Lessons learned developing a diagnostic tool for HIV-associated dementia feasible to implement in resource-limited settings: Pilot testing in Kenya

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Kwasa, Judith ^a   Cettomai, Deanna ^a,b   Lwanya, Edwin ^a   Osiemo, Dennis ^a   Oyaro, Patrick ^a   Birbeck, Gretchen L ^c   Price, Richard W ^b   Bukusi, Elizabeth A ^a   Cohen, Craig R ^b   Meyer, Ana Claire L ^a,b  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

ADULT; AGE DISTRIBUTION; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; FEASIBILITY STUDY; FEMALE; HEALTH CARE PERSONNEL; HIGH SCHOOL; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; KAPPA STATISTICS; KENYA; MALE; MEDICAL EXPERT; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; OUTPATIENT CARE; PATIENT SELECTION; PILOT STUDY; RELIABILITY; SENSITIVITY AND SPECIFICITY; SEX RATIO; HEALTH CARE PLANNING; MIDDLE AGED;

ADULT; AIDS DEMENTIA COMPLEX; FEMALE; HEALTH PERSONNEL; HEALTH RESOURCES; HUMANS; KENYA; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PILOT PROJECTS; YOUNG ADULT;

EID: 84857893638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032898     Document Type: Article

References (52)

1. World Health Organization (2007) WHO Case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. Geneva.
2. Meyer A, (2009) Prevalence of HIV associated encephalopathy using clinical database: Unpublished data.
3. Kvalsund M, Haworth A, Murman D, Velie E, Birbeck G, (2009) Short Report: Closing Gaps in Antiretroviral Therapy Access: Human Immunodeficiency Virus-Associated Dementia Screening Instruments for Non-Physician Healthcare Workers. Am J Trop Med Hyg 80: 1054-1059.
4. Maj M, Satz P, Janssen R, Zaudig M, Starace F, et al. (1994) WHO Neuropsychiatric AIDS study, cross-sectional phase II. Neuropsychological and neurological findings. Arch Gen Psychiatry 51: 51-61.
5. Njamnshi AK, Djientcheu Vde P, Fonsah JY, Yepnjio FN, Njamnshi DM, et al. (2008) The International HIV Dementia Scale is a useful screening tool for HIV-associated dementia/cognitive impairment in HIV-infected adults in Yaounde-Cameroon. J Acquir Immune Defic Syndr 49: 393-397.
6. Howlett WP, Nkya WM, Mmuni KA, Missalek WR, (1989) Neurological disorders in AIDS and HIV disease in the northern zone of Tanzania. AIDS 3: 289-296.
7. Perriens JH, Mussa M, Luabeya MK, Kayembe K, Kapita B, et al. (1992) Neurological complications of HIV-1-seropositive internal medicine inpatients in Kinshasa, Zaire. J Acquir Immune Defic Syndr 5: 333-340.
8. Clifford DB, Mitike MT, Mekonnen Y, Zhang J, Zenebe G, et al. (2007) Neurological evaluation of untreated human immunodeficiency virus infected adults in Ethiopia. J Neurovirol 13: 67-72.
9. Sacktor NC, Wong M, Nakasujja N, Skolasky RL, Selnes OA, et al. (2005) The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS 19: 1367-1374.
10. Wong MH, Robertson K, Nakasujja N, Skolasky R, Musisi S, et al. (2007) Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology 68: 350-355.
11. Portegies P, de Gans J, Lange JM, Derix MM, Speelman H, et al. (1989) Declining incidence of AIDS dementia complex after introduction of zidovudine treatment. BMJ 299: 819-821.
12. Sacktor N, Lyles RH, Skolasky R, Kleeberger C, Selnes OA, et al. (2001) HIV-associated neurologic disease incidence changes:: Multicenter AIDS Cohort Study, 1990-1998. Neurology 56: 257-260.
13. d'Arminio Monforte A, Cinque P, Mocroft A, Goebel F-D, Antunes F, et al. (2004) Changing incidence of central nervous system diseases in the EuroSIDA cohort. Ann Neurol 55: 320-328.
14. Bhaskaran K, Mussini C, Antinori A, Walker AS, Dorrucci M, et al. (2008) Changes in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretroviral therapy. Ann Neurol 63: 213-221.
15. Sacktor NC, Lyles RH, Skolasky RL, Anderson DE, McArthur JC, et al. (1999) Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS). Neurology 52: 1640-1647.
16. Sacktor N, Nakasujja N, Skolasky R, Robertson K, Wong M, et al. (2006) Antiretroviral therapy improves cognitive impairment in HIV+ individuals in sub-Saharan Africa. Neurology 67: 311-314.
17. Sacktor NC, Skolasky RL, Lyles RH, Esposito D, Seines OA, et al. (2000) Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors. J Neurovirol 6: 84-88.
18. World Health Organization, World Federation of Neurology (2004) Atlas: Country Resources for Neurologic Disorders. Geneva pp. 1-62.
19. World Health Organization (2006) The world health report: working together for health. http://www.who.int/whr/2006/whr06_en.pdf, Accessed 2010 September 1.
20. Jowi J, (2007) Provision of Care to People with Epilepsy in Kenya. East African Medical Journal 84: 97-99.
21. Singh D, Joska J, Goodkin K, Lopez E, Myer L, et al. (2010) Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans. BMC Research Notes 3: 28.
22. Robertson KR, Nakasujja N, Wong M, Musisi S, Katabira E, et al. (2007) Pattern of neuropsychological performance among HIV positive patients in Uganda. BMC Neurol 7: 8.
23. World Health Organization (2008) Task shifting: rational redistribution of tasks among health workforce teams: global recommendations and guidelines: http://www.who.int/healthsystems/TTR-TaskShifting.pdf, Accessed: 2010 September 1.
24. Antinori A, Arendt G, Becker J, Brew B, Byrd D, et al. (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69: 1789-1799.
25. Chelune G, Heaton R, Lehman R, (1986) Neuropsychological and personality correlates of patients' complaints of disability. In: Goldstein G, editors. Advances in clinical neuropsychology New York Plenium Press pp. 95-126.
26. Folstein M, Folstein S, McHugh P, (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res Nov 12 (3): 189-198.
27. Katz S, Ford A, Moskowitz R, Jackson B, Jaffe M, (1963) Studies of Illness in the Aged. The Index of ADL: A standardized measure of biological and psychosocial function. JAMA 185: 914-919.
28. Lawton M, Brody E, (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9: 179-186.
29. RAND Health Appendix A Core Survey Instrument: The Medical Outcomes Study 116 item core set of measures of functioning and well-being. http://www.rand.org/content/dam/rand/www/external/health/surveys_tools/mos/mos_core_survey.pdf. Accessed: 2008 May 25.
30. Schag C, Heinrich R, Ganz P, (1984) Karnofsky Performance Status Revisited: Reliability, Validity and Guidelines. Journal of Clinical Oncology 2: 187-193.
31. Wechsler D, (1997) WAIS-III: Administration and Scoring Manual: The Psychological Corporation.
32. Lezak MD, Howieson DB, Loring DW, Hannay HJ, JS F, eds. (2004) Neuropsychological Assessment. 4th ed New York Oxford University Press pp. 422-429.
33. Maj M, Janssen R, Starace F, Zaudig M, Satz P, et al. (1994) WHO Neuropsychiatric AIDS study, cross-sectional phase I. Study design and psychiatric findings. Arch Gen Psychiatry 51: 39-49.
34. Benedict RHB, eds. (1997) Brief Visual memory Test-Revised. 4th ed Florida Psychological Assessment Resources, Inc.
35. Lafayette I, (2003) Grooved Pegboard User's Manual Lafayette, IN Lafayette Instrument Company, Inc.
36. PAR (1992) Finger Tapper User's Guide Florida Psychological Assessment Resources, Inc.
37. Robertson KR, Parsons TD, Sidtis JJ, Hanlon Inman T, Robertson WT, et al. (2006) Timed Gait test: normative data for the assessment of the AIDS dementia complex. J Clin Exp Neuropsychol 28: 1053-1064.
38. Gladsjo JA, Schuman CC, Evans JD, Peavy GM, Miller SW, et al. (1999) Norms for letter and category fluency: demographic corrections for age, education, and ethnicity. Assessment 6: 147-178.
39. Monsch AU, Bondi MW, Butters N, Salmon DP, Katzman R, et al. (1992) Comparisons of verbal fluency tasks in the detection of dementia of the Alzheimer type. Arch Neurol 49: 1253-1258.
40. Strauss E, Sherman E, Spreen O, (2006) A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary New York Oxford University Press Inc.
41. Monahan P, Shacham E, Reece M, Kroenke K, On'gor W, et al. (2008) Validity/Reliability of PHQ-9 and PHQ-2 Depression Scales Among Adults Living with HIV/AIDS in Western Kenya. Journal of General Internal Medicine 24: 189-197.
42. Birbeck GL, Chomba E, Kvalsund M, Bradbury R, Mang'ombe C, et al. (2009) Antiretroviral adherence in rural Zambia: the first year of treatment availability. Am J Trop Med Hyg 80: 669-674.
43. Jarvis Joseph N, Lawn Stephen D, Vogt M, Bangani N, Wood R, et al. (2009) Screening for Cryptococcal Antigenemia in Patients Accessing an Antiretroviral Treatment Program in South Africa. Clin Infect Dis 48: 856-862.
44. Liechty CA, Solberg P, Were W, Ekwaru JP, Ransom RL, et al. (2007) Asymptomatic serum cryptococcal antigenemia and early mortality during antiretroviral therapy in rural Uganda. Trop Med Int Health 12: 929-935.
45. Sacktor N, (2002) The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. J Neurovirol 8: 115-121.
46. Saykin A, Janssen R, Sprehn G, Kaplan J, Spira T, et al. (1991) Longitudinal evaluation of neuropsychological function in homosexual men with HIV infection: 18 month follow up. J Neuropsychiatry Clin Neurosci 3: 286-298.
47. McArthur JC, Haughey N, Gartner S, Conant K, Pardo C, et al. (2003) Human immunodeficiency virus-associated dementia: an evolving disease. J Neurovirol 9: 205-221.
48. Heaton RK, Grant I, Butters N, White DA, Kirson D, et al. (1995) The HNRC 500-neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center. J Int Neuropsychol Soc 1: 231-251.
49. Tozzi V, Balestra P, Lorenzini P, Bellagamba R, Galgani S, et al. (2005) Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002: results from an urban observational cohort. J Neurovirol 11: 265-273.
50. Dunbar N, Brew B, (1997) Neuropsychological Dysfunction in HIV Infection: A Review. J NeuroAIDS 1: 73-102.
51. Power C, Selnes O, Grim J, McArthur J, (1995) HIV Dementia Scale: a rapid screening test. Journal of Acquired Immunodeficiency Syndrome and Human Retrovirology 8: 273-278.
52. Castaneda A, Suvisaari J, Marttunen M, Perala J, Saarni S, et al. (2008) Cognitive functioning in a population-based sample of young adults with a history of non-psychotic unipolar depressive disorders without psychiatric comorbidity. J Affect Disord 110: 36-45.