-347 (2009).
13. Cressey D. Tiny traits cause big headaches. Nature 467(7313), 264-265 (2010).
14. Nowacek A, Gendelman HE. NanoART, neuroAIDS and CNS drug delivery Nanomedicine (Lond.) 4(5), 557-574 (2009).
15. Kovochich M, Marsden MD, Zack JA. Activation of latent HIV using drug-loaded nanoparticles. PLoS One 6(4), e18270 (2011).
16. Gandapu U, Chaitanya RK, Kishore G, Reddy RC, Kondapi AK. Curcumin-loaded apotransferrin nanoparticles provide effcient cellular uptake and effectively inhibit HIV-1 replication in vitro. PLoS One 6(8), e23388 (2011).
17. Mallipeddi R, Rohan LC. Progress in antiretroviral drug delivery using nanotechnology. Int. J. Nanomedicine 5, 533-547 (2010).
18. Myyryläinen T, Talha SM, Swaminathan S et al. Simultaneous detection of human immunodefciency virus 1 and hepatitis B virus infections using a dual-label time-resolved fuorometric assay. J. Nanobiotechnology 8, 27 (2010).
19. Langer R. Drug delivery and targeting. Nature 392, 5-10 (1998). (Pubitemid 28215187)
20. Tyssen D, Henderson SA, Johnson A et al. Structure activity relationship of dendrimer microbicides with dual action antiviral activity. PLoS One 5(8), e12309 (2010).