Correlation of brain biomarker neuron specific enolase (NSE) with degree of disability and neurological worsening in cerebrovascular stroke

Indian Journal of Clinical Biochemistry

Volumn 27, Issue 2, 2012, Pages 186-190

  Bharosay, Anuradha ^a   Bharosay, Vivek Vikram ^a   Varma, Meena ^a   Saxena, Kiran ^b   Sodani, Ajoy ^a   Saxena, Ravi ^b  

^a SRI AUROBINDO INSTITUTE OF MEDICAL SCIENCES   (India)

^b Chirayu Medical College   (India)

Author keywords

Degree of disability; Ischemic stroke; National Institute of Health Stroke Scale (NIHSS); Neurological worsening; Neuron specific enolase (NSE)

Indexed keywords

BIOCHEMICAL MARKER; NEURON SPECIFIC ENOLASE;

ADULT; AGED; ANALYZER; ARTICLE; BLOOD SAMPLING; BRAIN DAMAGE; BRAIN ISCHEMIA; CONTROLLED STUDY; DISABILITY; DISABILITY SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; PREDICTIVE VALUE;

EID: 84864430246     PISSN: 09701915     EISSN: 09740422     Source Type: Journal    
DOI: 10.1007/s12291-011-0172-9     Document Type: Article

References (18)

1. Marangos PJ. Neuron specific enolase: a clinically useful marker of neurons and neuroendocrine cells. Annu Rev Neurosci. 1987;10:269-95.
2. Barone FC, Clark RK, Price WJ, White RF, Feuerstein GZ, Storer BL, Ohlstein EH. Neuron-specific enolase increases in cerebral and systemic circulation following focal ischemia. Brain Res. 1993;623:77-82.
3. Butterworth RJ, Wassif WS, Sherwood RA, Gerges A, Poyser KH, Garthwaite J, Peters TJ, Bath PMW. Serum neuron-specific enolase, carnosinase, and their ratio in acute stroke. Stroke. 1996;27:2064-8.
4. Cunningham RT, Watt M, Winder J, McKinstry S, Lawson JT, Johnston CF, Hawkins SA, Buchanan KD. Serum neurone-specific enolase as an indicator of stroke volume. Eur J Clin Invest. 1996;26:298-303.
5. Hårdemark HG, Ericsson N, Kotwica Z, Rundströ G, Mendel-Hartvig I, Olsson Y, Påhlman S, Persson L. S-100 protein and neuron-specific enolase in CSF after experimental traumatic or focal ischemic brain damage. J Neurosurg. 1989;71:727-31.
6. Hatfield RH, McKernan RM. CSF neuron-specific enolase as a quantitative marker of neuronal damage in a rat model. Brain Res. 1992;577:249-52.
7. Horn M, Seger F, Schlote W. Neuron-specific enolase in gerbil brain and serum after transient cerebral ischemia. Stroke. 1995; 26:290-7.
8. Casmiro M, Maitan S, De Pasquale F. Cerebrospinal fluid and serum neuron-specific enolase concentrations in a normal population. Eur J Neurol. 2005;12(5):369-74.
9. Kwan J. Hand P Early neurological deterioration in acute stroke: clinical characteristics and impact on outcome. QJM. 2006;99: 625-33.
10. Fassbender K, Schmidt R, Schreiner A, et al. Leakage of brain-originated proteins in peripheral blood: temporal profile and diagnostic value in early ischemic stroke. J Neurol Sci. 1997; 148(1):101-5.
11. Anand N, Stead LG. Neuron-specific enolase as a marker for acute ischemic stroke: a systematic review. Cerebrovasc Dis. 2005;20(4):213-9.
12. Stevens H, Jakobs C, de Jager AE, Cunningham RT, Korf J. Neurone-specific enolase and N-acetyl-aspartate as potential peripheral markers of ischaemic stroke. Eur J Clin Invest. 1999; 29:6-11.
13. Hill MD, Jackowski G, Bayer N, Lawrence M, Jaeschke R. Biochemical markers in acute ischemic stroke. CMAJ. 2000;162: 1139-40.
14. Schaarschmidt H, Prange HW, Reiber H. Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebro-vascular disease. Stroke. 1994;25:558-65.
15. Wunderlich MT, Ebert AD, Kratz T, Goertler M, Jost S, Herrmann M. Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage. Stroke. 1999;30:1190-5.
16. Ferrarese C, Mascarucci P, Zoia C, Cavarretta R, Frigo M, Begni B. Increased cytokine release from peripheral blood cells after acute stroke. J Cereb Blood Flow Metab. 1999;19:1004-9.
17. Smith CJ, Emsley HCA, Gavin CM, et al. Peak plasma inter-leukin-6 and other peripheral markers of inflammation in the first week of ischemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurol. 2004;4:2.
18. Missler U, Wiesmann M, Friedrich C, Kaps M. S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke. 1997;28:1956-60.